China Medical University

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Benchmarking of pathology foundation models for assessing HER2 amplification and CEP17 polysomy in breast cancer

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) amplification and Chromosome 17 (CEP17) copy number is critical for breast cancer treatment, yet diagnostically equivocal (IHC 2+) cases remain a clinical bottleneck. This study systematically benchma...

Emerging and Re‐Emerging Viral Pathogens in Oncolytic Virotherapy: A Comprehensive Review

Oncolytic virotherapy has recently emerged as a promising immuno-oncological strategy, utilising the natural cytolytic potentials of viral pathogens to selectively target and destroy malignant cells. Although various engineered viruses, such as adenoviruses, vaccinia virus, and h...

Pretreatment creatinine-to-cystatin C ratio as a prognostic marker in solid cancers: a systematic review and meta-analysis with trial sequential analysis and reconstructed time-to-event validation

The creatinine-to-cystatin C ratio (CCR) has been proposed as an indirect laboratory marker related to muscle mass and systemic health status. This systematic review and meta-analysis evaluated the association between pretreatment CCR and survival outcomes in patients with solid...

Intrinsic capacity decline and multilevel intervention needs of disabled older adults in nursing homes: a qualitative study based on the social-ecological systems theory

Intrinsic capacity (IC) is a central pillar of healthy ageing. Diminished IC is closely associated with poorer health outcomes and a greater degree of care dependence among disabled older adults. This study used the social-ecological framework to examine lived experiences and int...

Efficacy and evidence certainty of traditional Chinese exercises for musculoskeletal disorders: an umbrella review of meta-analyses

Objectives To comprehensively evaluate the efficacy and exercise prescription parameters of traditional Chinese exercises (TCEs) on health outcomes in patients with musculoskeletal disorders (MSDs) and rigorously assess the certainty of the evidence. Design Umbrella review. Data...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Preparation of a new fixed-combination carteolol-netarsudil ophthalmic solution via one-pot pH-adjusting solubilization strategy for glaucoma treatment

Currently, the commercial fixed-combination of two agents is facing several clinical challenges, including suboptimal intraocular pressure (IOP) reduction, which requires multiple daily administrations, compromised bioavailability due to rapid tear film clearance and nasolacrimal...

Association of prenatal exposure to PM2.5 and its chemical constituents with early childhood obesity: A population-based study

A growing body of evidence links gestational fine particulate matter (PM 2.5 ) exposure to elevated childhood obesity risk, yet research on the combined impacts and respective contributions of different PM 2.5 chemical constituents remains limited. This large population-based pro...

Weakly supervised artificial intelligence for multi-cancer detection of lymph node metastasis on whole slide images

Abstract The accurate identification of lymph node metastasis is critical for cancer diagnosis/treatment but remains time-consuming and error-prone for pathologists. We develop MambaMIL+HiLA-MIL, a multiple instance learning model combining Vision Mamba with high-low attention se...

Constructing multifunctional biointerfaces: Polyoxometalate-based hydrogels—design, functionalization, and translational challenges

Abstract Polyoxometalate (POM)-based hydrogels are emerging organic-inorganic hybrid materials that combine the biological functions of POMs with the biocompatibility and tunable mechanical properties of polymer networks. This review summarizes recent advances in their compositio...

Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies

The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Proximal point method with Bregman distance for nonconvex quasi-equilibrium problems

We introduce a Bregman proximal point method for solving pseudomonotone quasi-equilibrium problems. The algorithm is formulated using Bregman distances generated by Legendre functions and allows the bifunction to be nonconvex. Unlike existing Euclidean proximal approaches, our me...

2-Ethylhexyl diphenyl phosphate exposure is associated with poorer overall survival in advanced high-grade serous ovarian cancer: Integrated epidemiological and experimental evidence implicating the ITGB1–FAK–AKT axis

Background Organophosphate esters (OPEs) are globally used flame retardants and plasticizers with widespread human exposure. Whether OPE exposure affects survival in advanced high-grade serous ovarian cancer (HGSOC) and the underlying mechanisms remains unclear. We aimed to ident...

Fibroblast-driven matrix remodeling shapes immune exclusion in lung cancer

The lung tumor microenvironment (TME) is shaped by reciprocal interactions among cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), immune cells, endothelial cells, and tumor cells. Available evidence supports an integrated sequence in which tumor-derived factors,...

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and anti...

Efficacy of percutaneous transhepatic gallbladder drainage for acute cholecystitis during pregnancy: a retrospective cohort study

Contrary to the current guidelines, pregnant patients with moderate to severe acute cholecystitis (AC) often avoid surgery due to concerns of the potential maternal and fetal risks. Percutaneous transhepatic gallbladder drainage (PTGBD) can serve as an alternative to emergent cho...

A novel prognostic score based on carbohydrate antigen 125, alpha-fetoprotein and carcinoembryonic antigen for Predicting postoperative prognosis in endometrial cancer: Results from a retrospective cohort study

Endometrial cancer (EC) is a common gynecological malignancy with increasing incidence. While several serum biomarkers have been studied for EC, their combined prognostic value remains unclear. This study aimed to evaluate the prognostic significance of preoperative serum CA125,...

A review of pretreatment and analytical techniques for amphetamine type stimulants in complex samples

Amphetamine-type stimulants (ATSs) are among the most widely abused drugs globally, posing serious threats to public health through addiction, physical and psychological harm, and associated social problems such as increased crime rates. Effective clinical management of ATSs over...