Chengdu University of Traditional Chinese Medicine

Worldwide Changes in Loneliness Among Older Adults From 1997 to 2025: A Cross-Temporal Meta-Analysis and Systematic Review

Objectives: Loneliness is a critical psychosocial factor associated with mental health and wellbeing in later life. Although prior research has documented its prevalence, less is known about how loneliness has changed over time at a global level or how broader societal conditions...

HIV-tuberculosis co-infection in Liangshan, a resource-limited region of Southwest China: trends and implications in the context of integrated prevention, 2019–2024

Abstract Background Tuberculosis (TB) and HIV co-infection remains a major public health challenge in resource-limited settings. Liangshan Yi Autonomous Prefecture in Southwest China bears a dual high burden of HIV and TB. This study aimed to analyze the epidemiological trends of...

Penicillium- mediated toxicity and microbial dysbiosis are associated with fruiting body abortion in artificially cultivated Chinese cordyceps

‑mediated toxicity, microbial imbalance, and developmental disorders of Chinese cordyceps.

A dynamically coordinated bioactive MOF-hydrogel system for ternary microenvironment reprogramming in MRSA-infected diabetic wounds

Due to a persistent inflammatory response, excessive accumulation of ROS, and MRSA infection, the repair of diabetic chronic wounds faces severe challenges. Here, an intrinsically bioactive MOF-hydrogel system (SR@P/L) was designed to accelerate wound healing by reprogramming the...

Traditional Chinese medicine monotherapy in extensive-stage small cell lung cancer

Rationale: Small cell lung cancer (SCLC) is a highly aggressive malignancy. It typically advances quickly, spreads distantly at an early stage, and carries a dismal prognosis, factors that collectively present formidable obstacles to effective treatment. To date, evidence regardi...

Comparison of lumbar interbody fusion with PEEK cage, titanium-coated PEEK cage and 3D-printed porous titanium cage for the treatment of lumbar degenerative disease: a systematic review and network meta-analysis

Abstract Background As two classic representative materials, solid titanium cages and uncoated PEEK cage (UPC) each have distinct inherent advantages and limitations, and 3D-printed porous titanium cage (3DPPTC) and titanium-coated PEEK cage (TCPC) have been increasingly applied...

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4 /Myd88/ MAPK Pathway Inhibition

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits. This study aimed to investi...

Icariin: Unraveling Ferroptosis Mechanisms, Metabolic Networks, and Innovative Therapy Strategies

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. This concept reshapes our understanding of tissue degenerative lesions and oncogenesis. Icariin (ICA) is an isoprenyl flavonol glycoside derived from plants of the genus Epimedium. Acting as a bidir...

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Natural pollen-derived microcapsules as high-performance auxiliary cleaning particles for personal care

Effective removal of sebum, cosmetic residues, and environmental impurities is essential for high-performance personal cleansers. Nevertheless, developing functional auxiliary cleaning particles with both environmental friendliness and high cleansing performance remains a major c...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Systematic Screening of Depression-Related Neurotoxicity Across 26 Bisphenols Reveals an ESR1–CREB1–GRIN2B-Associated Mechanism

Bisphenols (BPs) are widespread environmental endocrine disruptors, but their potential depression-related neurotoxicity has not been systematically assessed. Here, we combined machine learning (ML), network toxicology, molecular docking, and in vivo experiments to screen 26 bisp...

Diagnostic value of anti-carbamylated protein combined with Anti-RA33 antibodies in seronegative rheumatoid arthritis: a retrospective cohort study

Seronegative rheumatoid arthritis (SNRA), defined by the absence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), poses a persistent diagnostic challenge. Anti-carbamylated protein antibodies (Anti-CarP-IgG) and anti-RA33 antibodies targeting heterogene...

Recent Advances in Comprehending Endothelial Dysfunction and Diabetic Cardiomyopathy: From Molecular Mechanisms to Clinical Applications

Diabetic cardiomyopathy (DCM) is a cardiac condition characterized by various structural and functional abnormalities that are associated with diabetes mellitus. Its development involves multiple factors, among which endothelial dysfunction plays a significant role. To fully desc...

Efficacy and safety of repeated low-level red light therapy in myopia control: an updated and comprehensive systematic review and meta-analysis

This study aims to assess the therapeutic effectiveness and safety of repeated low-level red light for myopia management in children and adolescents. Multiple databases were systematically searched for studies evaluating the efficacy of RLRL in myopia control among children and a...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

taVNS for uterine contraction pain and early recovery after spontaneous vaginal birth: a three-arm randomized controlled trial protocol

Uterine contraction pain after spontaneous vaginal birth (SVB) hinders early maternal recovery. Transcutaneous auricular vagus nerve stimulation (taVNS), as a safe, and non-invasive alternative therapy, can alleviate pain and improve sleep and emotion. Although a recent trial has...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...