China Medical University

LncRNA RBMS3-AS3 promotes ovarian cancer progression by regulating QKI and RBFOX2

Long non-coding RNAs (lncRNAs) exert pivotal regulatory functions in the malignant progression of ovarian cancer. Despite this, the biological roles and underlying molecular mechanisms of lncRNA RBMS3-AS3 in ovarian cancer pathogenesis have yet to be fully elucidated. RBMS3-AS3 i...

Preclinical characterization and first-in-human phase I dose-escalation results with JYB1907, a novel anti-GARP-TGF-β1 complex monoclonal antibody in patients with advanced solid tumors

Transforming growth factor-β1 (TGF-β1) promotes immunosuppression in the tumor microenvironment via the GARP-latent TGF-β1 complex on regulatory T cells. JYB1907 is a humanized IgG4 monoclonal antibody targeting this complex. Preclinically, JYB1907 bound GARP-latent TGF-β1 comple...

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

Gastric serum biomarkers for long-term risk stratification of gastric and extra-gastric cancers: a 26-year cohort study

Gastric serum biomarkers are established for gastric cancer risk assessment, but their utility for extra-gastric malignancies and long-term risk stratification remains unexplored. We prospectively evaluated serum pepsinogens (PGI, PGII), gastrin-17 (G-17) and anti- H. pylori IgG...

Molecular mechanism of S100A11 inhibiting anti-HCC immune function of NK cells

Objective To explore the regulatory role and underlying molecular mechanism of S100A11 in the anti-hepatocellular carcinoma (HCC) function of natural killer (NK) cells, and to provide a novel target and theoretical basis for optimizing immunotherapy for HCC. Methods The expressio...

Chiral Solid-State Nanopores Amplify Secondary Interactions for Ionic-Current Discrimination of Neurotransmitter Enantiomers

Abstract Single-molecule ionic-current sensing provides a powerful electroanalytical route for resolving small-molecule enantiomers, yet reliable discrimination remains difficult when stereochemical differences generate only weak and transient interfacial interactions. Here, we e...

Reprogramming the periodontal microenvironment: MOF-hydrogel composites as emerging platforms for periodontitis therapy

Periodontal microenvironment is maintained collaboratively by the oral microbiota, host immune defense, and tissue remodeling. In periodontitis, oral dysbiosis disrupts this physiological equilibrium, precipitating irreversible destruction of periodontal supporting tissues. Curre...

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

ABSTRACT The early‐stage hippocampal development depends on precise synaptic remodeling, processes where microglia play indispensable roles. Disruption of this event reshape hippocampal neural circuit architecture and heighten the risk for long‐term memory, learning, and behavior...

Gut microbiome features in methamphetamine use disorder: external validation of a candidate marker panel and exploratory multi-omics associations

Abstract Methamphetamine use disorder (MUD) is a chronic, relapsing disorder with symptoms most pronounced during withdrawal, yet objective biomarkers remain lacking. Although gut microbial alterations have been reported in substance use disorders, their potential as candidate ma...

The application value of artificial intelligence in medical imaging: foundations, progress, and challenges

Abstract Artificial intelligence (AI) is rapidly transforming medical imaging, reshaping the field as it does everyday life. As imaging data grow in complexity and clinical workloads continue to rise, AI has become increasingly essential for improving diagnostic efficiency and pr...

ESAT-6 and CFP-10 in tuberculosis: bridging virulence to diagnostic applications

Tuberculosis (TB) remains a major global public health challenge. Accurate detection of Mycobacterium tuberculosis ( Mtb ) infection, particularly latent tuberculosis infection (LTBI), is essential for targeted preventive treatment and progress toward TB elimination. The traditio...

PAK4 exacerbates melanoma immunosuppression by promoting exosome release

Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosupp...

Kidney Transplant Recipients’ Experiences of Sleep and Coping Strategies: An Interpretative Phenomenological Study

ABSTRACT Objective To explore the lived experiences of sleep disturbances and coping among kidney transplant recipients (KTRs), thereby providing a basis for developing individualized and targeted nursing interventions. Methods A qualitative study using Interpretative Phenomenolo...

Integrated multi-omics, spatial transcriptomics, and functional studies implicate MDK as a mediator of cisplatin-response phenotypes in ovarian cancer

Abstract Platinum resistance remains a central barrier to durable disease control in ovarian cancer. In this study, we integrated an ovarian cancer susceptibility GWAS, multi-omics profiling (CPTAC/TCGA), and spatial-single-cell transcriptomics to identify novel therapeutic targe...

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Abstract Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addi...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Targeting Tumor–CAFs Crosstalk to Reverse Drug Resistance and Immunosuppression Through Cuproptosis

ABSTRACT Chemotherapy resistance and immunosuppression are the current key bottlenecks in tumor treatment. In the tumor microenvironment (TME), cancer‐associated fibroblasts (CAFs) secrete dense extracellular matrix and various immunosuppressive factors, forming a dynamic “tumor–...

Digital health interventions across the cancer control continuum: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Given the rising global cancer burden and fragmented evidence on digital health interventions (DHIs), this umbrella review synthesizes evidence on DHIs across the cancer control continuum to inform evidence-based practice. We systematically searched PubMed, Medline (via Ovid), We...

Digital symptom management interventions for patients with head and neck cancer during peri-chemoradiotherapy: a scoping review using the UK Medical Research Council Framework

Patients with head and neck cancer experience a substantial symptom burden that severely affects their quality of life during peri-chemoradiotherapy. Digital health interventions offer a promising approach for symptom management. However, such interventions are often hindered by...

CPEB4 mediated EZH2 dependent beclin1 methylation affecting neuronal ferroptosis in epilepsy

Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) regulates protein expression by modulating mRNA translation and stability. Previous investigations have reported adaptive upregulation of CPEB4 in epilepsy, and knockout of the CPEB4 gene aggravates status epilepticus...