China Pharmaceutical University

Go-Game-Driven Introduction to Monte Carlo Simulation of Langmuir Adsorption

Abstract The ancient Chinese strategy game Go is an ideal analogical anchor for teaching the Langmuir monolayer adsorption model. Well-crafted gameplay that integrates Go sets with dice rolls can simulate stochastic molecular collisions and visualize complex computational logic....

Integrated Pharmacokinetics, Pharmacodynamics, and Pharmacometabolomics to Elucidate Guizhi Fuling Capsule’s Homeostatic Mechanism Against Acute Dysmenorrhea

Background/Objectives: Guizhi Fuling Capsule (GZFL), a Traditional Chinese Medicine (TCM) formula, is widely used for primary dysmenorrhea and other blood-stasis gynecological disorders. This study aimed to characterize its material basis, elucidate its multi-component, multi-tar...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Fibrin-Binding Peptide-Functionalized H2O2-Responsive Retinoic Acid Micelles for Attenuating Thrombosis-Associated Oxidative and Inflammatory Responses

Background/Objectives: Thrombotic cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Current antithrombotic therapies are limited by insufficient thrombus targeting. This study aimed to develop a fibrin-binding peptide-functionalized, hydrogen pero...

Exchange Characteristics in Interprofessional Collaboration Between Clinical Pharmacists and Physicians: A National Survey

Objectives: Exchange characteristics describe and evaluate the state of collaboration and the collaborative counterpart from the perspectives of both parties. They reflect the interaction tendencies between collaborators and are important factors influencing the effectiveness of...

QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study

The concomitant use of ceftriaxone and proton pump inhibitors (PPIs) is common in hospital practice. However, it is unclear whether individual PPIs differ in their effects on QT interval prolongation, ventricular arrhythmia, or cardiac arrest, collectively termed as QVC events. W...

The Allergen Detective: An Undergraduate GC-FID/MS Laboratory Activity for Investigation of Volatile Ingredients in Essential Oil

Abstract This laboratory experiment introduces a natural volatile product analysis experiment for undergraduate students majoring in chemistry and pharmacy, helping students to gain a deeper understanding of chromatographic methods in natural-product analysis. It involves the use...

Pharmacological inhibition of Alistipes putredinis-derived indole-3-acetic acid by baicalin suppresses stress-driven breast cancer metastasis

Breast cancer patients often experience chronic stress disorders and gut dysbiosis. Baicalin has been demonstrated to have antitumor, antibacterial and microbiota regulatory functions and can be used for treating breast cancer and preventing metastasis; however, how baicalin regu...

Rapid Identification of Multiple Types of Adulterated Ophiocordyceps sinensis by SEM ‐ EDS Based on Micromorphology and Elemental Analysis

As a rare and precious traditional Chinese medicine (TCM), Ophiocordyceps sinensis (O. sinensis) is plagued by various adulterants in the market due to factors such as resource scarcity, which seriously affects medication safety and clinical efficacy. Existing identification meth...

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

ABSTRACT Toosendanin (TSN) is a highly potent natural anticancer compound derived from the fruit of Fructus Meliae Toosendan. In this study, TSN inhibited melanoma cell proliferation and cell‐cycle progression, induced apoptosis, and suppressed metastasis in both in vitro and in...

Evolving an Aptameric Nose for Synthetic Cannabinoids Through Modular Reprogramming of Specificity

ABSTRACT Discerning subtle structural differences among highly similar small molecules remains a major challenge for synthetic receptors. Natural olfactory systems solve this problem using cross‐reactive receptor families that combine a conserved docking core with hypervariable s...

Cumulative spatial assessment of observed wildlife-vehicle collisions based on indicator species thresholds

Global road network expansion has exacerbated wildlife-vehicle collisions. However, traditional risk assessments predominantly assume a linear relationship between landscape features and observed collision quantities, overlooking the non-linear threshold characteristics of ecolog...

Harnessing the E3 Ligase KLHL12 for Tumor‐Selective Protein Degradation

ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are currently constrained by a reliance on ubiquitously expressed E3 ligases, which compromises tumor selectivity and raises toxicity risks. Here, we identified KLHL12 as a potentially tumor‐selective E3 ligase and reported the de...

Comparison and Selection of Network Meta‐Analysis Models for Fitting and Extrapolating Cancer Survival Data

ABSTRACT Aim To assess network meta‐analysis (NMA) model biases under different proportional hazards (PHs) scenarios, compare fitting and extrapolation performance for hazard ratios (HRs) using cancer survival data, identify metrics guiding model selection, and compare extrapolat...

m6A epitranscriptomic regulation in asthma: mechanisms and therapeutic prospects

Asthma is a heterogeneous airway disease in which chronic inflammation, epithelial barrier injury, immune-cell imbalance and airway remodeling interact to shape variable clinical phenotypes. N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, has...

Aminosulfine‐Based Donor Platform for Controlled Release of Sulfenic Acid (HSOH)

ABSTRACT Reactive sulfur species derived from hydrogen sulfide are central regulators of redox signaling; however, sulfenic acid (HSOH) has remained largely inaccessible owing to the absence of chemically defined donor systems. Here we report a mechanistically delineated strategy...

Aminosulfine‐Based Donor Platform for Controlled Release of Sulfenic Acid (HSOH)

ABSTRACT Reactive sulfur species derived from hydrogen sulfide are central regulators of redox signaling; however, sulfenic acid (HSOH) has remained largely inaccessible owing to the absence of chemically defined donor systems. Here we report a mechanistically delineated strategy...

Hostile microenvironment-driven oxygenator hydrogel with spatiotemporally feedback regulated hif-1α for accelerating diabetic wound healing

Diabetic wounds remain notoriously intractable due to a hostile microenvironment characterized by hyperglycemia, hypoxia, and oxidative stress. However, existing therapies often lack the ability to autonomously and sustainably remodel this pathological niche. Herein, a smart nano...

The SIMDA framework maps PIP2-binding sites regulating the KCNQ1 channel

Voltage-gated potassium channel KCNQ1 (Kv7.1) underpins cardiac repolarization, epithelial ion transport, and inner ear function. Its versatility arises from interactions with KCNE proteins, calmodulin (CaM), and the lipid phosphatidylinositol 4,5-bisphosphate (PIP2), yet the mol...

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Transfer RNA-derived small RNAs (tsRNAs) are a novel class of small non-coding RNAs abundant in the bloodstream of cancer patients and involved in various physiological and pathological processes. However, the regulatory mechanisms and clinical significance of tsRNAs in colorecta...