Amsterdam University Medical Centers

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Heart failure with a preserved ejection fraction: synergy between cardiac and extracardiac mechanisms and effects of novel therapies

Heart failure with preserved ejection fraction (HFpEF) is a systemic disease in which metabolic comorbidities obesity, type 2 diabetes (T2D), and chronic kidney disease (CKD) converge to drive systemic inflammation, endothelial dysfunction, and myocardial fibrosis. Microvascular...

Minimally invasive needle arthroscopy versus conventional arthroscopy for treatment of bacterial knee arthritis: protocol of a pragmatic, multicenter, randomized, controlled, non-inferiority trial (MINA-TRIAL)

Abstract Background Recent innovation offers the possibility for joint drainage under local anaesthesia for the treatment of bacterial arthritis of the native knee, using minimally invasive needle arthroscopy (MINA). Compared with conventional arthroscopy, MINA enables immediate...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

A systematic scoping review identifying effective virtual reality stress tasks inducing physiological reactivity for future wearables validation

Abstract Efficient and ecologically sound validation of wearables remains a major challenge in stress research. Virtual reality (VR) could support this by providing standardized, immersive stress induction, but the field lacks a comprehensive and exhaustive overview of which VR t...

Langerhans cells as targets of rabies virus immune evasion

Rabies virus (RABV) is a neurotropic virus of the genus Lyssavirus that causes a nearly always fatal encephalitis in humans once it reaches the central nervous system. Dog bites are a major transmission route of RABV, and following superficial skin exposure, RABV first encounters...

Impact of neoprene wetsuits on lung volumes and work of breathing: implications for military diver safety and performance

Introduction: Neoprene wetsuits may impose mechanical constraints on the chest wall, potentially altering respiratory function. This study investigated the impact of neoprene wetsuits on lung volumes, airway mechanics, and work of breathing (WOB) in healthy male divers. Methods:...

Identifying methodological guidance used for systematic reviews, clinical practice guidelines, and health technology assessment for rare diseases: a scoping review protocol.

OBJECTIVE: This scoping review will identify methodological guidance relevant to systematic reviews (SRs), clinical practice guidelines (CPGs), and health technology assessments (HTAs) for rare diseases, and examine methodological challenges associated with their development. INT...

Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity

Abstract The global prevalence of overweight and obesity has increased markedly over recent decades. In clinical obesity care, and in the management of other chronic conditions, the role of physical exercise has largely been evaluated in the context of weight loss. Yet, while it...

Effects of exercise on muscle strength and characteristics in rheumatic diseases and sarcopenia: Protocol for the Care for Muscle (C4M) Study

Objective Muscle weakness is prevalent in rheumatoid arthritis (RA), osteoarthritis (OA) and sarcopenia (SARC). Endurance exercises may improve mitochondrial function and oxidative capacity, while strength exercises are thought to stimulate myofibrillar protein synthesis. This st...

Associations between reduction of hypotension and treatment intensity in hypotension prediction index studies

BACKGROUND: The Hypotension Prediction Index (HPI) is developed for proactive prevention of hypotension and existing meta-analyses report reduced hypotension with HPI-guided management in comparison with a strategy based on MAP alerts of 65 mmHg. Still, validation studies suggest...

Early‐stage myocardial changes are not aggravated by Western diet or ageing in Mybpc3 c.2373insG heterozygous mice

Abstract Hypertrophic cardiomyopathy (HCM) caused by heterozygous pathogenic gene variants is characterized by highly variable disease phenotypes. Ageing and systemic metabolic disruption are thought to act as additional ‘second hits’ that modulate this genotype–phenotype relatio...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Results from the Pan-European CIEMAR study: Local Tumour Control After Microwave Ablation of Colorectal Liver Metastases and Exploratory Associations with Ablation Margins and Confirmation Software

Abstract Purpose The CIRSE Emprint Microwave Ablation (MWA) Registry (CIEMAR) was designed to evaluate real-world effectiveness of MWA for colorectal liver metastases (CRLM). This analysis reports on local tumour control and includes post-hoc analyses of ablation margin size and...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

The Reproducibility Promotion Plan for Funders–a co-created set of recommendations to foster reproducible research practices

Abstract Reproducibility is a critical component of research integrity, enhancing the quality, efficiency and trustworthiness of scientific knowledge. Despite increasing attention, reproducibility remains insufficiently prioritized within the scientific agenda. Research funders a...

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

Poor mental health in patients with symptomatic osteochondral lesions of the talus

Aims Osteochondral lesions of the talus (OLT) can cause pain and functional limitations, potentially affecting mental health. This study aimed to compare mental health in patients with OLT to the general Dutch population and individuals with mood or anxiety disorders, and to iden...

Feasibility of radiomics and deep learning methods for prognosis of non–small cell lung cancer using 18F-FDG PET/CT

Accurate prognostication for non-small cell lung cancer (NSCLC) is challenging due to tumor heterogeneity and the limitations of conventional PET biomarkers. This technical feasibility study compared the difference in prognostic performance of radiomics and deep learning (CNN) me...