Aarhus University

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

The $$\ell $$-modular local theta correspondence in type II and partial permutations

Abstract In this paper we compute the multiplicities appearing in the $${\overline{\mathbb {F}}_\ell }$$ F ¯ ℓ -modular theta correspondence in type II over a non-archimedean field $$\textrm{F}$$ F , where $$\ell $$ ℓ is a prime not dividing the residue cardinality of $$\textrm{F...

Atmospheric new particle formation enhanced by tricarboxylic acids

Abstract. Organic molecules contribute significantly to the formation of aerosols in the atmosphere, forming what is known as secondary organic aerosols (SOA). The organic molecules are emitted as volatile organic compounds (VOCs), and undergo a number of reactions in the atmosph...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Integrating a pesticide risk indicator into a multi-criteria assessment tool for comparing crop protection scenarios

CONTEXT Chemical pesticides remain central to agricultural productivity but pose well documented risks to human health and ecosystems. While Integrated Pest Management (IPM) offers a more sustainable alternative, its adoption remains limited, partly due to the complex trade-offs...

Biologic-assisted house dust mite immunotherapy in allergic asthma: could it provide a bridge toward de-escalation?

To the Editor,We read with great interest the three-year randomized study by Bozek and colleagues comparing omalizumab, subcutaneous house dust mite allergen immunotherapy (HDM-SCIT), their combina...

Strained Partnership: Biocompatibility and Transcriptomic Responses of Hydrogenotrophic Methanogens to Methyl Diethanolamine in Bio-integrated Carbon Capture and Utilization

Abstract Biointegrated carbon capture and utilization (BICCU) represents a promising alternative to conventional carbon capture technologies, combining microbial methanogenesis with CO2 capture agents, such as methyl diethanolamine (MDEA), to produce renewable methane from dilute...

Virus-like particle display of the SARS-CoV-2 receptor-binding domain using a modular tag/catcher system enhances immunogenicity of a DNA vaccine in mice

The COVID-19 pandemic highlighted the critical need for adaptable, rapid-response vaccine platforms. While mRNA vaccines enabled fast and scalable development, their stringent cold-chain requirements limited global accessibility. DNA vaccines offer a similarly fast and flexible v...

Changing the mediation of climate change discourses: a multimodal (inter)action analysis of identity production and empowerment

Abstract The aim of this study is to explain how multimodal mediation contributes to ongoing identity production and transformation across interconnected layers of discourse when lay experience and expert knowledge enter in dialogue about climate change. By combining multimodal (...

Modeling Nitrate Leaching from Danish Agricultural Fields Using a Machine Learning Approach

The environmental and economic impacts of nitrate leaching from agricultural soils highlight the need for accurate prediction to support effective nitrogen management. This study evaluated six machine learning (ML) models—Multiple Linear Regression, Elastic Net, K-Nearest Neighbo...

Geometry‐dependent migration dynamics of fibroblasts on ECM protein micropatterns

Abstract Extracellular matrix (ECM) micropatterns provide well‐defined adhesive environments for investigating how geometric confinement influences cell migration. Here, we combined ECM protein micropatterning with quantitative live‐cell microscopy to examine NIH 3T3 fibroblast m...

Collagen remodeling is elevated in fibrotic hypersensitivity pneumonitis and may distinguish it from idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP) are two common causes of pulmonary fibrosis. Unlike IPF, fHP is caused by a persistent immune response to an antigen. Misclassification of fHP and IPF can lead to significant delays in antifibroti...

Robust circular cluster-based statistics for respiration-brain coupling

The rapidly developing research field of brain-body neuroscience faces methodological challenges, as analysts continue to develop new analysis strategies for robust statistics in the absence of established best practices. This quest for robust statistics is further complicated by...

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Abstract Recent genetic studies have identified defects in the PIWI-interacting RNA (piRNA) pathway to cause nonobstructive azoospermia. However, limited knowledge of piRNA function in human spermatogenesis makes it difficult to quantify the number of cases affected. Central to t...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

Food Security Versus Environmental Health: The Nitrogen Dilemma

ABSTRACT Nitrogen is an essential element for plant growth and, consequently, crop production. However, the cycling of nitrogen in the environment can have negative effects. Here, we review the historical development of scientific and public awareness of these effects and the inf...

Multi-layer Cis -molQTLs Reveal Regulatory Architecture and Enhance Heritability Explanation for Complex Traits in Cattle

Abstract Genome-wide association study (GWAS) analyses have identified numerous loci associated with economic traits in cattle. Many of these loci reside in noncoding regions, and the regulatory mechanisms through which they influence complex traits remain poorly understood. Here...

Transition without transformation: net-zero industrial policy, green path diversification and creation

The development of new pathways for industrial decarbonisation is a formidable task demanding highly coordinated action. While industrial clusters are potentially key sites for low-carbon transitions, embedded regional structures if not fully understood may constrain green transf...

AI4TEN: Fine-Tuning Pre-Trained Audio Transformers (BEATs, AST) for Cross-Dataset Acoustic Vehicle Classification with Domain Adaptation

Acoustic vehicle classification from roadside microphones supports source-specific traffic noise monitoring, but classifiers trained on one dataset generalize poorly to recordings from different environments. This study compares pre-trained audio transformers (BEATs, AST) against...

Lower methane emissions from full-scale stockpiles of the solid fraction of separated digested slurry with biochar amendment

Field application of biochar can be challenging due to loss through dust release and uneven spreading, and incorporation of biochar into organic fertilisers has been proposed as a practical application strategy. If biochar is added to the solid fraction prior to field application...