Brigham and Women's Hospital

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

Comprehensive Analysis of US Health Care Spending on Injuries

BACKGROUND: Traumatic injury affects every age group, payer, and care setting in the United States, yet how injury-related spending distributes across these dimensions has not been comprehensively quantified. OBJECTIVE: To estimate US health care spending on injuries in 2022 by m...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Money, Meals, and Marketing in Medicine: A 13‐Year Follow‐Up Survey of Physicians

Pharmaceutical company marketing to physicians is known to impact prescribing patterns. In 2011, we surveyed medical students and residents about physician/industry relationships. In 2024, we resurveyed the same participants to study changes in their behaviors over time and their...

Characteristics of Patients Undergoing Revision Thumb CMC Arthroplasty

Purpose The purpose of this study was to describe the demographic and operative characteristics of patients undergoing revision thumb carpometacarpal (CMC) arthroplasty and to characterize technique transitions from primary to revision surgery. Methods A retrospective review of r...

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery after Laparoscopic or Arthroscopic Procedures

Suzetrigine, a non-opioid voltage-gated sodium channel 1.8 (Na V 1.8) pain signal inhibitor with no addiction potential, is approved in the USA for moderate-to-severe acute pain. In this phase 4, single-arm study, suzetrigine (100 mg preoperatively, then 50 mg every 12 h) was adm...

Evaluation of the Relative Citation Ratio Versus the H-Index as Measures of Citation-Based Scholarly Influence in Academic Neurosurgery

BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...

The Impact of Psychosocial Factors on Pain and Functional Outcomes After Rotator Cuff Repair: A Systematic Review

Introduction Outcomes after rotator cuff repair are commonly evaluated in terms of structural healing and surgical technique. However, psychological factors may also influence patients’ experience of pain and functional recovery. Increasing attention has therefore been directed t...

Clinical Validation of a Point-of-Care Whole Blood Coagulometer in Patients on Factor Xa Inhibitors

Currently, no sensitive, widely available, rapid turnaround assays to measure the effect on coagulation of direct oral anticoagulants exist. The point-of-care ClotChek (Perosphere Technologies Inc.) coagulometer was developed to address this unmet need with high sensitivity and p...

Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy

Single-cell–level resolution tumor therapy represents an advanced strategy against glioblastoma but lacks suitable theranostic agents. Here, we developed a spatiotemporal-switchable, two-dimensional (2D), bismuthene-based second near-infrared window (NIR-II) nanozyme. In this pla...

Novel Autoantibodies in Rheumatoid Arthritis: Translational Prospects from Seronegative Breakthrough to Precision Diagnosis and Treatment

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic, erosive synovitis. While significant progress and breakthroughs have been made in disease diagnosis through basic research and clinical practice, approximately 30%–40% of seronegative RA patients still e...

Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study

Abstract Objective To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. Design Population based cohort study, using a design, data, and analytical ap...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...

Safety and Efficacy of Colchicine for the Treatment of Pericarditis in Patients with Chronic Kidney Disease

This retrospective multicenter cohort study compared the safety and efficacy of low- versus high-dose colchicine in adult patients with chronic kidney disease (CKD) treated for pericarditis between August 2015 and August 2024. CKD was identified using ICD codes and confirmed by a...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

Activation of the angiotensin II type I receptor by a nonpeptide agonist

The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the most successful pharmacological targets for the treatment of hypertension. Within the angiotensin receptor pharmacological landscape, a...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...