Research works

Survival, stigma and structural barriers: a qualitative study exploring the oral health experiences of women attending sex work support services in Liverpool

Aims Globally, sex workers experience significant oral health inequalities, including higher levels of dental decay, tooth loss, and trauma. Sex workers face intersecting challenges including homelessness, addiction, and stigma. In the UK, no qualitative research has explored the...

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12

Abstract Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to g...

Lateral sclerosis in amyotrophic lateral sclerosis is an upper motor neuron distal axonopathy (“dying back”): a clinical-neuropathological study

Abstract The hallmark neuropathological feature of upper motor neuron (UMN) degeneration in amyotrophic lateral sclerosis (ALS) is the “sclerosis” of the lateral corticospinal tract (CST)—the major axonal pathway connecting UMNs to lower motor neurons (LMNs). However, few studies...

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding

Abstract Genome size varies more than 10,000-fold across eukaryotes, yet how the mitotic spindle adapts to this range remains unknown. Here we show that metaphase plate width scales with genome size following a power law with an exponent of ~1/3 across eukaryotes. Comparative ana...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Methodology for Modeling and Seismic Analysis of Four Buildings Representative of Bagan’s Monumental Heritage

This paper presents a comprehensive methodology for assessing the seismic vulnerability of four historic monuments in Bagan, including analysis of their architectural and structural characteristics, an evaluation of their behavior in past earthquakes, and finally finite element (...

The Effects of Cerebrovascular Reactivity on the Coupling Between CSF Dynamics and Global Neurovascular Fluctuations in the Alzheimer's Disease Continuum

BACKGROUND: Mounting evidence revealed that the weakened coupling between CSF flow and global brain activity (gBOLD-CSF coupling) is associated with Alzheimer's Disease (AD) pathology and cognitive impairments. However, the mechanisms underlying this weakened coupling remain uncl...

To Walk or Not? A Prospective, Randomised Controlled Trial to Evaluate the Effect of Weightbearing on Patient Outcomes Following First Metatarsophalangeal Joint Fusion

Background: First metatarsophalangeal (MTP) joint arthrodesis is the gold standard surgical treatment of hallux rigidus and severe hallux valgus with osteoarthritis after failed nonoperative management. Despite its common use, postoperative weightbearing protocols vary considerab...

Mechanisms of circularity: How epistemic, financial and material flows construct new waste geographies

Circular Economy (CE) initiatives originate predominantly in the Global North, yet their material, epistemic, and financial effects increasingly manifest in Global South contexts. Using Dutch–Kenya waste relations as a critical case study, this article examines how CE interventio...

Gut microbiota‐derived tryptophan metabolite attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR – SOCS3 – STAT1 axis

Calcium oxalate (CaOx) nephropathy is a highly prevalent urological disease worldwide. Gut microbiota dysbiosis and host metabolic dysregulation are recognized as pivotal drivers in disease pathogenesis, yet the underlying mechanisms remain incompletely understood. In this study,...

Better together: Multi‐Agent system teamwork

Abstract While most present‐day multi‐agent system (MAS) deployments involve teams of agents within a single institution orchestrated by one or a few actors, some researchers are already beginning to appreciate the promise of more complex ecosystems consisting of hybrid human‐age...

Phase control of interfering stimulated Raman pathways in the XUV regime

Abstract Coherent control uses interference between quantum pathways to enhance or suppress transitions to a target quantum state. In stimulated Raman excitation, such control can be achieved through interference between two indistinguishable pathways connecting the same initial...

Modular Cyano-fluoroalkylation of Unactivated Alkenes Enabled by Photoinduced Fe-LMCT Catalysis

Abstract We describe the implementation of an iron catalyzed cyano-fluoroalkylation of unactivated alkenes that leverages inexpensive trifluoroacetic acid (CF3CO2H) and related carboxylic acids (CFnRCO2H) as radical fluoroalkyl sources, together with tosyl cyanide (TsCN) as a low...

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in Brucella

ABSTRACT Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay. The conserved RNA degradosome scaffold, ribonuclease E (RNase E), assembles into phase-separated bacterial ribonucleoprotein bodies (BR-bodies) through its C-terminal...

Advancing chemical reaction prediction in data-scarce drug discovery with active and geometric deep learning

Abstract The success of generative molecular design depends on the synthetic accessibility of the molecules it creates. While computational models can help predict chemical reactions, their current effectiveness is limited by a lack of reference data and the difficulty of accurat...

Strategic Innovation Trends in Small and Medium Industry Clusters for Enhancing Regional Tourism Competitiveness: A Bibliometric Analysis

Objective This bibliometric study evaluates the evolution of strategic innovation research within Small and Medium Industry (SMI) clusters to inform strategies for enhancing regional tourism competitiveness and long-term economic sustainability. Rather than merely synthesizing li...

Charge Storage and Dark Photocatalysis in Multivariate Ti‐Based Metal‐Organic Frameworks

ABSTRACT “Dark photocatalysis” decouples electron storage from photoconversion, offering a promising route to buffer solar intermittency, however requiring precise control of light‐matter interactions. Metal–organic frameworks (MOFs) provide a platform to tailor these interaction...

TIP-INN: A thermodynamics-informed machine learning framework for the mechanical behavior of rocks

Abstract Modeling the mechanical deformation of geological materials across relevant thermodynamic conditions and dynamic processes remains a fundamental challenge in Earth sciences. Conventional rheological models rely on isolated disciplinary approaches and hard-coded iterative...

Role of desolvation on biomolecular liquid–liquid phase separation

Abstract Biomolecular condensates play essential roles in cellular organization and are implicated in diverse pathological processes. Their formation is driven by liquid-liquid phase separation (LLPS), a process that requires coordinated multistep desolvation of biomolecular chai...

Temperature Dependence of Broadband Seismometer Sensitivity

ABSTRACT Broadband seismometers are widely used in global observation networks deployed for geophysics research. Recently, the calibration of their sensitivity has become an important factor for ensuring observation accuracy. One of the limiting factors of calibration uncertainty...