China Medical University

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

A scoping review of non-pharmacological symptom management in head and neck cancer patients during the peri-chemoradiotherapy period

Head and neck cancer (HNC) is a globally prevalent malignancy. However, HNC therapies often induce distressing symptoms that impair patients quality of life and treatment adherence. While non-pharmacological interventions are guideline-recommended for symptom management, a compre...

Physiological Occlusal Force Promotes Heme Oxygenase-1 to Repair Periodontal Injury in a Rat Model of Replanted Teeth

Objective The physiological occlusal force generated by mastication plays a critical role in tooth replantation after complete avulsion by promoting periodontal ligament healing. Heme oxygenase-1 (HO-1), a classical cytoprotective factor, exhibits mechanoresponsive expression in...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Community Interactions and Extracellular Riboflavin Are Associated with Oral Biofilm-Mediated Medical Stainless Steel Corrosion

Microbiologically influenced corrosion (MIC) at oral biomaterial interfaces is viewed as an ecological phenomenon, yet how microbial composition and interspecies interactions shape corrosion remains unclear. Here, we investigated whether oral microbial community composition and i...

STAT3/NF-κB signaling axis in macrophage and myeloid-derived suppressor cell driven immune evasion in lung cancer

Immune checkpoint blockade (ICB) has brought transformative advances to lung cancer management; nevertheless, immunosuppressive tumor microenvironment (TME)-mediated therapeutic resistance constitutes a prominent unsolved bottleneck, mainly originating from the sustained buildup...

Quo vadis? – Visualizing the tropism of tumor-derived cellular nanovesicles

Small extracellular vesicles (sEVs) and nanovesicles (NVs) derived from tumor cells hold great potential for targeted drug delivery due to their inherent tumor-homing properties. This study aimed to comparatively evaluate the physicochemical characteristics, cellular uptake, phar...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...

From gingiva to brain: cadmium promotes stroke via vascular mechanisms in periodontitis while vitamin k protects

Abstract Aim To investigate systemic circulatory vascular immune mediators associated with the periodontitis–stroke link and to elucidate underlying cellular mechanisms. Methods We analyzed 4,164 adults from NHANES 2009–2014 using multivariable regression, restricted cubic spline...

Associations of CLivD score with dementia, cardiovascular disease, cancer, and mortality in the general population from the UK biobank

Abstract Background The Chronic Liver Disease (CLivD) score is a non-invasive marker of advanced liver disease risk. We evaluated its associations with dementia, cardiovascular disease (CVD), cancer, and all-cause mortality. Methods This prospective cohort study included UK Bioba...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study

Objectives This community-based, cross-sectional study aimed to evaluate the association of calf circumference and body mass index (BMI) with sarcopenia in older adults with chronic kidney disease (CKD).Methods: Community-dwelling adults aged ≥60 years were enrolled in New Taipei...

Emerging and Re‐Emerging Viral Pathogens in Oncolytic Virotherapy: A Comprehensive Review

Oncolytic virotherapy has recently emerged as a promising immuno-oncological strategy, utilising the natural cytolytic potentials of viral pathogens to selectively target and destroy malignant cells. Although various engineered viruses, such as adenoviruses, vaccinia virus, and h...

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Benchmarking of pathology foundation models for assessing HER2 amplification and CEP17 polysomy in breast cancer

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) amplification and Chromosome 17 (CEP17) copy number is critical for breast cancer treatment, yet diagnostically equivocal (IHC 2+) cases remain a clinical bottleneck. This study systematically benchma...

Efficacy and evidence certainty of traditional Chinese exercises for musculoskeletal disorders: an umbrella review of meta-analyses

Objectives To comprehensively evaluate the efficacy and exercise prescription parameters of traditional Chinese exercises (TCEs) on health outcomes in patients with musculoskeletal disorders (MSDs) and rigorously assess the certainty of the evidence. Design Umbrella review. Data...

Intrinsic capacity decline and multilevel intervention needs of disabled older adults in nursing homes: a qualitative study based on the social-ecological systems theory

Intrinsic capacity (IC) is a central pillar of healthy ageing. Diminished IC is closely associated with poorer health outcomes and a greater degree of care dependence among disabled older adults. This study used the social-ecological framework to examine lived experiences and int...

Pretreatment creatinine-to-cystatin C ratio as a prognostic marker in solid cancers: a systematic review and meta-analysis with trial sequential analysis and reconstructed time-to-event validation

The creatinine-to-cystatin C ratio (CCR) has been proposed as an indirect laboratory marker related to muscle mass and systemic health status. This systematic review and meta-analysis evaluated the association between pretreatment CCR and survival outcomes in patients with solid...

Association of prenatal exposure to PM2.5 and its chemical constituents with early childhood obesity: A population-based study

A growing body of evidence links gestational fine particulate matter (PM 2.5 ) exposure to elevated childhood obesity risk, yet research on the combined impacts and respective contributions of different PM 2.5 chemical constituents remains limited. This large population-based pro...