Centre National de la Recherche Scientifique

Coupling between statistical learning and interference suppression

Abstract In an ever-changing environment, synchronizing automatic and controlled behaviors is essential for successful adaptation. Yet, the relationship between these behaviors is often debated, partly because of the diverse approaches used to investigate them. The present study...

Beyond wind-induced upwelling: diverse drivers of future productivity in eastern boundary upwelling systems

Abstract. Eastern Boundary Upwelling Systems (EBUS) contribute disproportionately to global marine productivity and fisheries, yet their response to climate change remains poorly understood. Given the essential ecosystem services they support, improving projections of future EBUS...

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged...

Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line

Abstract Hair cells of the zebrafish lateral line have proven to be a good model for studying hair cell function in a system that is easily genetically manipulated, rapidly develops and is experimentally accessible. However, characterization of potential developmental changes, an...

Phylogeny-guided curation reveals widespread misannotation of Asgard archaeal 16S rRNA gene sequences in public databases

Abstract Accurate taxonomic assignment of 16S rRNA gene sequences is essential for the reliable interpretation of microbial community studies based on amplicon sequence data. Yet, it critically depends on the reliability of reference databases such as the Genome Taxonomy Database...

Hippocampal volume changes in astronauts and bilateral vestibulopathy patients

Abstract The hippocampus is a particularly plastic and vulnerable brain structure. Given the modulatory role of the vestibular system on hippocampal function, we hypothesized that altered vestibular stimulation associated with prolonged spaceflight could lead to similar hippocamp...

Understanding positive affect in Angelman syndrome: Smiling and laughter across comparison groups

Angelman syndrome (AS) is a neurogenetic condition marked by frequent smiling and laughter. Early descriptions portrayed these expressions as inappropriate or disconnected from context, but recent work has questioned this view. This study examined the emotional responses of child...

Hydraulic function of medullary bundles in a tropical root climber

Abstract Premise Medullary bundles, which are vascular bundles in the pith, have evolved multiple times. However, their functional significance remains poorly understood. Here, we investigated how medullary bundles are involved in the vascular architecture and hydraulic function...

The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics

Abstract The shape of animal cells is controlled by their surface, which comprises the cell cortex, a peripheral actin network, tethered to the plasma membrane by membrane-to-cortex attachment proteins. Changes in cortical components have long been considered to dominate the regu...

A nested factor model for equity markets: reconciling multifractal stock returns and rough index volatilities

The Nested factor model was introduced by Chicheportiche et al. to represent non-linear correlations between stocks. Stock returns are explained by a standard factor model, but the (log)-volatilities of factors and residuals are themselves decomposed into factor modes, with a com...

The 1H, 15N and 13C backbone resonance assignments of an intrinsically disordered region (467–696) of breast cancer type 1 susceptibility protein (BRCA1)

The tumor suppressor protein breast cancer type 1 susceptibility protein (BRCA1) plays a central role in maintaining genome stability through its involvement in DNA damage repair, transcriptional regulation, and cell-cycle control. BRCA1 functions as an obligate heterodimer with...

Multiomics reprogramming reverses disease susceptibility in Magallana gigas during aging

Aging is a progressive and irreversible biological process that typically increases susceptibility to infectious diseases. However, unexpectedly, the opposite outcome was observed in oysters: older oysters exhibit increased tolerance to Pacific oyster mortality syndrome (POMS), a...

Mapping the nuclear environments of extreme coronal line emitting galaxies

Abstract Extreme coronal line emitters (ECLEs) are a rare class of galactic nuclei exhibiting unusually strong high-ionisation forbidden emission lines, and several ECLEs have been linked to tidal disruption events (TDEs). In this work, we compile and analyse optical spectra of 3...

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-spe...

Uneven TCR chain pairing constraints govern epitope recognition

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear...

Perceived time in the presence of others: Further arguments for an attentional view of social facilitation

Although the effects of the presence of others on behavior constitute one of the oldest topics studied in social psychology, the reason why these effects occur is still the subject of scientific debate. Three hypotheses are commonly cited: (1) the presence of others facilitates d...

Learning aligned EEG representations with subject-specific encoders

Cross-subject EEG decoding promises more training data, but it also exposes neural networks to strong inter-subject distribution shifts. We study whether task supervision and architecture alone can learn subject-aligned representations. We replace a shared EEG encoder with subjec...

From fluid loss to calcification: MRI and CT matrix features in cystic echinococcosis

Abstract Objective To characterize MRI matrix signal and CT calcification patterns across WHO-IWGE stages, compare them with lesion mimicking cystic echinococcosis (CE), and derive an MRI-based subclassification for inactive cysts. Materials and methods This retrospective multice...

Noncollinear kagome magnet driven by giant antisymmetric exchange

Kagome lattices host exotic phenomena such as quantum spin liquids, topological Weyl nodes, and flat bands. The kagome ferromagnet Co3Sn2S2 has been a focus of debate due to conflicting reports on its magnetic character. Here, using weakly perturbative probes—primarily neutron sc...

Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI

Abstract The role of cortical oscillations in brain function has been extensively debated, resulting in a variety of theoretical frameworks. Using inter-leaved simultaneous EEG-fMRI, we examined the layer-specific relationship between oscillatory activity and visual processing. W...