Centre National de la Recherche Scientifique

Extreme conditional quantile estimation for time series

Abstract We consider the estimation of an extreme conditional quantile for a heavy‐tailed distribution in the case of a strictly stationary time series . Here, denotes the conditional quantile function of given and is small, i.e., smaller than , where is the size of the sample on...

Projecting Impacts of Marine Heatwaves and Their Effects on Long‐Term Changes in Marine Ecosystems Over the 21st Century

ABSTRACT Marine heatwaves (MHWs) are increasing in frequency, duration and intensity under climate change. Although current MHWs trigger broad ecological impacts, such as coral bleaching, mass mortality of seagrass meadows, and declines in important fish stocks, the cascading eff...

Uncovering the cytotoxicity and growth inhibition of 14 Microcystis extracts on freshwater fish cell lines

Freshwater cyanobacteria raise health and ecotoxicological concerns due to their production of secondary metabolites. The Microcystis genus synthesizes the well-known cyanotoxins, microcystins (MCs), but also various metabolites with documented sublethal and lethal effects. The t...

Decoupling the Role of Nanoparticle Rigidity and Chemistry in Particle Transport through the Brain Parenchyma

Abstract Drug delivery to the brain involves challenging transportation across multiple biological barriers. Despite the great tunability of polymeric nanoparticles, the synthetic challenge of varying the physical property of a nanoparticle without varying its chemical formulatio...

Linear Fluctuation of Interfaces in Glauber–Kawasaki Dynamics

Abstract In this article, we find a scaling limit of the space-time mass fluctuation field of Glauber + Kawasaki particle dynamics around its hydrodynamic mean curvature interface limit. Here, the Glauber rates are scaled by $$K=K_N$$ K = K N (with $$K_N\uparrow \infty $$ K N ↑ ∞...

Efficacy of a digital mental health program for university students: A randomized controlled trial comparing online and hybrid delivery

University students are a high-risk population for mental health problems. However they often face barriers to care. Digital Mental Health Interventions are scalable tools to support well-being, yet evidence regarding optimal delivery formats remains mixed. This study assessed th...

Palliative and end-of-life care on the battlefield: a scoping review

Abstract Background Modern conflicts have brought about a paradigm shift in military medicine. In Prolonged Field Care, recommendations have so far focused on damage control and care aimed at ensuring survival. But, particularly in large scale combat operation, not all patients w...

Experimental investigation of surface inclination effects on ablation of a solid impacted by a hot liquid jet

In sodium-cooled fast reactors (SFRs), the potential consequences of a severe accident with core meltdown are now considered during the reactor design phase. Such events lead to the formation of a corium , a radioactive mixture of molten nuclear fuel and structural materials. Two...

A toolpath-driven design method for continuous fibre-reinforced polymer additive manufacturing of lattice structures

Purpose The purpose of this paper is to develop a toolpath-driven parametric design methodology for additively manufactured continuous carbon fibre-reinforced lattice structures to overcome design difficulties from fibre deposition constraints, enable reinforcement of cellular ar...

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

The emergence of multidrug-resistant (MDR) bacteria necessitates the development of next-generation antimicrobial strategies beyond conventional antibiotics. Upconversion nanoparticles (UCNPs), owing to their anti-Stokes luminescence under near-infrared (NIR) excitation, offer a...

Emergent properties of urban landscapes shape urban eco-evolutionary dynamics

Abstract Context Urbanization transforms natural ecosystems into heterogeneous and fragmented landscapes, creating novel selective pressures that can drive eco-evolutionary dynamics. However, the specific role of urban spatial structure in shaping these dynamics remains poorly un...

What Drives the Selectivity of 5-(Hydroxymethyl)furfural Electroreduction over Copper in Mildly Basic Medium?

Abstract 2,5-Bishydroxymethylfuran (BHMF) is an important bio-based monomer that can be produced via the electrochemical reduction of 5-(hydroxymethyl)furfural (HMF) on Cu electrocatalysts. Under mildly alkaline conditions, however, BHMF formation competes with hydrodimerization...

Impact of a Specialized Care Pathway for ICU Patients With Disorders of Consciousness: Observational Insights From an Expert Center

ABSTRACT Background Management of lasting disorders of consciousness (DoC) is complex and sometimes requires referral of patients to an expert team. We aimed to evaluate the impact of such specialized expert assessment through the description of a single‐center experience. Method...

Uncertainties of GRACE/GRACE-FO Satellite Gravimetry Data and Thereof Derived Products

Abstract Inter-satellite ranging by space gravimetry missions, such as from the Gravity Recovery And Climate Experiment (GRACE) mission and its successor mission GRACE Follow-On, has been established to observe mass variations in the Earth system from space globally. A complex pr...

Hydroalkylation and hydroacylation of trifluoromethyl olefins by N-centered direct hydrogen atom transfer photocatalysis

The selective functionalization of trifluoromethyl olefins, while keeping the essential trifluoroalkyl moiety intact, remains a synthetic challenge. In this study, we report the use of an acridinium amidate as a direct hydrogen atom transfer (d-HAT) photocatalyst for the mild and...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

MARS-RNA: An Automated Pipeline for Correlating RNA Molecular Dynamics Trajectories with Chemical Probing Data

Abstract Ribonucleic acid (RNA) molecules fold into complex, highly dynamic three-dimensional conformational structures that govern their biological activities. Chemical probing methods, such as SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension), provide structu...

Mechanical decoupling epitaxy via compliant microdisks yields relaxed transferable AlGaN across broad compositions

Abstract Achieving high-quality, crack-free AlGaN layers across a wide aluminum composition range is critical for ultraviolet optoelectronics but remains challenging due to strain-induced defects from lattice and thermal mismatches. Here we present a mechanical decoupling epitaxy...

A Review of Input Current Ripple Reduction Techniques in Non-Isolated DC–DC Boost Converters

Input current ripple reduction in DC-DC boost converters is a persistent challenge because input current ripples are driving up filter requirements, electromagnetic interference (EMI), and stress on sources and loads. This ultimately limits power density and efficiency in many ap...

How fluorinated cyclic ether shapes localized high concentration electrolytes

Localized high concentration electrolytes (LHCEs) have emerged as a transformative choice, simultaneously exhibiting good electrochemical stability, sufficiently fast ionic transport, and improved rate capability. The design principle is to dilute the conventional electrolyte wit...