Amsterdam University Medical Centers

New insights into statin-intolerance: biopsychosocial differences, medication beliefs, trust in healthcare and treatment decisions in statin-intolerant versus statin-tolerant patients.

AIMS: This study examined biopsychosocial differences between statin-intolerant and statin-tolerant patients, including their medication beliefs, healthcare trust and influential factors for treatment decisions. METHODS: A cross-sectional survey study was conducted among current...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Redefining liver health: a multidimensional approach to preventing metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...

Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis

Leukemia stem cells (LSC) are thought to be responsible for relapse in patient with acute myeloid leukemia (AML). LSC can be quantified at diagnosis to improve risk stratification, and during follow-up to monitor residual disease. To systematically evaluate the prognostic relevan...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

DAVE: how to use explainable AI to interpret missense variants for genome diagnostics based on functional protein modeling

<ns5:p>Background Diagnostic yield in NGS genome diagnostics is constraint by the high fraction of variants of uncertain significance (VUS), largely due to poor interpretability of missense variation. Current pathogenicity predictors often provide strong performance but lack mech...

Interobserver and intraobserver variability of fetal and maternal Doppler measurements: systematic review and meta‐analysis

ABSTRACT Objectives To evaluate the variability and reproducibility of umbilical artery (UA), fetal middle cerebral artery (MCA) and uterine artery (UtA) Doppler ultrasound measurements in pregnancy. Methods A systematic search of MEDLINE, EMBASE and the Cochrane Library (CENTRAL...

High prevalence of low faecal elastase levels in individuals with type 1 diabetes is associated with diabetes duration but not with marked alterations in food intake or clinical symptoms

Abstract Aims/hypothesis Although exocrine pancreatic insufficiency (EPI) is thought to be common in type 1 diabetes, little is known about the relationship of EPI with type 1 diabetes parameters or food intake and abdominal complaints. Characterising individuals with EPI could h...

Evidence for non-mucinous pulmonary lesions with adenocarcinoma in situ morphology exceeding the current 3 cm WHO threshold

CONTEXT: The World Health Organization (WHO) recognizes adenocarcinoma in situ (AIS) of the lung for tumors up to 3 cm in size. Larger tumors with a lepidic growth pattern are classified as invasive lepidic predominant adenocarcinoma. OBJECTIVE: The aim of this study was to demon...

Measuring healthcare quality in police custody: the development of quality indicators through expert consultations in the Netherlands

Abstract Background Improving the quality of care for people detained in police custody requires careful measurement and monitoring. However, a standardized and endorsed set of quality indicators for healthcare in police custody settings is lacking. This study aimed to develop a...

Elective admissions and treatments in the final three months of life: a nationwide retrospective study of older adults

PURPOSE: Research on potentially inappropriate care at the end of life in older adults rarely distinguishes between acute and elective care. As elective care is plannable, it allows for timely deliberation on its appropriateness. This study aimed to explore elective hospital care...

Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis

PURPOSE: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estimate the proportion of hospitalised patients with microbiolo...

Use of neurolytic nerve blocks and mortality in nonoperative management of hip fracture patients

Aims: Nonoperative management may be suitable for very frail hip fracture patients; in these instances, neurolytic nerve blocks with phenol could act as a long-term analgesic, with potentially fewer disadvantages compared with systemic analgesia. While neurolytic nerve blocks are...