Chengdu University of Traditional Chinese Medicine

Auditory brainstem response deficits precede and are associated with subsequent auditory cortical amyloid burden in male APP/PS1 mice

Background Auditory dysfunction is considered one of the early manifestations of Alzheimer's disease (AD). However, its evolutionary characteristics with the progression of AD have not been fully studied, and the temporal relationship between this sensory impairment and the typic...

MicroRNA-2110 acts as a tumor suppressor in gastric cancer via direct targeting of IGF1R

Abstract Background MicroRNA-2110 has been implicated in cancer, but its expression and function in gastric cancer (GC) remain understudied. This study aims to explore the role of miR-2110 in GC and its regulation of IGF1R. Methods RT-qPCR was used to measure miR-2110, IGF1R expr...

The prevalence of major adverse cardiovascular events after hip fracture surgery in older adults: a systematic review

The reported incidence of major adverse cardiovascular events(MACE) following hip fracture surgery in older adults remains unclear, with existing studies exhibiting substantial heterogeneity. We conducted a systematic review in accordance with PRISMA 2020 guidelines. PubMed, Web...

Semi-recumbent position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation

RATIONALE: Ventilator-associated pneumonia (VAP) is associated with increased mortality, hospital stay, and healthcare costs in critically ill patients. Although guidelines recommend a semi-recumbent position for VAP prevention, the evidence remains uncertain due to limitations i...

Association of the Dietary Inflammatory Index with bone mineral density and osteoporosis among adults with type 2 diabetes

Dietary inflammatory load, quantified using the Dietary Inflammatory Index (DII), reflects pro-inflammatory dietary patterns that may contribute to impaired bone health. However, population-based evidence regarding the association between dietary inflammatory potential and bone m...

Dose–response associations of the composite dietary antioxidant index and related nutrients with prevalent chronic kidney disease: NHANES 2003–2018

Oxidative stress is implicated in kidney dysfunction, but population-based evidence linking dietary antioxidant profiles to prevalent chronic kidney disease (CKD) remains limited. We examined associations of the composite dietary antioxidant index (CDAI) and selected antioxidant-...

MH-Penile-002: a phase II, prospective, single-arm trial of neoadjuvant anti-EGFR antibody-drug conjugate plus PD-1 inhibitor in penile cancer with challenging penile preservation or regional lymph node metastasis

Emerging evidence suggests that combinations of antibody-drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs) may be effective for advanced penile squamous cell carcinoma (PSCC). These findings support the translation of this strategy into the neoadjuvant setting, offer...

The combination of farnesol and berberine effectively inhibits Candida albicans growth and biofilm formation

Abstract The formation of Candida albicans biofilms is a key factor contributing to clinical antifungal treatment failure and multidrug resistance (MDR). Overcoming biofilm formation is an urgent priority in antifungal therapy. Here, we report a synergistic strategy utilizing far...

MUCL1 functions as a tumor suppressor in skin melanoma by inhibiting epithelial–mesenchymal transition

This study aims to analyze the global burden of skin melanoma from 1990 to 2021 and explore the clinical significance and mechanistic role of Mucin-Like Protein 1 (MUCL1) in the metastasis of skin melanoma. Global burden data from 1990 to 2021 were extracted from the Global Burde...

Correlation of bevacizumab relative dose intensity with first-line treatment outcomes in advanced epithelial ovarian cancer

Objective: To evaluate the association between bevacizumab relative dose intensity (RDI) and first-line treatment outcomes in advanced epithelial ovarian cancer.Methods: We retrospectively analyzed 72 patients treated with first-line bevacizumab plus paclitaxel-platinum chemother...

Dietary and Formulation Potential of Natural Oils and Fats in Ocular Health and Disease: Mechanisms, Evidence, and Future Directions

Natural oils and fats are multicomponent lipid matrices composed predominantly of triacylglycerols with source-specific fatty-acid profiles, together with variable amounts of phospholipids and minor lipophilic constituents. This narrative review discusses the nutritional, biologi...

Cell Type–Resolved Causal Inference and Spatial Transcriptomic Integration Reveal Immune‐Specific Genetic Drivers of Autoimmune and Malignant Thyroid Disease

ABSTRACT Background : Thyroid diseases, including autoimmune thyroid disease (AITD) and thyroid cancer, are characterized by immune dysregulation, yet the cell type–specific genetic mechanisms underlying these conditions remain poorly understood. Most genome‐wide association stud...

Kaempferol as a dietary guardian against gastric carcinogenesis: Breaking the Correa's cascade at multiple junctions

Correa's cascade outlines the dynamic progression of gastric carcinogenesis, from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG), gastric precancerous lesions, and finally gastric cancer (GC). A natural compound, kaempferol (KAE), abundant in many fruit...

Comparative performance of ChatGPT-4.0, DeepSeek, Gemini and Perplexity in answering common questions from patients with COPD

Abstract Large language models (LLMs) may help with patient education, but clinicians must check LLM responses for accuracy, comprehensiveness, readability, and safety. This study compared responses from the LLMs ChatGPT-4.0, DeepSeek, Gemini, and Perplexity to 20 English-languag...

Cost-effectiveness analysis of durvalumab combined with tremelimumab versus sorafenib as first-line treatment for unresectable Hepatocellular carcinoma in China: a dual-model approach utilizing partitioned survival and markov models

Abstract Background Hepatocellular carcinoma (HCC) is a major contributor to global cancer-related mortality, with the majority of patients diagnosed at unresectable stages. The STRIDE regimen (tremelimumab plus durvalumab) demonstrated superior survival benefits over sorafenib i...

A CCCTC-binding factor (CTCF)-fatty acid desaturase 1 (FADS1) axis regulates oncogenic energy metabolism in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein crucial for 3D genome organization and gene regulation. Previous studies have shown that CTCF overexpression in hepatocellular carcinoma (HCC) is associated with poor prognosis. This study aimed to elucidate th...

Regional ventilation at EIT-guided PEEP and mortality in severe ARDS: a prospective observational study

Severe acute respiratory distress syndrome (ARDS) is characterized by regional mechanical heterogeneity and systemic inflammation. Electrical impedance tomography (EIT) can individualize positive end-expiratory pressure (PEEP), but the prognostic value of EIT-derived variables me...

Bibliometric mapping of scientific production on maturity-onset diabetes of the young: evolution, hotspots, and future directions

Abstract Background Maturity-onset diabetes of the young (MODY) is the most common form of monogenic diabetes, with genetic and clinical heterogeneity emerging as significant challenges. Despite growing scholarly attention to MODY research, the overall knowledge structure, resear...

Novel Ophiopogon japonicus polysaccharide prevents chronic atrophic gastritis via gut microbiota/indole-3-acetic acid/AHR-CYP1A1-NF-κB axis

Ophiopogon japonicus (L. f.) Ker Gawl ., a traditional food ingredient in China with recognized benefits for gastric comfort, is commonly consumed in soups and herbal teas. Polysaccharides, the principal bioactive constituents, are promising candidates for dietary supplements and...

Development of a digital teaching competency model for medical faculty: a multi-stage mixed-methods study using a modified Delphi approach

Digital teaching competency among medical faculty is essential for promoting high-quality development in medical education. Although existing frameworks, such as the European Framework for the Digital Competence of Educators, have provided a foundation for research on teacher dig...