Centre National de la Recherche Scientifique

The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey

Abstract Rare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leading to constitutive PKA activation, underlie pr...

Grid4Earth: An Open-Source Python Ecosystem for Geospatial Data Integration Using an Ellipsoidal HEALPix DGGS

Abstract. The rapid growth in Earth observation (EO) and Digital Twin Earth data volumes creates a need for global, reproducible, and cloudnative spatial representations. Conventional latitude–longitude grids and projected tiling systems remain useful, but they introduce projecti...

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will p...

Challenging the predictive coarse-to-fine hypothesis in emotional face perception

Introduction Predictive processing (PP) accounts conceptualize perception as an interaction between top-down predictions and bottom-up sensory inputs. In the visual domain, low spatial frequencies (LSF) convey coarse information, supporting early predictions, refined by high spat...

Six-fold reduction in ocean heat content estimate uncertainty since 1960

Abstract Ocean heat content (OHC) dominates Earth’s energy imbalance, but its uncertainty has not been fully understood. Here, we construct a Large-Ensemble to comprehensively quantify the OHC uncertainty from global to regional scales since 1955, and consider eight groups of err...

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists

Model organisms are central to biological research. Living organisms are models in the sense that the knowledge gained from their study is meant to be generalized. For example, experiments conducted on Drosophila or nematodes bring general knowledge on phenomena such as cell migr...

Automatic Crater Classification Using a Deep‐Learning‐Based Pipeline

Abstract Identifying and classifying impact craters on Mars is crucial for understanding the planet's geological history and surface evolution. Traditional crater classification relies on manual annotation methods, which are often limited by human biases and the difficulty of int...

Convergence Rates for Polynomial Optimization on Set Products

Abstract. We consider polynomial optimization problems on Cartesian products of basic compact semialgebraic sets. The solution of such problems can be approximated as closely as desired by hierarchies of semidefinite programming relaxations, based on classical sums of squares cer...

Environmental drivers of litter- and soil-dwelling springtail communities across European forests, assessed by morphotaxonomy and soil DNA metabarcoding

Springtails are abundant in forest litter and soils, where they play a crucial role in the transformation and decomposition of organic matter. However, most data on springtail communities originates from studies at the local and regional levels, while larger-scale studies are lac...

Addressing anthropogenic noise and electrical anisotropy hints in magnetotelluric data from the Annecy area (French Pre-Alps)

The magnetotelluric (MT) method is a widely used tool for geothermal reservoir exploration due to its capability of imaging fluids in the Earth’s crust. However, in urbanised environments, its application is often challenged by anthropogenic noise and low signal-to-noise ratios....

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Bias in Genome-Wide Association Test Statistics Due to Omitted Interactions

Abstract Over the past two decades, genome-wide association studies (GWAS) enabled the discovery of thousands of variants associated with many complex human traits. However, conventional GWAS are still widely performed with linear models with the assumption that the genetic effec...

Coupling of stable isotope probing and metagenomics reveals the diversity of viruses infecting formatotrophs during anaerobic digestion process

Abstract Background Viruses play a major role in regulating microbial community composition and activity, yet their diversity and host associations in anaerobic digestion (AD)—a complex biotechnological process converting organic waste into biogas—remain poorly characterized. Lin...

Structural Responses of Aluminoborosilicate Glasses to Pressure and Iodine Incorporation: An Advanced NMR Investigation

ABSTRACT Iodine‐129 is a critical challenge for nuclear waste immobilization due to its high mobility and extremely long half‐life (1.57 × 10 7 years). Although high‐pressure glass synthesis has been shown to significantly enhance iodine solubility, the structural mechanisms gove...

Neural network–augmented Pfaffian wave-functions for scalable simulations of interacting fermions

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studyin...

Oak masting under climate change: when spatially heterogeneous shifts in flowering phenology reshape pollen limitation

Masting, the irregular, synchronised production of seeds within tree populations, drives forest regeneration and ecosystem dynamics. Its response to climate change may depend on phenological shifts in key reproductive stages, yet this link remains poorly understood. Using 30 yr o...

Local Trade‐Offs Shape Flower Size Evolution Across Arabidopsis thaliana Distribution

The remarkable variation in floral form and size is thought to have driven the evolutionary radiation of angiosperms and has traditionally been attributed to pollinator-mediated selection on floral displays, yet emerging evidence indicates that abiotic environmental factors can a...

Porous and Permeable Crystalline Basement: Evidence for Large‐Scale Hydraulic Connectivity at Kivetty, Finland

Abstract Porosity and permeability in crystalline shield basement are commonly assumed to be low, yet some fault zones sustain fluid circulation over kilometer scales. Here we quantify multiscale fault‐zone connectivity at Kivetty, central Finland, by integrating legacy deep‐bore...

Fewer players, bigger opportunity: How structural rule modifications shape physical and technical demands in youth rugby union

Purpose Youth rugby governing bodies have progressively revised competition formats to align game demands with children's developmental characteristics. However, empirical evidence remains limited on whether these structural modifications increase children's locomotor and technic...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...