China Medical University

MORC2-Mediated Glutamine Metabolic Remodeling Regulates Tumor-Associated Macrophage Function and Immunotherapeutic Responses in NSCLC

Non-small cell lung cancer (NSCLC) frequently exhibits primary or acquired resistance to PD-1/PD-L1 blockade, partly because of the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) are a major immune-cell population in NSCLC and contribute to tumor pr...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Developing nonlinear time-varying weighted combined prediction framework for infectious diseases: validation with respiratory infectious diseases and sexually transmitted infections

Traditional combined prediction models often face limitations in their ability to capture complex nonlinear relationships and weighting. To address these challenges, we propose a nonlinear time-varying weighted combined prediction framework that integrates deep learning algorithm...

Traumatic brain injury in African urban centers: The role of road traffic accidents, outcomes, and health-system factors: a systematic review

Abstract Background Traumatic brain injury (TBI) is a major cause of death and disability in low- and middle-income countries, particularly in rapidly urbanizing regions of Sub-Saharan Africa. Road traffic accidents (RTAs), especially motorcycle-related crashes, represent a leadi...

Hyperbaric oxygen therapy modulates immune aging in a personalized manner: a linear mixed-effects analysis

Abstract Background Immunosenescence, characterized by telomere shortening, senescence-associated T-cell subsets, and chronic inflammation, is a hallmark of biological aging. Whether these aging-related immune biomarkers can be modulated through short-term intervention and whethe...

Decoding how macronutrients influence depressive symptoms: Combined insights from regression, nonlinear modeling, and machine learning: a cross-sectional study using NHANES data

Dietary management is an essential component of comprehensive depression care;however, studies simultaneously evaluating multiple macronutrients and their associations with depressive symptoms are limited. Data from National Health and Nutrition Examination Survey 2005 to 2023 we...

A machine learning-derived dietary pattern for aging

Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis a...

Associations of beans, bean products, and soy isoflavone intake with chronic kidney disease: a cross-sectional study

Abstract Background Current evidence on the association between beans and bean products intake and chronic kidney disease (CKD) remains limited. In vitro and animal studies suggest that soy isoflavones exhibit antioxidant and anti-inflammatory properties, potentially conferring r...

AP-1-IL-1β signaling pathway on impulsive-like behavior and memory deficits in aged mice under tibial plateau fracture conditions

Tibial fracture surgery has attracted significant interest as a notable trigger for PND. Under external stimuli such as anesthesia and surgery, the transcription factor AP-1 regulates the abnormal expression of glutamatergic neurons via interleukin-1β (IL-1β), a mechanism closely...

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles

During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3...

Thyroid function and hypertensive disorders of pregnancy: Insights from a sex‐specific cohort study, Mendelian randomization, and experimental validation

OBJECTIVE: To investigate the association of a history of hypertensive disorders of pregnancy (HDP) and a higher risk of cardiovascular disease using a sex-specific cohort study, bidirectional two-sample Mendelian randomization (MR), and in vitro experiments. METHODS: Multivariab...

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing prec...

An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1–C3–TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages

Background Rheumatoid arthritis (RA) is driven in part by hyperactivated fibroblast-like synoviocytes (FLS) that invade articular structures. Iguratimod (IGU), a conventional synthetic DMARD, is clinically effective, but its direct molecular target and impact on synovial cell-cel...

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Elevated phosphatase and tensin homolog (PTEN) expression is observed in Alzheimer's disease (AD) brain, yet the precise mechanism through which PTEN contributes to AD progression remains undefined. This study provides the direct evidence that PTEN promotes neurodegeneration by d...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...

Intra-amniotic transplantation of APOM-modified BMSCs facilitates neural repair in spina bifida by improving vascular endothelial integrity

Spina bifida aperta (SBA) is the most common type of neural tube defects. Although advances in fetoscopy have enabled fetal surgery to offer significant advantages over postnatal repair, the therapeutic efficacy for motor function impairment remains limited. Previously, we observ...