Chengdu University of Traditional Chinese Medicine

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

Oral Edible Zein/CitricAcid Nanocomposite EnablesIntestinal Delivery of Resveratrol for Effective Ulcerative ColitisTherapy

Abstract Resveratrol (Res) is a plant polyphenol with diverse bioactivities, yet its application is limited by poor water solubility and low bioavailability. Therefore, an edible nanodelivery system composed of a zein/citric acid complex was developed to encapsulate Res@ZC-NPs sh...

Impact of IL-6 receptor inhibitors on cerebrospinal fluid metabolites in type 2 diabetes patients

This study aimed to investigate whether interleukin-6 (IL-6) receptor inhibitors affect cerebrospinal fluid (CSF) metabolites in type 2 diabetes (T2D) patients. The initial phase employed drug-targeted Mendelian randomization to investigate the association between IL-6 receptor i...

Discovery, Synthesis,and Biological Evaluation of1,3,4,5-Tetrahydro-6 H -pyrano[4,3- c ]isoquinolin-6-one Derivatives as Novel and Highly SelectivePARP1 Inhibitors

Abstract Developing highly selective PARP1 inhibitors is a promising strategy to improve the therapeutic window compared with dual PARP1/2 inhibitors. Through structure-guided design and optimization, we developed (R)-A17, a novel, highly selective PARP1 inhibitor featuring a uni...

Assessing the interactive effects of land use and climate change on species assemblages of giant panda and its sympatric large- and medium-sized terrestrial mammals

Land use and climate change are currently two most important drivers of biodiversity loss worldwide. Although the effect of these two drivers on species assemblages has been widely assessed both in isolation and in combination, their interactive effects (i.e., additive, synergist...

Toxic effects of streptozotocin (STZ)-induced zebrafish and the response mechanism of liver transcriptome

Streptozotocin (STZ) is commonly used to induce diabetes, but its efficacy and systemic toxicity in zebrafish remain controversial. This study evaluated the dose-dependent effects of STZ in adult zebrafish and explored the molecular mechanisms underlying hepatotoxicity using tran...

Comparative therapeutic effects of the proximal femoral bionic nail (PFBN), PFNA, and InterTan for intertrochanteric fractures: a systematic review and network meta-analysis

This study aimed to compare the efficacy of the proximal femoral bionic nail (PFBN), proximal femoral nail antirotation (PFNA), and InterTan in the treatment of intertrochanteric fractures. This network meta-analysis was conducted in accordance with the PRISMA 2020 statement and...

Exposure-informed lung transcriptomic analysis links predicted NNK targets to cell type-specific remodeling programs in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is associated with cigarette smoking, yet the relationship between the tobacco-specific nitrosamine nicotine-derived nitrosamine ketone (NNK) and IPF-associated lung transcriptional remodeling remains incompletely understood. Here, we developed...