Institution
Academy of Scientific and Innovative Research
Recent research
- BiologyOpen access
Microbial modulation of secondary metabolites biosynthesis in plants
Abstract Plants produce a diverse range of secondary metabolites [SMs] such as alkaloids, terpenoids and phenolics, which play crucial roles in defense, signalling and human health applications like pharmaceuticals and nutraceuticals. Traditionally viewed as autonomous plant bios...
- Health & MedicineOpen access
Crocetin HaltsTumorigenesis in Metastatic BreastCancer via Disrupting CYP2J2/EET Axis
Abstract CYP2J2 catalyzes the conversion of arachidonic acid into epoxyeicosatrienoic acids (EET), which have gained significant attention due to their oncogenic properties. Differential overexpression of CYP2J2 in tumors results in increased EET production. The role of EET in tu...
- Biology
ABSTRACT The fossil record serves as the primary source of information for understanding how biodiversity has changed over deep time, offering unique insights into the dynamics of diversification and extinction and their underlying drivers. Much of the focus has been on global di...
- Materials & Energy
Analytical calculation of field enhancement factor of 2D structure graphene film
Field emitters are one of the promising electron sources for vacuum electronic devices operating in mm-wave and terahertz frequencies, where emission performance is critically governed by the field enhancement factor. While extensive analytical models exist for one-dimensional em...
- Health & Medicine
Abstract Copper-based nanomedicines have broader applications in the biomedical sector because of their unique fundamental properties. Very recently, our group has designed and synthesized new copper nitroprusside analogue nanoparticles (CuNPANP in vitro and in vivo) anticancer t...
- Materials & Energy
Abstract The increasing demand for efficient and sustainable energy storage has accelerated research into supercapacitors (SCs), which provide high power density and a long cycle life. However, their poor performance remains a major drawback. The layered structure and rich redox...
- Materials & Energy
Abstract The morphology of thin-film composite membranes is encoded during interfacial polymerization (IP) by competing monomer transport and reaction kinetics, yet molecular control remains limited due to their intrinsic coupling. Herein, we show that counterions decouple solvat...
- Materials & Energy
In this study, we have established a base‐mediated intramolecular vinylogous Mannich reaction, providing a straightforward approach for constructing structurally diverse dihydrobenzofuran and dihydroindole frameworks, which are commonly found in biologically active compounds. Pre...
- Materials & Energy
Abstract The persistent energy-power density trade-off in supercapacitors necessitates advanced electrode materials with synergistic ion transport and redox capabilities. Herein, we report a sonication-assisted synthesis of Nb2C/NiCo2O4 (NCN) nanocomposites, prepared via selectiv...
- Society & Economics
ABSTRACT Lead‐free, eco‐friendly organic–inorganic manganese halides (OIMnHs) have attracted considerable attention for optoelectronic applications, owing to their outstanding optical properties and facile solution processability. Here, we present a novel zero‐dimensional (0D) OI...
- Materials & Energy
Abstract A simple and convenient approach involving visible-light-induced, TBHP-mediated oxidation of propargyl alcohols to ynone in aqueous media has been developed. This photoinduced protocol was conducted under an aerobic-aqueous medium using Eosin Y as a photosensitizer. A di...
- Materials & Energy
Abstract The rapid and reliable detection of toxic contaminants in food and cosmetic products remains challenging because of complex sample matrices and the need for scalable and high-performance electrode materials. Herein, a nanostructured laser-induced porous graphene (LIG) el...
- BiologyOpen access
Esterases, a class of α/β-hydrolases, are crucial enzymes used for the biotransformation of industrially important biomolecules. Exploring the pond metagenome, a lipolytic clone. (PLR5) was identified that exhibited activity against tributyrin. This clone encodes a unique putativ...
- Climate & EnvironmentOpen access
This study evaluates the hydrochemical characteristics and overall suitability of groundwater in Nalanda district, Southern Bihar, India. Forty-one groundwater samples were collected and analyzed for 14 physio-chemical parameters including pH, EC, TDS, hardness, major ions, fluor...
- Biology
Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...
- Biology
Energetic Determinantsof Expanded PAM Recognitionin Engineered FnCas9
Abstract Expanding protospacer-adjacent motif (PAM) compatibility while preserving specificity remains a central challenge in CRISPR–Cas9 engineering. Francisella novicida Cas9 (FnCas9) exhibits high intrinsic specificity but is constrained by stringent PAM requirements. Here, we...
- Health & Medicine
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women having both gynecological and metabolic comorbidities. PCOS increases the risk of cardiovascular and thromboembolic diseases due to heightened prothrombotic states, suggesting sha...