Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Molecular mechanism of calcium inhibition in viral channelrhodopsins

Abstract Viral channelrhodopsins (VCR1s) are giant-virus-encoded light-gated channels permeable to monovalent and divalent cations, including Na + and Ca 2+ ions, and inhibited by millimolar Ca 2+ concentrations. Here, we combine X-ray crystallography, time-resolved UV-vis spectr...

TMD factorization in diffractive heavy quark production in photon-nucleus collisions

A bstract Using the Colour Glass Condensate effective theory, we study the diffractive production of a massive quark-antiquark pair accompanied by a gluon in coherent photon-nucleus collisions at high energy. This partonic configuration provides the leading twist contribution to...

InN Nanowires on Si⟨111⟩ and Si⟨100⟩ for Monolithic Short-Wave Infrared (SWIR) Photodetectors

Abstract InN nanowires were grown on Si⟨111⟩ and Si⟨100⟩ substrates by plasma-assisted molecular beam epitaxy using a thin AlN buffer layer at temperatures compatible with the thermal budget limitation imposed by back-end-of-line processing. Reflection high-energy electron diffra...

210Pbex in lacustrine sediments: A half-century global synthesis (1977-2024)

Unsupported 210 Pb ( 210 Pb ex ) is a naturally occurring radionuclide widely used to establish sediment chronologies spanning the past ∼150 years, thereby providing high-resolution temporal frameworks for palaeolimnological reconstructions. Since the late 1970s, numerous hypothe...

TurboID ‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

Summary Iron Regulated Transporter1 (IRT1) is the major root iron transporter responsible for broad‐spectrum metal absorption in Arabidopsis thaliana root epidermal cells. Non‐iron metal substrates of IRT1 were recently shown to regulate IRT1 cell surface levels by endocytosis an...

Sympatric European white oaks species display contrasting epigenetic response to soil water availability

Abstract In the context of climate change plants have to cope with adverse conditions, among which water scarcity is a major threat for their survival. They have developed diverse regulatory processes to face drought that may differ depending on their ecological niche. The two sy...

Perinatal exposure to nano-polystyrene: deleterious imprinting on inflammatory bowel diseases

The extent of production and use of plastics leads to release of nanoplastics (NPL) into the environment, where they undergo weathering that could alter their toxicological properties. NPL enter the human food chain via contaminated food, and food packaging, and within the body t...

Strongly coupled stimulated Brillouin amplification with flying focus

Damage to compression gratings poses a fundamental limit to chirped pulse amplification in high-power laser systems. Plasma-based compressors using strongly coupled stimulated Brillouin scattering (scSBS) offer a damage-free alternative, but their effectiveness has been hindered...

Convergence Analysis of a High-Order Multiscale Finite Element Method (MsFEM) for Stokes Flows in Heterogeneous Media

Abstract. An enriched nonconforming Multiscale Finite Element Method (MsFEM) to solve viscous incompressible flow problems in genuine heterogeneous or porous media was proposed in [Q. Feng, G. Allaire, and P. Omnes, Multiscale Model. Simul., 20 (2022), pp. 462–492]. The main feat...

Chiral-Induced Spin Selectivity as a Driving Force in Enantiorecognition: A Generator-and-Reader Perspective

Abstract Enantiorecognition is conventionally rationalized through stereochemical models, such as lock-and-key, induced-fit, and three-point interaction schemes, in which a chiral selector discriminates between enantiomers through geometry and noncovalent interactions. Neverthele...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

Probing electron transport and thermodynamic properties in expanded warm dense matter

The expanded warm dense matter regime, an intermediate state between condensed matter and high-energy-density plasma at low density, remains poorly constrained experimentally, particularly regarding transport properties across the metal-to-nonmetal transition. Here, we explore ex...

Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study

Abstract Background Prematurity is associated with a high risk of abnormal neurodevelopment, inflicting life-long neurocognitive consequences with major public health importance. This calls for early biomarkers of functional brain development to serve as indicators of the effect...

Dry snow initialization and densification over the Greenland and Antarctic ice sheets in the ORCHIDEE land surface model

Abstract. Accurate modeling of the snowpack over ice sheets is essential for quantifying their surface mass balance contribution and their resulting impact on sea level rise. The snowpack evolution is largely governed by surface climate but also by internal processes such as dens...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Current and Future Directions for Responsible Quantum Technologies: A ResQT Community Perspective

Abstract Quantum technologies (QT) are advancing rapidly, promising advancements across a wide spectrum of applications but also raising significant ethical, societal, and geopolitical impacts, including dual-use capabilities, varying levels of access, and impending quantum divid...

Paleoenvironmental and paleoclimatic reconstruction in the Western Mediterranean during the Late Early Pleistocene

Abstract. The major climate change recorded during the Early-Middle Pleistocene Transition (1.4–0.4 Ma) is characterized by an increase in the length of climatic cycles from 41 to 100 ka. During this period, the Mediterranean climate underwent aridification associated with a drop...

DNA methylation either antagonizes or promotes Polycomb recruitment at transposable elements in Arabidopsis

Abstract Transposable elements (TEs) are usually silenced by DNA methylation and H3K9me2, but in the absence of DNA methylation they can instead acquire the Polycomb-associated mark H3K27me3. Here, we initially set out to test whether DNA methylation and H3K27me3 compete during T...

Increased maximum carbon release offsets half of the growth trend in annual land carbon sink

The terrestrial carbon sink has strengthened in recent decades through enhanced maximum CO2 uptake (MCU) and a longer carbon uptake period (CUP), whereas maximum CO2 release (MCR) remains less quantified. Using atmospheric inversion estimates and 16 terrestrial biosphere models,...

A first extraction of gluon TMDs from Higgs data at the LHC

Abstract We present the first extraction of the unpolarised gluon transverse-momentum-dependent (TMD) parton distribution from Higgs-boson production data at the LHC within the framework of TMD factorisation. The analysis is based on the currently available set of ATLAS and CMS m...