Amsterdam University Medical Centers

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

Good Quality of Life 3 Decades After Rotationplasty

Background: Long-term quality of life (QoL) after rotationplasty is important because prolonged patient survival has become more common. This study assessed QoL decades after rotationplasty. Methods: This cross-sectional study included surviving patients who had been treated for...

EXPRESS: Bayesian networks to estimate prognosis in vascular cognitive impairment and small vessel disease: integrated analyses of interdependent contributors to multiple outcomes

BACKGROUND: Vascular cognitive impairment (VCI) and small vessel disease (SVD) involve interconnected factors influencing multiple outcomes, also beyond cognitive decline. Bayesian networks (BNs) can help unravel these complex interrelations, which we demonstrate in this proof-of...

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

How to Establish a Reference Interval: A Practical Approach.

BACKGROUND: Establishing accurate reference intervals (RIs) is essential for interpreting clinical chemistry laboratory test results and ensuring clinical relevance. The aim of this review is to provide a practical guide to determine RIs using direct and indirect methods. CONTENT...

Endometrial scratching in patients with unexplained infertility who have a good prognosis for natural conception: a randomized controlled trial (SCRaTCH-OFO).

STUDY QUESTION: Does endometrial scratching improve live birth rates in patients with unexplained infertility who have a good prognosis for natural conception (Hunault score ≥ 30%)? SUMMARY ANSWER: The cumulative live birth rate per intention-to-treat (ITT) was 64% and 57% in the...

Infections in MonumenTAL-1: a plain language summary of talquetamab treatment for relapsed/refractory multiple myeloma

Plain Language SummaryWhat is this summary about?This summary describes infection and immune cell data of participants receiving talquetamab for relapsed/refractory multiple myeloma (RRMM) in the MonumenTAL-1 study.What were the results?Almost 60% of participants receiving talque...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Development and evaluation of a quality assessment tool for equality, diversity, and inclusion (QUALITY-EDI) within healthcare research

Implementing equality, diversity, and inclusion (EDI) in healthcare research is critical to ensuring findings are translatable and provide the greatest benefit to patients who need it most. A quality assessment scoring tool (QUALITY-EDI) was developed to evaluate the conduct of E...

Metabolic and DNA-based assays provide equally reliable measures of cell viability across experimental conditions

Accurately and reliably assessing cell viability is a fundamental necessity in biomedical research. However, many cytotoxic compounds used in cancer research have both on- and off-target effects on cellular metabolism, which may confound metabolism-based cell viability assessment...

The classification for Adverse events in GastRointEstinal Endoscopy (AGREE): three-year evaluation and additional recommendations

Background In 2021, a novel classification for gastrointestinal endoscopy-related adverse events (AEs) was introduced: the AGREE classification. This classification was developed to minimize subjectivity in AE assessment and facilitate more robust comparisons of endoscopic and su...

The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes

The timing of physical activity and exercise has been suggested to play a role in metabolic health. This narrative review synthesises current evidence on the impact of habitual physical activity and exercise timing on glucose homeostasis and insulin sensitivity, blood lipids and...

Plasma indole-3-propionic acid is a gut-derived metabolite and is associated with type 2 diabetes and cardiometabolic outcomes: Evidence from a human antibiotic intervention

The gut microbiota influences host metabolism through diverse metabolites, many of which have been linked to glucose homeostasis and type 2 diabetes (T2D). Understanding microbial contributions to metabolite biosynthesis is essential for developing dietary and microbiota-targeted...

Development of a checklist of characteristics to help identify predatory journals: a Delphi study

This is a Delphi study that aims to achieve expert consensus on the most important characteristics for identifying predatory journals. The results will be used to develop a checklist that may support researchers, editors, librarians, institutions, and policymakers when assessing...

Molecular imaging tracers targeting c-MET: a systematic review of preclinical evidence and clinical translation

INTRODUCTION: The mesenchymal-epithelial transition factor (c-MET) is an emerging target for molecular imaging owing to its widespread overexpression across multiple cancer types. This systematic review evaluated radioactive and fluorescent c-MET-targeting tracers in preclinical...

Weight management in cardiology practice: challenges and opportunities

Abstract Obesity poses a clear challenge to the cardiovascular landscape. In this viewpoint, we advocate that we need to prepare for the practical implementation of weight management in Dutch cardiology practice by 1) educating ourselves and our peers on obesity and its treatment...

Initial Experience with Pseudomonopolar Local Field Potentials in Deep Brain Stimulation for Parkinson's Disease

BACKGROUND: Local field potentials (LFPs) can assist DBS contact selection in Parkinson's disease (PD). To overcome the spatial uncertainty of bipolar recordings, pseudomonopolar recordings with an onboard algorithm have recently been introduced. OBJECTIVE: To report initial expe...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Discussing menopausal symptoms at work and associations with taboo, symptom severity, and need for recovery after work

Objective: Although the impact of menopausal symptoms at work is increasingly recognized, it remains unclear to what extent and with whom menopausal symptoms that limit work functioning are discussed. We examined this and explored associations with taboo, symptom severity, and ne...