Case Western Reserve University

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...

Developmental dynamics of ovine lung in health and cystic fibrosis at single-cell resolution

Abstract The sheep lung has long been used to model aspects of the human lung, both its normal development and pathological changes that occur in ovine models of lung disease. The similarities between the two species provide an opportunity to investigate phases of lung developmen...

Clinical guidelines addressing complex and ‘wicked’ problems

Clinical guidelines aid decision-making, but their simplifying strength becomes a limitation in complex, value-laden situations. Once meant to summarise evidence, they now function as prescriptive standards used in quality and legal assessments. Overly rigid directives can underm...