Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Rapid estimation of structural brain disconnection from binary lesion masks using DeepDisco

Abstract Mapping how focal brain lesions disrupt structural connectivity is key to understanding cognition, behavior, and neurological outcomes. However, traditional diffusion tractography pipelines are computationally intensive, require specialized data and expertise, and remain...

Consistent estimates of carbonyl sulfide and methane stratospheric lifetimes retrieved from AirCore profiles at different latitudes

Stratospheric loss is a major sink for both carbonyl sulfide (COS) and methane (CH 4 ), but their stratospheric lifetimes and sinks remain poorly constrained because high-resolution observations of their vertical distributions in the lower stratosphere are sparse. Here, we estima...

Targeting the Complement C1 Proteases Using Camelid-Derived Single Domain Antibodies: Production, Characterization and Possible Application for Tissue/Fluid Analysis

Background. The complement C1r and C1s proteases initiate the classical complement pathway within the C1 complex, but emerging evidence points to additional roles in tissues, including cell-intrinsic functions linked to cancer and connective tissue disorders. Few tools are availa...

A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile

Abstract Cyclic diguanosine monophosphate (c-di-GMP) is a second messenger that coordinates lifestyle transitions, virulence, and developmental processes in bacteria. In Clostridioides difficile , elevated c-di-GMP levels inhibit sporulation, but the underlying mechanism remained...

Leveraging Symbolic Artificial Intelligence and Fuzzy Logic for Materials Science: A Review of Methods, Challenges, and Applications to Scarce and Imperfect Experimental Data

This article explores the transformative potential of symbolic artificial intelligence (AI) in the field of materials science, particularly in leveraging experimental data. While state‐of‐the‐art methods like neural networks and statistical models face challenges with limited and...

Direct numerical simulation of turbulent natural convection in a heat generating fluid within a shallow horizontal enclosure

Core catchers are a significant safety feature of Generation-IV nuclear reactors for the safe dissipation of decay heat and maintaining the integrity of the reactor containment in the event of a severe accident. Direct numerical simulation is used to simulate turbulent natural co...

MicroRNA 517a-3p suppresses α-synuclein fibril accumulation in human glioblastoma cells

Abstract Background Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-...

Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes

Abstract Chiral 1,3-dioxygenated motifs are key scaffolds in bioactive natural products, yet their synthesis via intermolecular oxa-Michael addition to α,β-unsaturated aldehydes remains challenging notably due to the high reversibility of the oxygenated nucleophile addition. This...

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

AADT: Abstract Abstract Data Types

Proving properties of programs that manipulate compound data structures requires both disjunctive reasoning (e.g., a pointer may target different arrays) and relational reasoning. Existing abstract interpreters struggle to combine both: non-relational designs support modular comp...

Emotional Responses (Intensity/Valence) Fulfill RDoC Criteria but Remain Excluded From Diagnostic Classifications of Mood Disorders

OBJECTIVES: Categorical classifications of depression, such as DSM-5 and ICD, are limited by high clinical heterogeneity, arbitrary diagnostic thresholds, and weak links to underlying pathophysiology. In line with the Research Domain Criteria (RDoC) framework, this article propos...

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system emp...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Wall-crossing phenomenon for the liquid bin model

We introduce the liquid bin model as a continuous-time deterministic dynamics, arising as the hydrodynamic limit of a discrete-time stochastic interacting particle system called the infinite bin model. For the liquid bin model, we prove the existence and uniqueness of a stationar...

Indoor UAV for Nuclear Investigation: Experimental Qualification and Field Feedback

ABSTRACT Indoor Unmanned Aerial Vehicles (UAVs) have recently gained interest for inspection and investigation tasks in hazardous environments. In the nuclear field, indoor UAVs offer promising capabilities to reduce workers' exposure to ionizing radiation while accessing confine...

NetSyn: prokaryotic genomic context exploration of protein families

Background . The growing availability of large prokaryotic genomic datasets presents an opportunity to discover new metabolic pathways and enzymatic reactions useful for industrial or synthetic biological applications. Efforts to identify new enzyme functions in this vast number...

Diffusion and gettering mechanisms of W and Fe in 300 mm silicon substrates

Metallic contamination is a major reliability issue in CMOS image sensor processing, where recombination-active impurities can increase dark current and pixel defects. In this work, the behavior of tungsten and iron is studied in several 300 mm silicon-based stacks under the same...

Experimental investigation of surface inclination effects on ablation of a solid impacted by a hot liquid jet

In sodium-cooled fast reactors (SFRs), the potential consequences of a severe accident with core meltdown are now considered during the reactor design phase. Such events lead to the formation of a corium , a radioactive mixture of molten nuclear fuel and structural materials. Two...

Redefining Last Glacial Maximum environmental conditions in northeastern Brazil: pollen-based evidence of open and moist-adapted vegetation cover

Limited continuous continental records and complex climatic interactions hinder a comprehensive understanding of paleoclimatic and paleoenvironmental conditions during the Last Glacial Maximum (LGM) in the tropics. Adjacent to the currently semi-arid northeastern Brazil (NEB), a...

More is not always better: Dissociative photoionization limits the EUV absorbing photoacid generator pentafluorophenyl triflate in photolithography

Pentafluorophenyl triflate has been explored as a highly absorbing neutral photoacid generator (PAG) candidate for next-generation chemically amplified resists used in extreme ultraviolet (EUV) lithography. Although increased fluorination enhances EUV absorption, this study demon...