Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Optimizing Portal Venous Phase Acquisition Quality of Contrast-Enhanced CT in Oncology

Background: Portal venous phase (PVP) contrast-enhanced CT is a cornerstone for response assessment in early-phase oncology trials, yet contrast-enhancement phase timing remains insufficiently monitored across sites. We assessed PVP timing using a validated artificial intelligenc...

Integrating Drug Physicochemistry and Hfq-Dependent Regulation of Ciprofloxacin Accumulation in Escherichia coli

Ciprofloxacin (CIP), an amphoteric fluoroquinolone, undergoes pH-dependent changes in protonation state that influence membrane permeability and intracellular accumulation. Here, we investigated how drug physicochemistry and bacterial regulatory pathways jointly determine CIP acc...

The OpenSat4Weather dataset: Ku-band satellite link data for precipitation monitoring

Abstract. The TV-SAT signals received by the ground antennas of Satellite Microwave Links (SMLs) can be opportunistically used for identifying and quantifying precipitation. Hence, SMLs can serve as low-cost rainfall sensors complementary to conventional instruments. However, a s...

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Superinfection exclusion strategy of siphophage T5: analysis of the FhuA:Llp complex

ABSTRACT Superinfection exclusion is a widespread viral mechanism that protects the infected cell from overinfection by other identical or closely related viruses. Shortly after infection by bacteriophage T5, the bacterium Escherichia coli produces Llp, encoded by the newly injec...

Resolving the LiFePO4 Battery State beyond Voltage-Based Diagnostics Using Surface-Scan MRI

Reliable assessment of state of charge (SoC) and state of health (SoH) in commercial batteries remains a major challenge because their closed architecture obscures the underlying electrochemical, structural, and thermal processes, while existing diagnostic methods often provide o...

Structure-activity relationship and membrane-targeting mechanisms of shikimate-related metabolites against Gram-positive and Gram-negative bacteria

AIMS: The rise of antibiotic-resistant bacteria has intensified the search for novel antimicrobials. In this context, shikimic acid is a versatile scaffold widely used as a precursor to bioactive compounds and drugs. This study screened the antimicrobial activity and underlying m...

Minimizer Density Revisited: Models and Multiminimizers

High-throughput sequence analysis commonly relies on k-mers and sampling schemes to improve scalability and data locality. Among these, local schemes are widely used and are typically evaluated by their density, the expected fraction of selected positions. Minimizers are the most...

Domain‐Wall Circulation Gating and Pinning via Compositional Engineering of Cylindrical Nanowires

ABSTRACT Spintronic devices based on cylindrical magnetic nanowires have been proposed as a route toward three–dimensional (3D) information storage and processing by harnessing the controlled motion of domain walls (DWs). In this geometry, the Bloch‐point wall (BPW) is the charac...

Novel geometrical test of cosmological expansion from photometric data

In tomographic cosmic-shear observations, the Bernardeau, Nishimichi, Taruya (BNT) transform allows us to build weak lensing transformed maps for which the contribution from low-redshift lenses is nulled. As this transformation depends specifically on the expansion rate of the Un...

Revisiting quantum effects on dislocation glide in bcc metals from DFT calculations and machine-learning potentials

Quantum zero-point effects have been long proposed to explain a well-known discrepancy between the low-temperature flow stresses of body-centered cubic metals and corresponding atomistic models of plastic flow. Previous investigations on quantum effects relied on empirical intera...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

Geometry-enforced topological chiral fermions in amorphous chiral metals

Since the prediction and observation of topological Weyl semimetals (chiral TSMs), there have been enormous efforts to characterize further condensed matter realizations of chiral fermions. These efforts were dramatically accelerated by the subsequent discovery of a profound link...

Improved estimation of net ecosystem CO 2 exchange over North America using LSTM-based flux upscaling (2001–2021)

Accurate estimation of regional-scale terrestrial carbon budgets is of great importance but remains challenging. With particular advantages, the Long Short-Term Memory (LSTM) network method shows potential for improving regional carbon budget upscaling estimations. Here, using LS...

Super Bloom: Fast and Precise Filter for Streaming k -Mer Queries

Approximate membership query structures are used throughout sequence bioinformatics, from read screening and metagenomic classification to assembly, indexing, and error correction. Among them, Bloom filters remain the default choice. They are not the most efficient structures in...

Collective adsorption of pheromones at the water–air interface

Abstract Understanding the phase behaviour of pheromones and other messaging molecules remains a significant and largely unexplored challenge, even though it plays a central role in chemical communication. Here, we present all-atom molecular dynamics simulations to investigate th...

Photonic integrated recurrent spectrum slicer enabling low complexity direct detection over 200 GBaud dispersive links

Abstract The rising demand for data-intensive workloads in the network is driving the development of scalable and energy-efficient optical communication infrastructure. Intensity modulation with direct detection (IM/DD) remains the preferred choice for cost-sensitive systems but...

Thickness-Dependent Spintronic Terahertz Emission in Molecular Beam Epitaxy-Grown PtTe2: From Semiconductor to Type-II Dirac Semimetal

Abstract Spintronic THz emitters are the most practical broadband sources, but their performance is constrained by the spin Hall conductivity of the conversion layer. We show that PtTe2, a type II Dirac semimetal, overcomes this limitation through thickness-driven electronic phas...

Evidence-Tiered Venomics of the BotG50 Toxic Fraction from Buthus tunetanus Reveals a Diversified Neurotoxin Repertoire

Scorpion venoms represent complex pharmacological arsenals whose complete molecular inventory remains incompletely defined, particularly for North African buthid species of high medical relevance. Buthus tunetanus is among the most clinically significant scorpion species across t...

Consistent estimates of carbonyl sulfide and methane stratospheric lifetimes retrieved from AirCore profiles at different latitudes

Stratospheric loss is a major sink for both carbonyl sulfide (COS) and methane (CH 4 ), but their stratospheric lifetimes and sinks remain poorly constrained because high-resolution observations of their vertical distributions in the lower stratosphere are sparse. Here, we estima...