Institution
Asan Medical Center
Recent research
- Health & MedicineOpen access
Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...
- Health & MedicineOpen access
Background/Aims: Although the use of device-assisted enteroscopy (DAE) has increased, few large-scale studies have examined long-term outcomes focused on small bowel (SB) bleeding. We analyzed National Health Insurance Service data to evaluate the clinical utility of DAE in patie...
- Health & MedicineOpen access
PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...
- Health & MedicineOpen access
Background and Objectives: Remimazolam is an ultra-short-acting benzodiazepine suitable for continuous infusion; however, evidence regarding its maintenance infusion rate for moderate sedation during spinal anesthesia across age strata is limited. We aimed to estimate and compare...
- Health & Medicine
BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...
- BiologyOpen access
Artemisinin and its derivatives possess anti-malarial as well as anti-cancer properties against various malignancies. However, their clinical application as anti-cancer agents is limited by several factors, most notably a lack of tumor selectivity. To address this limitation, we...
- Health & MedicineOpen access
Individual hemodynamic responses to tracheal intubation vary considerably. We examined whether preoperative pulse rate variability (PRV), a photoplethysmography-derived surrogate of heart rate variability, is associated with this response. In this retrospective secondary analysis...
- Health & Medicine
BACKGROUND AND OBJECTIVES: Stereotactic targeting of the ventral intermediate nucleus of the thalamus (Vim) in tremor surgery traditionally relies on indirect, atlas-based coordinates, whereas direct visualization of the Vim using advanced MRI sequences has the potential to impro...
- Health & MedicineOpen access
The 2025 Korean pediatric advanced life support guideline update introduces clinically important revisions emphasizing airway strategy, physiologic resuscitation targets, post-cardiac arrest hemodynamics, neuroprotection, and extracorporeal support. In out-of-hospital pediatric c...
- Health & MedicineOpen access
The 2025 Korean Guidelines for Cardiopulmonary Resuscitation provide updated, evidence-based recommendations to optimize the transition from intrauterine to extrauterine life. While approximately 85% of term newborns initiate spontaneous breathing independently, timely interventi...
- Health & MedicineOpen access
Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific
Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring coordinated multidisciplinary care. This study aimed to develop consensus recommendations for NF1 management in the Asia-Pacific region. A modified Delphi process involving two survey rounds and a virtual...
- Health & MedicineOpen access
Pediatric cardiac arrest primarily arises from asphyxia in infants and trauma in older children, contrasting with adult etiologies dominated by cardiac events. This underscores prevention as the cornerstone of pediatric basic life support, through injury mitigation like child res...
- Health & MedicineOpen access
Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...
- Health & MedicineOpen access
PurposeAlthough chemotherapy can disrupt homeostasis of gut microbiota, the role of chemotherapy affecting in gut microbiota of pancreatic ductal adenocarcinoma (PDAC) is unclear. Materials and MethodsWe evaluated whether chemotherapy could alter the integrity of gut microbiota o...
- Health & Medicine
Fasting Duration and Differences Across Routine Laboratory Tests
Importance Fasting before blood collection is widely practiced to reduce preanalytical variability, yet whether fasting-related differences are clinically meaningful across a broad panel of routine analytes has not been systematically evaluated using clinical data. Objective To e...
- Health & MedicineOpen access
Purpose This study aimed to evaluate the efficacy and safety of low-concentration, nanoparticle-based cyclosporine eye drops (SCAI-001 0.01% and SCAI-001 0.02%) compared to those of the conventional Restasis ® (cyclosporine 0.05%) emulsion for dry eye disease (DED). Methods In th...
- Health & MedicineOpen access
Anaphylaxis with Paradoxical Hypertension During Platelet Transfusion: A Case Report
with epinephrine [2].Nevertheless, atypical presentations of anaphylaxis without hypotension have been reported, including cases with normal or elevated blood pressure [3,4].Such presentations may delay recognition or lead to misdiagnosis, particularly in transfusion settings whe...
- Health & MedicineOpen access
ABSTRACT Background and Aim Although clarithromycin resistance is a major cause of empirical triple therapy failure for Helicobacter pylori eradication, the clinical relevance of amoxicillin susceptibility remains uncertain. We first compared eradication outcomes between empirica...
- Health & MedicineOpen access
Distinct immune inflammatory markers and proteomic signatures underlying psoriasis with pruritus
Pruritus is a common and burdensome symptom in patients with psoriasis, yet its underlying systemic mechanisms are not sufficiently defined. To characterize systemic immune-inflammatory profiles and serum proteomic differences associated with pruritus in patients with psoriasis a...
- Health & MedicineOpen access
Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...