Case Western Reserve University

Modeling the heterogeneity of cognitive dysfunction in Parkinson’s disease using partially ordered set models

Abstract Traditional binary classifications of Parkinson’s disease (PD) cognitive dysfunction fail to capture its inherent heterogeneity. This study introduces the Partially Ordered Set (POSET) model, a Bayesian framework, to analyze cognitive heterogeneity using Parkinson’s Prec...

Patient‐Reported Outcome Measures in Musculoskeletal Oncology: Current Concepts, Barriers, and the Future

Patient-reported outcome measures (PROMs) remain underutilized in musculoskeletal oncology, with only 4.9% of tumor-focused articles incorporating them. This review synthesizes current PROM instruments-including Toronto Extremity Salvage Score, PROMIS, and emerging tools such as...

Note on Stochastic Vehicle Routing With Delivery Choice Under Recourse Options

ABSTRACT In this paper, we consider the stochastic vehicle routing problem with delivery choice, where, upon reaching a particular customer, the driver has the choice of how much to deliver once the customer demand is revealed. In our earlier work, a basic version of the problem...

HIV-1 Tat Forms a Dissociable Complex with 7SK snRNP and Exhibits Clade Differences in Reversing the Sequestration of P-TEFb

Recent efforts to employ ectopic Tat as a latency-reversal strategy can benefit from the identification of Tat variants with more efficient transactivation activity. Tat primarily serves as a recruiter of the host transcription elongation factor P-TEFb to proviral HIV to stimulat...

Redefining Kidney Stone Incidence: Emerging Age-Related Patterns

OBJECTIVE: To evaluate the association between age and incident kidney stone disease using contemporary, age- and sex-stratified population-based data from the UK Biobank. METHODS: We undertook a cohort study of 494,745 UK Biobank participants after excluding 7406 individuals wit...

Adaptive landscape of the metallo-β-lactamase NDM-1 to emerging β-lactam-based therapies

ABSTRACT The New Delhi metallo-β-lactamase (NDM) is a major determinant of carbapenem resistance. This has prompted the development of novel therapeutic strategies to treat NDM producers. Since these therapies impose new selective pressures, their clinical deployment may favor ND...

Musculoskeletal MRI Relaxometry Phantom for T1 , T2 , and T1ρ Measurements

ABSTRACT Background Quantitative MRI (qMRI) requires quality assurance methods that reflect in vivo conditions to ensure consistent measurements with low bias and high reproducibility over time, across multiple sites, and across different MRI scanner manufacturers and models. Pur...

Local Scientific Development and Promotion of Scientific Vocations in Africa: The Case of Oilseeds

Abstract This article presents an educational outreach initiative to promote interest in chemistry in Africa by connecting science to economic development. The project uses the transformation of oil from local oilseeds into soap as a concrete example of converting a local natural...

Cross-robot open-set fault detection via normal-only adaptation and residual latent-space alignment

Reliable fault detection and health monitoring of industrial robots are important for smart manufacturing in Industry 4.0. However, robotic platforms differ in their mechanical design, sensing characteristics, and operating conditions. These differences make it difficult for data...

Comparing Three Delivery Formats of a Fatigue Self-Management Intervention: Findings from a Non-Inferiority Randomized Trial

Date presented: April 25, 2026 Primary Author and Speaker: Matthew A Plow, map208@case.edu

sc P rofiterole : Clustering of Single-Cell Proteomic Data Using Graph Contrastive Learning via Spectral Filters

Novel technologies for the acquisition of protein expression data at the single cell level are emerging rapidly. Although there exists a substantial body of computational algorithms and tools for the analysis of single cell gene expression (scRNAseq) data, tools for even basic ta...

Citron kinase activity controls alternative splicing events that drive prostate cancer growth

Prostate cancer (CaP) remains a major cause of cancer death in men, underscoring the need for mechanistically novel therapies. We previously identified the action of the mitotic kinase citron (CIT) kinase as a key driver of CaP progression and promising therapeutic target, but se...

Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates

Influenza A virus (IAV) infection during pregnancy is associated with stillbirth and preterm birth. We hypothesized that maternal IAV infection disrupts placental and fetal immune networks in ways that correlate with disease severity. Pregnant pigtail macaques were inoculated wit...

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Abstract Background: Pancreatic surveillance commonly detects pancreatic cysts, most of which are presumed intraductal papillary mucinous neoplasms (IPMN). FUT2, the gene responsible for secretor status, has been implicated in IPMN development, although not with pancreatic cancer...

Population pharmacokinetics modeling of albendazole and its active metabolite, albendazole sulfoxide in mass drug administration against lymphatic filariasis

ABSTRACT Albendazole (ALB), a benzimidazole antiparasitic, is widely used in mass drug administration (MDA) campaigns against lymphatic filariasis (LF). It is rapidly metabolized to its active form, albendazole sulfoxide (ALB-OX), which exhibits considerable interindividual varia...

Nonlinear Quantum Effects Drive Grotthuss Proton Conduction in Structured Electrolytes Based on Deep Eutectic Solvents

ABSTRACT Structured electrolytes based on deep eutectic solvents (DESs) face electrochemical limitations of vehicular diffusion due to high viscosities often leading to low conductivities. Here, we demonstrate that the inverse relationship between viscosity and conductivity in DE...

Solvation structure and dynamics of choline chloride-based deep eutectic solvents with isomeric butanediol hydrogen bond donors

Choline chloride-based deep eutectic solvents (DESs) are being investigated as redox flow battery electrolytes, where solvent viscosity plays a central role in governing ionic mobility, mass transport, and pumping efficiency. In this combined experimental and computational study,...

Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine

Abstract Objective This study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. Study design Secondary data analysis on 179 pregnant women a...

Nipsnap 1 deficiency shifts neuronal and synaptic signaling toward inflammatory pathway and impairs cognitive functions in the aging brain

Mitochondrial quality control is essential for maintaining neuronal function during aging. Nipsnap1 (Nip1), a mitochondrial protein involved in mitophagy, metabolic regulation, and cellular senescence, has emerged as a potential regulator of tissue homeostasis; however, its role...

Childbirth, Sexual Function, and Sexual Distress Among Women: An Updated Review

Abstract Purpose of review The aim of this review was to examine the recent empirical literature on the association between childbirth and postpartum sexual function. Recent findings A total of 72 articles were reviewed. Many studies focused on the role of medical aspects of chil...