Brigham and Women's Hospital

Clinical Validation of a Point-of-Care Whole Blood Coagulometer in Patients on Factor Xa Inhibitors

Currently, no sensitive, widely available, rapid turnaround assays to measure the effect on coagulation of direct oral anticoagulants exist. The point-of-care ClotChek (Perosphere Technologies Inc.) coagulometer was developed to address this unmet need with high sensitivity and p...

The Impact of Psychosocial Factors on Pain and Functional Outcomes After Rotator Cuff Repair: A Systematic Review

Introduction Outcomes after rotator cuff repair are commonly evaluated in terms of structural healing and surgical technique. However, psychological factors may also influence patients’ experience of pain and functional recovery. Increasing attention has therefore been directed t...

Novel Autoantibodies in Rheumatoid Arthritis: Translational Prospects from Seronegative Breakthrough to Precision Diagnosis and Treatment

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic, erosive synovitis. While significant progress and breakthroughs have been made in disease diagnosis through basic research and clinical practice, approximately 30%–40% of seronegative RA patients still e...

Activation of the angiotensin II type I receptor by a nonpeptide agonist

The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the most successful pharmacological targets for the treatment of hypertension. Within the angiotensin receptor pharmacological landscape, a...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...

Safety and Efficacy of Colchicine for the Treatment of Pericarditis in Patients with Chronic Kidney Disease

This retrospective multicenter cohort study compared the safety and efficacy of low- versus high-dose colchicine in adult patients with chronic kidney disease (CKD) treated for pericarditis between August 2015 and August 2024. CKD was identified using ICD codes and confirmed by a...

Inflammatory Breast Cancer-Related Lymphedema

Background: Breast cancer-related lymphedema (BCRL) is a potentially debilitating outcome following breast cancer treatment. Much attention has been given to preventive and curative strategies for BCRL. Patients with inflammatory breast cancer (IBC) are at particularly increased...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

A systematic review of environmental factors in AI-based fall risk prediction models for community-dwelling older adults

Falls commonly occur in home environments, where conditions can increase fall risk. Identification and mitigation of environmental hazards are critical components of fall prevention. However, artificial intelligence (AI)-based fall prediction models have largely focused on indivi...

Clinical-histological and genetic features of rare variants of melanoma.

Melanoma is traditionally classified into a limited number of common clinicopathologic subtypes; however, routine clinical and histopathologic practice reveals a broad spectrum of rare variants and unusual morphologic patterns that pose significant diagnostic and therapeutic chal...

Autoantibody Clusters and SIGLEC1 are Predictive of Systemic Lupus Erythematosus Development

Objectives Up to one-third of patients with suspected SLE progress to definite disease, but reliable predictive markers are lacking. Previously, we developed a Lupus Lymphocyte Activation Score (LLAS) based on key cell subsets (transitional B cells, age-associated B cells, plasma...

Long-term Safety and Efficacy of Dazukibart in Dermatomyositis: Combined Phase 2 Results from Double-blind and Open-Label Extension Studies

Objective To evaluate long-term safety and efficacy of dazukibart, a novel anti-interferon beta monoclonal antibody, in adults with moderate-to-severe dermatomyositis (DM). Methods Participants from two cohorts of DM (skin-predominant, SP and muscle-predominant, MP), completing a...

How well can off-the-shelf LLMs elucidate molecular structures from mass spectra using chain-of-thought reasoning?

Mass spectrometry (MS) is a powerful analytical technique for identifying small molecules, yet determining complete molecular structures directly from tandem mass spectra (MS/MS) remains a long-standing challenge due to complex fragmentation patterns and the vast diversity of che...