Research works

Building a genomics-capable cancer workforce: a competency-based framework for education and training in precision oncology

Background The Lancet Oncology Commission on cancer genomics and precision oncology identified workforce capability, education, and training as major constraints to equitable implementation. As genomic and multi-omic technologies become integrated into cancer care, structured app...

Existence, Uniqueness, and Long-Time Asymptotic Behavior of Regular Solutions in Multidimensional Thermoelasticity

Abstract. We study a simplified nonlinear thermoelasticity model on two- and three-dimensional tori. A novel functional involving the Fisher information associated with temperature is introduced, extending the previous one-dimensional approach from the first two authors [ SIAM J....

Knowledge is power: the importance of subjective knowledgeability for supporting technology adoption in the Australian grain industry

Agriculture 4.0 technologies such as automated machinery, precision farming, and data-driven decision-making can today help farmers manage the challenges of economic instability and climate adaptation. Yet uptake of on-farm technology is often variable, with reported barriers rel...

Ambidextrous leadership and green attitude foster organizational citizenship behavior for the environment through organizational commitment

This study investigates the determinants of Organizational citizenship behavior for the environment (OCBE) in the retail sector, focusing on minimarkets in an emerging-economy context where empirical evidence remains scarce. It integrates employees’ green attitude and ambidextrou...

Dental pulp stones as an independent predictor for extracranial carotid artery calcification: a cross-sectional cone-beam computed tomography analysis

Vascular calcification is a key indicator of cardiovascular risk, and dental imaging allows its visualization. Dental pulp calcifications (pulp stones) have been suggested as markers of systemic mineralization. This study aimed to assess the association between pulp stones and ex...

Latanoprost Acid–Brimonidine, a New Amide Prodrug for Glaucoma Management Based on the Concept of Sustained Release

Glaucoma is an ocular disease caused by the improper management of elevated intraocular pressure (IOP). IOP-lowering via topical administration is the first choice to prevent further progression. However, patients may forget to administer their medication, compromising IOP contro...

The role of C-reactive protein to lymphocyte ratio and sleep duration in heart failure: exploring the mechanistic interplay and clinical implications

Heart failure (HF) is a progressive disease with complex pathogenesis involving inflammation, immune dysfunction, and metabolic abnormalities. Although C-reactive protein (CRP) is an established HF marker, the CRP-to-lymphocyte ratio (CLR) integrates inflammatory and immune respo...

Unraveling TB Dynamics in Nepal: Navigating Progress, Challenges, and Initiatives

Background: To assess the progress made in TB control, identify persistent challenges hindering effective TB control efforts, and identify the initiatives and recommendations to achieve End TB Strategy. Design/Methods: The study employed a multi-phase approach, combining quantita...

The Effects of Expressive Arts Therapy on Emotion Regulation and Aggression in Violent Offenders: A Randomized Controlled Trial

Violent crime is a widely recognized public health concern. According to emotion regulation theory, aggressive behavior in violent offenders is linked to maladaptive emotion regulation strategies. However, few studies have explored interventions targeting emotional factors to red...

BoDV-1 Infection Is Associated with Altered Prion Protein Glycoform Maturation and Reduced ETS1-MGAT5/GnTV Pathway Activity in Rat C6 Astroglial Cells

Borna disease virus 1 (BoDV-1) is a noncytolytic, neurotrophic virus that causes neurological disorders, where astrocytes contribute to neuropathology. Cellular prion protein (PrPC) is involved in pro-survival signaling and antioxidative defense. Using rat astroglial C6 cells as...

Influence of Composite Mineral Admixtures and Expansive Agent on the Mechanical Properties, Durability and Microstructure of Cementitious Materials

To improve volume stability and durability of cementitious materials, a composite mineral admixture including ground granulated blast furnace slag, fly ash and silica fume was incorporated at a fixed 12% replacement ratio together with varying dosages of an expansive agent (EA)....

Time-resolved imaging of antiferromagnetic skyrmion interactions

Abstract Quantifying particle interactions is central to understanding and controlling collective dynamics in particle-based devices such as those comprising skyrmion ensembles. Here we directly visualize, in real time, the nanosecond current-driven dynamics of an antiferromagnet...

The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial

Background: Prostaglandin E2 (PGE2) suppresses perinatal breathing. Reducing antenatal PGE2 concentrations with paracetamol could stimulate spontaneous breathing in premature infants at birth. We aimed to assess feasibility and potential effects of antenatal paracetamol. Methods:...

Distinct learner profiles of attitudes toward biostatistics in medical education: a latent profile analysis

Biostatistics is essential for interpreting evidence and clinical decision-making, yet medical learners may value it while experiencing anxiety, low enjoyment, and perceived difficulty. Average scores may fail to capture distinct attitude patterns. This study aimed to identify la...

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice

Sarcopenia is an age-related pathological syndrome characterized by progressive and generalized loss of skeletal muscle mass and function, with muscle atrophy representing its cardinal pathological hallmark. Ferroptosis, an iron-dependent regulated cell death, has been implicated...

Coppiced sweet chestnut in the construction of imperfect gridshells from asymptotic curves

In recent years, bending-active gridshells with asymptotic geometry have been successfully constructed at the architectural scale. These have typically used materials such as steel and machined timber, with thin rectangular profiles and predictable characteristics. This paper inv...

Trustworthy Gait Analysis for Computer-Aided Diagnosis in Parkinson’s Disease and Knee Osteoarthritis: A Targeted Narrative Review of Algorithms and Clinical Validation

Gait analysis is increasingly used as a dynamic functional biomarker for computer-aided diagnosis (CADx), although strong internal performance alone does not establish clinical utility. This targeted narrative review examines Parkinson’s disease (PD) and knee osteoarthritis (KOA)...

Online Parameter-Reconfigured Model Predictive Control for Integrated Trajectory Tracking of Distributed Four-Wheel Steering Vehicles

To overcome the limitations of conventional model predictive control (MPC) for trajectory tracking of distributed-drive four-wheel-steering (4WS) vehicles, particularly its fixed weighting matrices and prediction and control horizons, this study investigates the integrated trajec...

TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis

TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturation. In this study, we explored the role...

Managing Disease, Daily Life, and Biography

Physical activity is widely recognized for its beneficial effects on people living with epilepsy, including those with severe forms. However, its practice often remains limited due to perceived risks associated with seizures. In the absence of guaranteed adaptation and safety con...