China Medical University

AI-Driven Self-Powered Wearable Sensors for Gait Detection

Abstract Against the backdrop of rapid advancements in wearable biosensing technology, hydrogel-based triboelectric nanogenerators (TENGs) have garnered significant attention due to their flexibility and self-powered sensing capabilities. However, TENGs still face numerous obstac...

Design and functional verification of an automated Perkins Brailler accessory with audio feedback

PURPOSE: This study presents a proof-of-concept automated accessory designed to actuate selected functions of a standard Perkins Brailler. MATERIALS AND METHODS: The prototype uses push-type electromagnetic solenoids to operate the Brailler keys, a gear motor to support carriage...

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Mitochondria play a crucial role in cellular energy metabolism. The heart and brain require a continuous and stable energy supply. Energy production strongly depends on proper mitochondrial function. Mitochondrial fusion and fission, known as "plasticity", are vital for maintaini...

A web-based interpretable machine learning model for immediate postoperative delirium risk stratification in elderly patients undergoing colorectal cancer surgery

Postoperative delirium (POD) is a serious complication among elderly patients undergoing colorectal cancer surgery, yet accurate and clinically interpretable risk stratification remains challenging. This study aimed to develop and validate an interpretable machine learning (ML) m...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

The IGF2BP3/circDock1/TCF21 axis relieves chronic cerebral ischemic injury by regulating neuronal ferroptosis

Ferroptosis, a form of cell death driven by iron and lipid damage, exacerbates brain injury during chronic cerebral ischemia. However, its precise regulatory mechanisms remain poorly understood. Here we show that the RNA-binding protein IGF2BP3 suppresses neuronal ferroptosis in...

CYP2S1: a novel regulator of PMN-MDSC recruitment and immunotherapy resistance in esophageal squamous cell carcinoma

Chemoimmunotherapy resistance significantly limits the clinical management of esophageal squamous cell carcinoma (ESCC). To identify tumor-intrinsic regulators associated with an immunosuppressive tumor microenvironment (TME) and treatment failure, we integrated proteomic profili...

Estimated lifetime risks of major gynecologic cancers across 185 countries in 2022: life-course patterns and social inequalities

We compared lifetime incidence and mortality risks of cervical, ovarian, and endometrial cancers across 185 countries using GLOBOCAN 2022 estimates and United Nations World Population Prospects 2022 data. Lifetime incidence risk (LRI) and lifetime mortality risk (LRM) were estima...

Species-Dependent Citrus–Simvastatin Interaction Profiles in an Acute Rat Model: Integrating Drug Disposition, Hepatic Redox, and Complementary Computational Analysis

Abstract Citrus species differ widely in flavonoid chemistry, yet grapefruit has come to represent the genus in citrus–statin interactions. To test whether this translates into species-dependent interaction profiles, six flavonoid-profiled citrus peel extracts (Citrus limon, C. d...

Single versus triple low-molecular-weight hyaluronic acid injection strategies with shockwave therapy for rotator cuff lesions: A randomized study with an exploratory historical comparator

Background Rotator cuff lesions without full-thickness tear commonly cause shoulder pain and functional limitation. Hyaluronic acid (HA) injections and extracorporeal shockwave therapy (ESWT) are widely used conservative treatments, but the optimal HA dosing strategy combined wit...

External validation of AI assisted colposcopy using WHO dataset for cervical precancer and cancer detection

Artificial intelligence (AI)-guided colposcopy has previously been developed to assist colposcopists in detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and guiding biopsies, but internal testing of the AI model could overestimate diagnostic performance. We v...

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

Abstract Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD). To address the limited brain penetration of our earlier lead ZJCK-6...

Artificial intelligence for microsatellite instability detection in precision oncology: a systematic review from 2015 to 2025

Abstract Microsatellite instability (MSI) and mismatch repair deficiency (dMMR) are clinically actionable biomarkers that guide immunotherapy selection and prognostic stratification across multiple solid tumors. Polymerase chain reaction (PCR), immunohistochemistry (IHC), and nex...

The potential effects, mechanisms and translational perspectives of natural products in the treatment of atopic dermatitis

Abstract Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder with a continuously increasing global incidence. Current therapeutic options are often associated with adverse effects. In recent years, natural products have attracted considerable attentio...

Nonsurgical Platelet Membrane-Decorated Gold Yarnball Brain Antenna for In Situ Nitric Oxide Generation and Neuronal Regeneration

Bioelectronic implants for brain stimulation are widely used to treat neurological disorders and promote neuronal repair; however, their clinical application is limited by invasive surgical implantation. To address this challenge, here, platelet membrane-decorated gold yarnballs...

Latent classes and determinants of depressive and anxiety symptoms among older adults with chronic diseases in rural China

The mental health of older adults with chronic diseases in rural, underdeveloped regions of China poses a critical public health challenge. Comorbid depressive and anxiety symptoms are highly prevalent but exhibit substantial heterogeneity, necessitating person-centered approache...

MCM10, regulated by METTL3/ YTHDF1-mediated m6A modification, contributes to colorectal cancer progression through induction of M2 macrophage polarization

Abstract Colorectal cancer (CRC) remains a major contributor to cancer-related mortality worldwide. Although minichromosome maintenance protein 10 (MCM10) is known for its role in DNA replication, its involvement in CRC progression has not been fully elucidated. To identify key o...

Machine Learning Model for Predicting Hepatocellular Carcinoma Development in Patients With Hepatitis B Virus‐Related Cirrhosis Receiving Antiviral Therapy

Few prediction models have been specifically designed to evaluate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B and cirrhosis. This study aimed to develop a machine learning-based prediction model to assess the risk of developing HCC in patients...

Gender-Role Identity as Moderators Between Class Environment and Aggressive Behaviors Among Chinese Children

School violence is a major global public health issue that has received increased scrutiny in recent times. Prior studies have indicated that variations in aggressive behaviors among students are associated with factors such as gender-role identity and class atmosphere. However,...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...