Copenhagen University Hospital

Which penile cancer patients with metastasis in a sentinel node may be spared inguinal lymph node dissection without compromising oncological safety? Development of a low-risk selection model

Abstract Purpose To develop and internally validate a low-risk selection model to guide omission of completion inguinal lymph node dissection (ILND) after a positive dynamic sentinel node biopsy (DSNB) and to identify predictors of an inguinal basin harboring additional inguinal...

Extending single-cell proteomics from HeLa to small primary human immune cells

Abstract Single-cell proteomics (SCP) holds the promise of decoding cellular heterogeneity at the functional level, yet achieving deep and reproducible proteome coverage from individual cells has remained a formidable challenge. Here, we establish a high-sensitivity, label-free S...

Distinct body mass index trajectories throughout childhood in girls with early puberty

Abstract Background Early pubertal development in girls has been associated with increased adiposity in childhood. However, longitudinal body mass index (BMI) trajectories preceding the diagnosis of precocious puberty (PP) or premature adrenarche (PA) are less well described. We...

Incidentally detected vertebral fractures and risk of myeloma: a prospective cohort study of 9059 CT-scanned Danish general population individuals

Vertebral fractures are frequently detected incidentally on computed tomography (CT) scans performed for other indications in individuals with no symptoms of a fracture [ 1 ]. In myeloma, >45% of patients have vertebral fractures at the time of myeloma diagnosis [ 2 ]. However, t...

Immune regulation includes an effector arm: therapeutic implications of phase III IDO/PD-L1 vaccination in melanoma

In a recent phase III study in Annals of Oncology , first-line IDO/PD-L1 peptide vaccination plus pembrolizumab in advanced melanoma provided clinical support for a microenvironment-targeting vaccine strategy. The broader significance of these data is that they support immune mod...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

No group-level changes in corticospinal excitability following low-intensity theta-burst ultrasound stimulation of the primary motor hand area

Abstract Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique offering high spatial precision and depth penetrance. Theta burst TUS (tbTUS), featuring a temporal theta burst stimulation pattern, has been reported to facilitat...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

Impaired Lung Function in Liver Transplant Recipients Compared With the General Population: A Nationwide Matched Cohort Study

Background. Liver transplant recipients have elevated risk of acute pulmonary infections, but the burden of chronic pulmonary diseases in liver transplant recipients remains largely unknown. We aimed to determine the association between living with a transplanted liver and both s...

Awake or Asleep Subthalamic Deep Brain Stimulation for Parkinson's Disease: Further Research Is Needed

BACKGROUND AND OBJECTIVES: This systematic review aims to evaluate the differences in clinical efficacy and quality of life between asleep and awake subthalamic nucleus deep brain stimulation (STN-DBS) procedures in patients with Parkinson's disease. METHODS: A comprehensive sear...

Transverse Myelitis and Guillain–Barré Syndrome in Pediatric Lymphoid Malignancies: An International Retrospective Study

Central and peripheral neurotoxicity after methotrexate is a rare but challenging complication of therapy for pediatric lymphoid malignancies. In this Ponte-di-Legno Toxicity Working Group and international Berlin-Frankfurt-Münster Group study, we describe nine children and adole...

Pattern of Failure in Nasopharyngeal Carcinoma After Radiotherapy in a Low‐Incidence Population: A DAHANCA Study

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon in many populations. Most existing clinical evidence comes from endemic areas, where Epstein-Barr virus (EBV)-associated subtypes predominate. We analyzed patterns of failure in a population-based cohort from Denmark, a low-i...

Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome

ABSTRACT Background Glutamate is the main excitatory neurotransmitter in the brain, and extracellular levels of glutamate and glycerol (a breakdown product of cell damage) increase after severe acute brain injury. Previous studies report that increased intracerebral glutamate—mea...

Assessment of foot perfusion before and after revascularization using quantitative ICG near-infrared fluorescence imaging in patients with and without diabetes mellitus

Diabetes Mellitus(DM) complicates peripheral artery disease (PAD) by increasing neuropathy, ischemia, and amputation risk. Perfusion differences between PAD patients with and without diabetes may support more personalized revascularization strategies than current WIfI-based predi...

Copenhagen longitudinal study on quality of life in a young adult population with gliomas

Abstract Background Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall surviva...

Association between p-tau181 in cerebrospinal fluid and shunt response in patients with normal-pressure hydrocephalus

Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is a treatable condition, but predicting shunt response remains challenging. Cerebrospinal fluid (CSF) biomarkers, including phosphorylated tau (p-tau181), have been suggested as potential predictors, although ex...

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

Growth and Fibrosis in Children With Biliary Atresia: A Retrospective Cohort Study

ABSTRACT Aim To determine growth patterns and catch up potential in children with biliary atresia, in relation to liver disease severity and liver transplantation. Methods This retrospective cohort study was conducted at Copenhagen University Hospital between 1 January 2006 and 3...

Severe Odontogenic Infections With Endodontic Origin: A Retrospective Cohort Study

AIM: Endodontic infections can spread, leading to life-threatening systemic infections. However, the available literature is limited concerning factors associated with a higher risk. This study aimed to characterize patients hospitalized with a severe endodontic infection spread...

Paired comparison of extrinsic feedback effects on motor learning and functional recovery after stroke: a secondary analysis of randomized controlled trials

Introduction Extrinsic feedback (EF) provides external signals during motor practice to enhance knowledge of performance or results. While EF can improve outcomes after stroke, its relative effects on motor learning versus functional recovery remain unclear.Objective To directly...