Asan Medical Center

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Paired Whole-Genome Sequencing of Scalp Angiosarcoma and Matched Lung Metastasis Reveals Common Clonal Origin and Lung-Specific Evolution

Background and Clinical Significance: Cutaneous angiosarcoma frequently metastasizes to the lungs, where it may rarely present as diffuse cystic lung disease with recurrent pneumothorax, resulting in substantial diagnostic difficulty. We report a case of pulmonary metastatic cuta...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

GRP78/BiP as a novel midbody component induces mitotic exit failure via PLK1 stabilization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and is associated with a poor prognosis, even when diagnosed in its early stages. Therefore, identifying novel HCC targets for therapeutic drug development is critically needed. Our pr...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Targeting CDK7 to overcome hypomethylating agent resistance in acute myeloid leukemia

Abstract Purpose Hypomethylating agents (HMAs), such as azacitidine and decitabine, are widely used in elderly or medically unfit patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). However, most patients eventually develop primary or acquired resistance...

P1.229. Prognostic Value of Tumor Length in Clinical T1–2N0M0 Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The TNM staging system for esophageal cancer defines the T stage by depth of invasion rather than tumor size. However, prognosis may vary within the same T stage. This study...

Equity in the contemporary oceans governance framework: a stocktake of UNCLOS and its implementing agreements

Abstract Inequity is one of the many challenges ocean governance faces. Equity principles are increasingly receiving attention; for example, the ‘principle of equity and the fair and equitable sharing of benefits’ was included in the Agreement for Biodiversity Beyond National Jur...

Safety and Effectiveness of Intramuscular Dexmedetomidine Versus Per-Rectal Thiopental for Pediatric Brain Computed Tomography Sedation: A Retrospective Cohort Study.

OBJECTIVES: Following per-rectal thiopental (PR-THP) supply discontinuation, a tertiary pediatric emergency department in Korea transitioned to intramuscular dexmedetomidine (IM-DEX) for brain computed tomography (CT) sedation. We evaluated the safety and effectiveness of this pr...

Long-term follow-up results of topical imiquimod for high-grade cervical intraepithelial neoplasia in young women: an original research

<title>Abstract</title> Background As cervical excisional treatment is associated with adverse pregnancy outcomes, imiquimod has been explored in several studies—such as the TOPIC-3—as an alternative but without success. Therefore, we designed a study focusing on patients aged &l...

Nationwide pediatric injury surveillance across two successive system disruptions in South Korea, 2016–2024

Abstract Background Long-term trends in emergency department (ED)-based pediatric injury surveillance during and after the COVID-19 pandemic remain poorly characterized, particularly in settings that experienced additional system-level disruption. In February 2024, South Korea ex...

Polynucleotides Attenuate Atopic Dermatitis-like Inflammatory Signaling in Keratinocytes and Macrophages

Background: Atopic dermatitis (AD) is a persistent and recurring skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and elevated expression of proinflammatory mediators. We investigated the anti-inflammatory potential of polynucleotides (PN), highl...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Long-term treatment with sirolimus for pediatric vascular anomalies

Abstract Background Although sirolimus has emerged as a safe and effective treatment modality for unresectable vascular anomalies, comprehensive long-term follow-up data remain scarce in the current literature. This study aims to evaluate the long-term clinical experience of pedi...

Prenatal PM2.5 exposure drives epigenetic reprogramming of fetal macrophages linked to atopic dermatitis

Abstract Prenatal environmental exposures are increasingly recognized as contributors to atopic dermatitis (AD), yet the underlying mechanisms remain unclear. Fine particulate matter (PM 2.5 ), a complex mixture of airborne pollutants, has been associated with elevated risk of al...

TMEM135 deficiency prevents intestinal lipid accumulation by coordinating lipid uptake and oxidation through ELOVL6-mediated PPARα activation

Abstract Excessive lipid accumulation impairs digestion and gastrointestinal function. Transmembrane protein 135 (TMEM135) is involved in lipid metabolism of various tissues. Here, TMEM135 deficiency increased intestinal lipid absorption through ELOVL6-dependent oleoylethanolamid...

Phenotyping Sepsis at Emergency Department Presentation Using Early Clinical Data: A Multicenter Cohort Study

Background: Sepsis is heterogeneous, and early emergency department (ED) management is constrained by limited information and dynamic clinical trajectories. Methods: Using the nationwide Korean Sepsis Alliance (KSA) registry, we applied k-means clustering to nine routine ED varia...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS)

Abstract Background The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to in...