China Pharmaceutical University

Phage as a prospective arsenal against superbugs

The escalating crisis of antimicrobial resistance (AMR) necessitates the urgent development of alternatives to traditional antibiotics. Bacteriophage (phage) therapy, which utilizes viruses that specifically infect and lyse bacteria, has re-emerged as a promising therapeutic stra...

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases

Dysregulated activation of the stimulator of interferon genes (STING) pathway underlies various inflammatory and autoimmune pathologies. Since STING oligomerization is fundamental to its biological function, targeted modulation of this polymerization process presents a promising...

Third-party governance and artificial intelligence for diabetes management in primary health care, China.

Problem: Fragmented primary health care in China fails to tackle the growing burden of noncommunicable diseases. Despite substantial investment, fewer than half of patients with diabetes achieve glycaemic control. Approach: Tianjin's 2020-2023 reform established a public-private...

Spatiotemporally Controlled Double Self‐Emulsifying Microneedles for Co‐Delivery of Eugenol and Puerarin to Promote Healing and Tissue Regeneration of Infected Diabetic Wounds

Chronic infected diabetic foot ulcers (DFUs) pose a persistent challenge due to biofilm-shielded infections, excessive inflammation, and impaired tissue repair. Here, we present a first-in-class microneedle system that redefines eugenol (EUG), a natural compound, as a multifuncti...