Asan Medical Center

Distinct immune inflammatory markers and proteomic signatures underlying psoriasis with pruritus

Pruritus is a common and burdensome symptom in patients with psoriasis, yet its underlying systemic mechanisms are not sufficiently defined. To characterize systemic immune-inflammatory profiles and serum proteomic differences associated with pruritus in patients with psoriasis a...

The double barrier: coronavirus disease 2019 and cervical cancer screening disparities among women with disabilities in South Korea: a nationwide cohort study

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems, potentially exacerbating pre-existing health disparities. Women with disabilities face structural barriers to healthcare that may be intensified during public health crises....

Cumulative Local and Metachronous Recurrence Rates in Patients with Ulcerative Colitis-Associated Neoplasia after Endoscopic Submucosal Dissection

Background/Aims: Endoscopic submucosal dissection (ESD) has emerged as a curative alternative for ulcerative colitis-associated neoplasia (UCAN), particularly when endoscopic mucosal resection is not feasible for complete resection. This study aimed to evaluate cumulative inciden...

Paradoxical prognosis of extracellular vesicle-derived miR-4435 expression in advanced colorectal cancer

Abstract Extracellular vesicle (EV)-derived microRNAs are promising non-invasive biomarkers for colorectal cancer (CRC), but their stage-specific prognostic significance remains unclear. We evaluated circulating EV-derived miR-4435 and its target TIMP3 in a retrospective cohort o...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Comparison of Uncovered and Covered Biliary SEMS for the Salvage of Obstructed SEMS: A Multicenter Retrospective Propensity Score–Weighted Study

BACKGROUND AND AIMS: Recurrent biliary obstruction (RBO) is common after uncovered self-expandable metal stent (UCSEMS) placement in unresectable distal malignant biliary obstruction. We compared stent patency, clinical outcomes, and RBO patterns between fully covered (FCSEMSs) a...

Estimating Parkinson’s disease finger tapping severity from RGB videos using a temporal–statistical–spectral feature fusion framework

Parkinson’s disease (PD) is characterized by progressive motor impairment, and finger tapping is widely used in the MDS-UPDRS (Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale) to assess bradykinesia. However, clinical scoring is limite...

Arthroscopic partial meniscectomy should be performed carefully for medial meniscus tear with the anteromedial meniscofemoral ligament

The clinical relevance of the anteromedial meniscofemoral ligament (AMMFL) in medial meniscus (MM) tears remains unclear. This study investigated whether arthroscopic partial meniscectomy (APM) for MM tears with AMMFL is associated with joint degeneration. Among 2568 patients who...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Vascular Imaging Features and Time-Specific Recurrence Risk After Craniocervical Artery Dissection

Background and ObjectivesCraniocervical artery dissection (CCAD) is a major cause of stroke in young adults, yet its recurrence risk remains poorly defined because of delayed enrollment in prior research. We aimed to determine the temporal distribution of recurrent ischemic strok...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Residential indoor air monitoring to assess long-term exposure to air pollution in susceptible populations for epidemiology: overview and early findings

While there has been accumulating evidence of the association between long-term exposure to air pollution and various health endpoints, most epidemiological studies relied on ambient air pollution which showed substantial deviation from indoor. This difference could lead to biase...

Chronic Subdural Hematoma in the Super-Aged Society: From a Traumatic Curiosity to a Self-Perpetuating Vascular-Inflammatory Disease

Chronic subdural hematoma (cSDH) was traditionally regarded as a simple mechanical consequence of head trauma, treated by burr-hole drainage alone. Recent ultrastructural, histopathological, and clinical evidence has reframed cSDH as a chronic, self-perpetuating disease driven by...

Diagnostic Utility of the Albumin-to-Globulin Ratio for Kawasaki Disease in Children Presenting to the Emergency Department

OBJECTIVES: Early diagnosis of Kawasaki disease (KD) is essential to prevent coronary artery complications but may be challenging in the emergency department (ED), particularly in patients who do not meet the complete clinical criteria. Although hypoalbuminemia is commonly used a...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Depression as a Risk of Lung Cancer in Women: a Nationwide Cohort Study

BACKGROUND: Lung cancer is a leading contributor to global cancer incidence and mortality. While depression has been linked to adverse health behaviors, particularly tobacco smoking, that may elevate cancer risk, the direct relationship between depression and lung cancer remains...

Remimazolam Versus Propofol for Anesthesia with I-Gel Airway Management During Coil Embolization of Unruptured Intracranial Aneurysms: A Randomized Controlled Trial

Background: Maintaining hemodynamic stability is crucial during coil embolization of unruptured intracranial aneurysms. Remimazolam has been suggested to exert less cardiovascular depression than propofol and may therefore provide more stable hemodynamic conditions. This study co...

Outcomes of Asian and Caucasian patients with type A aortic intramural haematoma: a multicentre registry analysis

Background Outcomes of aortic intramural haematoma (IMH) have shown disparities between Asian and Caucasian patients. We evaluated the heterogeneity of treatment effects in Asian and Caucasian patients with type A IMH. Methods This multicentre registry included individual patient...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...