China Medical University

Preparation of a new fixed-combination carteolol-netarsudil ophthalmic solution via one-pot pH-adjusting solubilization strategy for glaucoma treatment

Currently, the commercial fixed-combination of two agents is facing several clinical challenges, including suboptimal intraocular pressure (IOP) reduction, which requires multiple daily administrations, compromised bioavailability due to rapid tear film clearance and nasolacrimal...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies

The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Weakly supervised artificial intelligence for multi-cancer detection of lymph node metastasis on whole slide images

Abstract The accurate identification of lymph node metastasis is critical for cancer diagnosis/treatment but remains time-consuming and error-prone for pathologists. We develop MambaMIL+HiLA-MIL, a multiple instance learning model combining Vision Mamba with high-low attention se...

Constructing multifunctional biointerfaces: Polyoxometalate-based hydrogels—design, functionalization, and translational challenges

Abstract Polyoxometalate (POM)-based hydrogels are emerging organic-inorganic hybrid materials that combine the biological functions of POMs with the biocompatibility and tunable mechanical properties of polymer networks. This review summarizes recent advances in their compositio...

2-Ethylhexyl diphenyl phosphate exposure is associated with poorer overall survival in advanced high-grade serous ovarian cancer: Integrated epidemiological and experimental evidence implicating the ITGB1–FAK–AKT axis

Background Organophosphate esters (OPEs) are globally used flame retardants and plasticizers with widespread human exposure. Whether OPE exposure affects survival in advanced high-grade serous ovarian cancer (HGSOC) and the underlying mechanisms remains unclear. We aimed to ident...

Proximal point method with Bregman distance for nonconvex quasi-equilibrium problems

We introduce a Bregman proximal point method for solving pseudomonotone quasi-equilibrium problems. The algorithm is formulated using Bregman distances generated by Legendre functions and allows the bifunction to be nonconvex. Unlike existing Euclidean proximal approaches, our me...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Fibroblast-driven matrix remodeling shapes immune exclusion in lung cancer

The lung tumor microenvironment (TME) is shaped by reciprocal interactions among cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), immune cells, endothelial cells, and tumor cells. Available evidence supports an integrated sequence in which tumor-derived factors,...

Efficacy of percutaneous transhepatic gallbladder drainage for acute cholecystitis during pregnancy: a retrospective cohort study

Contrary to the current guidelines, pregnant patients with moderate to severe acute cholecystitis (AC) often avoid surgery due to concerns of the potential maternal and fetal risks. Percutaneous transhepatic gallbladder drainage (PTGBD) can serve as an alternative to emergent cho...

A review of pretreatment and analytical techniques for amphetamine type stimulants in complex samples

Amphetamine-type stimulants (ATSs) are among the most widely abused drugs globally, posing serious threats to public health through addiction, physical and psychological harm, and associated social problems such as increased crime rates. Effective clinical management of ATSs over...

A novel prognostic score based on carbohydrate antigen 125, alpha-fetoprotein and carcinoembryonic antigen for Predicting postoperative prognosis in endometrial cancer: Results from a retrospective cohort study

Endometrial cancer (EC) is a common gynecological malignancy with increasing incidence. While several serum biomarkers have been studied for EC, their combined prognostic value remains unclear. This study aimed to evaluate the prognostic significance of preoperative serum CA125,...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

MORC2-Mediated Glutamine Metabolic Remodeling Regulates Tumor-Associated Macrophage Function and Immunotherapeutic Responses in NSCLC

Non-small cell lung cancer (NSCLC) frequently exhibits primary or acquired resistance to PD-1/PD-L1 blockade, partly because of the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) are a major immune-cell population in NSCLC and contribute to tumor pr...

Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis

Abstract Background Immunosenescence, characterized by telomere shortening, senescence-associated T-cell subsets, and chronic inflammation, is a hallmark of biological aging. Whether these aging-related immune biomarkers can be modulated through short-term intervention and whethe...

Traumatic brain injury in African urban centers: The role of road traffic accidents, outcomes, and health-system factors: a systematic review

Abstract Background Traumatic brain injury (TBI) is a major cause of death and disability in low- and middle-income countries, particularly in rapidly urbanizing regions of Sub-Saharan Africa. Road traffic accidents (RTAs), especially motorcycle-related crashes, represent a leadi...

Developing nonlinear time-varying weighted combined prediction framework for infectious diseases: validation with respiratory infectious diseases and sexually transmitted infections

Traditional combined prediction models often face limitations in their ability to capture complex nonlinear relationships and weighting. To address these challenges, we propose a nonlinear time-varying weighted combined prediction framework that integrates deep learning algorithm...

Decoding how macronutrients influence depressive symptoms: Combined insights from regression, nonlinear modeling, and machine learning: a cross-sectional study using NHANES data

Dietary management is an essential component of comprehensive depression care;however, studies simultaneously evaluating multiple macronutrients and their associations with depressive symptoms are limited. Data from National Health and Nutrition Examination Survey 2005 to 2023 we...

A machine learning-derived dietary pattern for aging

Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis a...