Research works

Geropsychosis: A Biophysical Framework for Understanding Psychiatric Symptoms as Accelerated Aging Pathologies

The theory of geropsychosis reconceptualizes anxiety, mood, psychotic, and neurocognitive disorders as primarily emerging from the universal accumulation of metals, advanced glycation end products (AGEs), advanced lipoxidation end products (ALEs), and their hybrid complexes among...

If a machine did it, it is probably transcendental (even p-adically)

Abstract Continued fraction expansions provide a well-established bridge between algebraic properties of numbers and combinatorics on words. In this article, we investigate the algebraicity of p -adic numbers whose continued fractions arise from certain classes of words which gen...

BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity

The US Food and Drug Administration (FDA) launched Project Optimus and issued guidance to reform dose-finding and selection trials, shifting the paradigm from identifying the maximum tolerated dose (MTD) to determining the optimal biological dose (OBD), which optimizes the risk a...

Zippers and Twisters: Planes of Satellite Galaxies Emerge from Whirling and Shocking Gas Streams in the Cosmic Web

Abstract We investigate dwarf satellite systems around massive centrals analogs (Milky Way to Centaurus A) in the NewHorizon simulation. Using simple estimators limiting overdetection, we identify planes of satellites comparable to observations in 30%–70% of cases. The full sampl...

BenthiCat: An opti-acoustic dataset for advancing benthic classification and habitat mapping

Abstract. Benthic habitat mapping is fundamental for understanding marine ecosystems, guiding conservation efforts, and supporting sustainable resource management. Yet, the scarcity of large, annotated datasets limits the development and benchmarking of machine learning models in...

Polynomial Prethermal Lifetimes in Non Smoothly Driven Quantum Systems

Abstract We study the dynamics of a quantum many-body lattice system with a local Hamiltonian subjected to a quasi-periodic driving with finite regularity. For sufficiently large driving frequencies, we prove that the system remains in a prethermal state for times growing polynom...

Scintillator-IntegratedMicrochannel Plate PhotomultiplierTubes for Ultrafast Timing over keV–GeV Energy Scales

Abstract Precise measurement of radiation has long played a vital role in a wide range of research and industrial fields, from fundamental physics beyond the Standard Model to medical imaging such as time-of-flight positron emission tomography. Developing radiation detectors that...

Impact of carbon market trading prices on corporate green innovation

<title>Abstract</title> This study investigates the impact of carbon market prices on corporate market competition and green technological innovation in high-carbon industries in China. We develop a game-theoretic model to analyze the effects of carbon emission restrictions on en...

A Computational Framework for the Design and Development of Isoform Selective PI3Kα Inhibitors as Novel Anticancer Agents

Background: Phosphatidylinositol 3-kinase (PI3K) is a promising anticancer drug target, and selective PI3Kα inhibition may provide both efficacy and an improved safety profile. This study aimed to design new potentially selective PI3Kα inhibitors using computer-aided drug design...

‘So many relationships in the room’: Participant perspectives on the affordances and challenges of co‐therapy in psychedelic assisted therapy

OBJECTIVES: Psychedelic-assisted therapy (PAT) frequently utilises a "cotherapy" model, in which two therapists jointly support participants throughout dosing and psychotherapy sessions. While common in clinical trials, participant experiences of cotherapy remain underexplored. T...

Dynamic latent class structural equation modeling: A hands-on tutorial for modeling intensive longitudinal data.

In this tutorial, we provide a hands-on guideline on how to implement complex Dynamic Latent Class Structural Equation Models (DLCSEM) in the Bayesian software JAGS. We provide building blocks starting with simple Confirmatory Factor and Time Series analysis, and then extend thes...

Jaguar Conservation Units as an Effective Tool in a Payment for Ecosystem Services Scheme for an Apex Predator

ABSTRACT In this paper, we propose an operational framework for Jaguar Conservation Units (JCUs), emphasizing the role of private rural properties in conserving jaguar populations in Brazil while mitigating human–jaguar conflicts and supporting the implementation of payments for...

Exploring Fitness to Participate in Court Proceedings Among Defendants with Fetal Alcohol Spectrum Disorder: A Systematic Scoping Review

<title>Abstract</title> Fetal Alcohol Spectrum Disorder (FASD) is a lifelong neurodevelopmental condition resulting from prenatal alcohol exposure, affecting both cognitive and behavioural functioning. Within the legal system, determining whether an individual can effectively par...

High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density

Abstract Background Flickering visual stimulation can evoke neural oscillations, which can influence ongoing brain activity. Electrophysiological recordings of neural oscillations in the ripple band (80–180 Hz) show that these high-frequency oscillations occur in the neocortex an...

Simulation through CFD of different flow field designs for enhancing proton exchange membrane fuel cell performance

<title>Abstract</title> The performance of Proton exchange membrane fuel cell, a promising energy conversion technology, is closely tied to the design of their flow fields. The Fuel cell architecture plays a critical role in distributing reactant gases, managing water, and dissip...

Who You Meet Matters: International Evidence on Economic Connectedness and Social Mobility

Abstract We construct the first internationally comparable measure of offline economic connectedness (EC), extending the online framework of Chetty et al. to a cross-country setting. We conceptualize EC as access to individuals in high-status occupations and measure it as the pro...

Inclusion Without Representation: Academics’ Perspectives on the Impact of Ethnic-Tribal Identity on Their Professional Development

Ethnic-tribal identity remains a profoundly influential yet underexplored factor shaping the professional development of academics in Cameroonian higher education institutions (HEIs). This study examines how ethnic and tribal identities affect academics' sense of inclusion, acces...

Modified Mitchell-Banks technique in pediatric inguinal hernia repair: a personalized surgical approach

<title>Abstract</title> The authors have requested that this preprint be removed from Research Square.

Application of 80 kVp combined with deep learning reconstruction algorithm in overweight patients coronary CT angiography: reduced radiation dose and contrast agent dose

<title>Abstract</title> Background: Coronary CT angiography (CCTA) has become a key imaging technique for clinical screening of coronary artery disease (CAD). Overweight patients have a higher prevalence of CAD, however, they face increased risks of radiation exposure and contras...

Crossing effects in the tactile temporal order judgment task: a meta-analysis

Abstract The tactile temporal order judgment (TOJ) task is widely used in multisensory neuroscience. Participants judge which of two tactile stimuli, one on each hand, came first. A key finding is that TOJ performance declines when the arms are crossed, likely due to interactions...