Research works

Disentangling the Hemodynamic Effects of A-Wave Loss and Cardiac Output Reduction in Atrial Fibrillation

PURPOSE: Atrial fibrillation (AF) increases thromboembolic risk, yet the relative hemodynamic contributions of A-wave loss, cardiac output (CO) reduction, and patient-specific atrial geometry remain incompletely understood. This study aimed to isolate the hemodynamic consequences...

Burkholderia lata BL02 Galactolipase as an Important Biocatalyst for Plant Biomass Deconstruction and Sugar Ester Synthesis

The transition toward sustainable biorefinery processes requires efficient strategies for lignocellulosic biomass deconstruction and valorization. In this study, an integrated enzymatic system combining fungal holocellulases and laccases with a bacterial galactolipase was develop...

Revisiting aCommon Cobalt Chloride Equilibrium Experimentwith Generative Artificial Intelligence

Abstract We have developed and implemented a first-year undergraduate laboratory experiment at St. Bonaventure University that augments a well-established thermodynamics lab on the spectrophotometric determination of the equilibrium of cobalt(II) chloride hexahydrate with generat...

Genome-Wide Association Study and Identification of Core Candidate Genes for Shoot and Root Length in Wheat During Germination

To address the core breeding demand for greater seedling vigor in bread wheat (Triticum aestivum L.) varieties adapted to the uniform sowing system in China’s Huang-Huai Wheat Region, we aimed to dissect the genetic architecture and identify core candidate genes for shoot length...

Comparative predictive performance of insulin resistance surrogates (TyG and TyG-BMI) and lipid indices for cardiometabolic risk in prehypertensive adults

Abstract Background Prehypertension is the initial stage of the risk pathway of CVD, which commonly associates with hidden metabolic derangements such as insulin resistance and dyslipidemia. In the clinical setting, convenient, inexpensive predictors for early screening are requi...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Carbon Dots as ElectrostaticallyDriven Base-SelectiveChemical Compilers for Programmable Nucleic Acid Condensation

Abstract Cells execute complex biological functions through programmed biomolecular condensation, yet a general and programmable strategy for nucleic acid condensation in vitro remains challenging. Here, we demonstrate that carbon dots (CDs) function as an electrostatic-driven ve...

Brains, Networks and Dynamics

Abstract This paper argues that when brain networks figure in explanations of cognition and behavior they often do so in conjunction with independent dynamical assumptions about signal transmission in the brain. In such cases explanation does not depend on network structure alone...

Genomic Characterization of Colistin and Fluoroquinolone Resistance in Multidrug-Resistant Escherichia coli from Diseased Food-Producing Animals in Taiwan

Background: The global spread of antimicrobial resistance in Escherichia coli (E. coli) from food-producing animals is a critical concern within the One Health framework, particularly because of the potential transmission of clinically relevant resistance determinants across the...

Automated Extraction of Long-Term Cyanobacteria Blooming Series from Landsat Imagery Using Deep Learning

Cyanobacterial harmful algal blooms (CyanoHABs) pose serious threats to inland water ecology and environmental security. Despite advances, accurately capturing their long-term dynamics for effective governance remains challenging due to limited datasets and segmentation model acc...

Rational drug design for Alzheimer’s disease: from approved therapies to next-generation clinical candidates and AI-guided innovation

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multifactorial pathology, including amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation, and synaptic dysfunction. Despite extensive research, currently app...

LaMn1−xNixO3 Perovskite Deposited on γ-Al2O3 Spheres as Catalyst for Dry Reforming of Methane

Dry reforming of methane (DRM) represents a promising route for the valorization of CO2 captured from industrial emissions through high-temperature catalytic conversion. In this work, a LaMn1−xNixO3 perovskite catalyst (x = 0.25, 6 wt% Ni) was synthesized as a powder by solution...

End-to-end deep learning-based determination of programmable shunt valve settings from standard two-view skull radiographs

Accurate identification of programmable shunt valve settings is crucial for managing patients with hydrocephalus, as unintended setting changes can lead to overdrainage or underdrainage of cerebrospinal fluid (CSF). Existing artificial intelligence (AI) models primarily focus on...

Running Performance Decline in IRONMAN-Distance Triathlon: A Scoping Review of Existing Evidence and Research Gaps

In an IRONMAN-distance triathlon, run performance is a particularly strong correlate of overall race outcome, alongside cycling. Although individual research areas such as pacing, performance prediction, and laboratory physiology have been reviewed separately, they have not been...

Economic Hardship and Mental and Physical Health in Social Work Students: Food, Housing, and Student Loan Burden

Economic hardship is prevalent among college students and poses significant risks to health and academic success. This cross-sectional study examined associations between food insecurity, housing insecurity, and educational loan reliance and two health outcomes—depressive symptom...

“We Were in Solidarity with Each Other”: Oral Histories on Coming Out During the AIDS Crisis in Canada

This paper explores identifying, "coming out" and "coming in" as Two Spirit, lesbian, gay, bisexual, trans, and/or queer (2SLGBTQ+) during the AIDS crisis in Canada (1981-1997). We conducted 30 oral history interviews about this unique historical moment between 2022 and 2025 with...

Associations Between Sleep-Related Characteristics and Mind Wandering in Adults with ADHD: A Cross-Sectional Study with a Control Group

Excessive mind wandering is increasingly recognized as a clinically relevant cognitive feature of adult attention-deficit/hyperactivity disorder (ADHD), yet its relationship with sleep-related characteristics remains insufficiently understood. This cross-sectional study with a co...

MSSiS 2026: Report on the EighthWorkshop on Modeling and Simulation of Software-Intensive Systems

In this paper, we report on the outcomes of the Eighth Workshop on Modeling and Simulation of Software-Intensive Systems (MSSiS 2026), held in conjunction with the 48th International Conference on Software Engineering (ICSE 2026), in Rio de Janeiro, Brazil, on April 12th 2026. Th...

Curbing corporate greenwashing with transparency: the governance role of open government data in China

In the digital economy era, open government data (OGD) has become an important institutional arrangement for improving environmental governance and promoting sustainable corporate development. By increasing the transparency and accessibility of public information, OGD may reduce...

Engineered DynamicCo2+ Sites Resolve theComplete Reaction Network for C(sp3)–H Oxidation

Abstract The dynamic evolution of active sites under operating conditions fundamentally dictates catalytic performance, yet state-of-the-art studies remain confined to passive observation, i.e., they are unable to intervene in detrimental dynamics or translate beneficial ones int...