Research works

RGU-AVS: Residual-Driven Gaussian Uncertainty for Pool-Based Active View Selection in 3D Gaussian Splatting

Pool-based active view selection seeks to identify an informative subset of training images from a pre-acquired image pool, thereby reducing redundant observations of 3D Gaussian Splatting (3DGS). Existing methods mainly estimate candidate-view utility from predictive uncertainty...

Optimization of coal blending in thermal power plants using G ray‐ T aguchi method: An operations management perspective

Abstract Coal quality variability significantly affects the efficiency, operating cost, and environmental performance of coal‐fired thermal power plants. This study aims to optimize coal blending by integrating the Taguchi Design of Experiments (DOE) with Gray Relational Analysis...

Comparative virtual screening of African natural products against sickle haemoglobin: the β-chain hydrophobic acceptor pocket outperforms the Valβ6 surface for lateral-contact inhibition

Sickle cell disease arises from the Gluβ6→Valβ6 substitution in haemoglobin, which drives polymerisation through a lateral contact where Valβ6 inserts into a hydrophobic acceptor pocket on an adjacent β-chain. We compared two non-covalent inhibition strategies – capping Valβ6 and...

Beyond Risk Scores: Current and Emerging Strategies for Cardiotoxicity Risk Prediction in Cardio-Oncology

Background: Cardiotoxicity remains a major limitation of contemporary cancer therapies, affecting morbidity and long-term outcomes among cancer survivors. Early identification of patients at increased cardiovascular risk is essential to guide surveillance and preventive strategie...

Understanding Indigenous Economies Through Pre‐Figuration and Stabilisation to Advance Lifeways

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Calibration-Aware Patient-Level Prediction of Source-Defined MSIMUT Status in Colorectal Cancer from Whole-Slide Histopathology Images Using Foundation-Model Embeddings

Background/Objectives: Microsatellite instability (MSI) is clinically important in colorectal cancer, but definitive assessment requires molecular or immunohistochemical testing. This study developed a leakage-safe, calibration-aware patient-level framework for predicting a sourc...

A Science-Based Proposal for the Identification Threshold of Organic Impurities in Drug–Linker Intermediates Used to Produce Antibody–Drug Conjugates

Abstract The identification threshold for organic impurities in drug–linker (D–L) intermediates used to manufacture antibody–drug conjugates (ADCs) remains undefined in the current regulatory landscape. Building on our previously established 1.0% w/w qualification threshold, we p...

Air jet erosion behaviour of high-velocity air–fuel-sprayed WC-10Co-4Cr coatings reinforced with 2 wt-% La 2 O 3 on SS410 steel

The present investigation aimed to evaluate the influence of 2 wt-% La 2 O 3 addition on the microstructural characteristics, mechanical properties, and air jet erosion behaviour of high-velocity air–fuel-sprayed WC-10Co-4Cr coatings deposited on SS410 stainless steel. Cross-sect...

Nicotine Administration Robustly Enhances Fentanyl-Induced Dopamine Transmission Within the Dorsal Lateral Striatum

Opioid use disorder (OUD) is a prevalent public health concern in the United States. ∼70% of all drug overdose deaths are attributable to fentanyl, demonstrating a need to identify risk factors underlying the escalation of fentanyl use. Nicotine use is a risk factor associated wi...

De‐Escalation or Dose Redistribution? Interpreting the “Safe Omission” of Postoperative Neck Irradiation in pN0 Oral Cavity Cancer

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Phage-ICE tandems facilitate bacterial adaptation and antimicrobial resistance spread

Phages and integrative and conjugative elements (ICEs) drive bacterial evolution, but how their interplay shapes bacterial adaptation and antimicrobial resistance (AMR) dissemination remains unclear. Here, we characterize phage-ICE tandems formed by site-specific accretion of pha...

Consistent associations of BMI with ovarian response and pregnancy loss risk across PCOS, DOR, and tubal factor infertility: a complete-case mediation analysis of 8,923 IVF cycles

To investigate whether body mass index (BMI) affects in vitro fertilization (IVF) outcomes through consistent pathways across different infertility etiologies. A retrospective cohort study with mediation analysis. A reproductive medicine center in China. Of 11,524 eligible women...

Orbiting towards myopathy: new paradigms of muscle atrophy in spaceflight

Abstract Protracted exposure to microgravity during spaceflight imposes stress on the human body which disrupts physiological homeostasis. Skeletal muscles are among the most severely affected, and they are characterized by rapid muscle atrophy. Although basal autophagy maintains...

Examining Peer Bullying, Empathy, and Social Anxiety in Gifted and Typically Developing Students

This present study aims to examined differences in peer bullying, empathy, and social anxiety between gifted and typically developing students. A correlational survey design was employed within a quantitative research framework. The sample consisted of 161 children and 406 adoles...

Carbonic anhydrase VIII regulates IP3R1-dependent Ca 2+ signaling to coordinate insulin secretion and hepatic glucose production

Intracellular Ca 2+ signaling is essential for glucose-induced insulin secretion (GIIS) and hepatic glucose production (HGP), yet how Ca 2+ dynamics are coordinated across organs remains unclear. Carbonic anhydrase VIII (CA8), an endogenous inhibitor of inositol 1,4,5-trisphospha...

Transcriptomic and Proteomic Insights into Low Red Light: Far-Red Light Ratios Induced Internode Elongation in Cucumber Seedlings

The ratio of red to far-red (FR) light (the R/FR ratio) is a core signal regulating shade-induced internode elongation in plants, but the underlying mechanism in cucumber remains not fully elucidated. Therefore, in the present study, cucumber (Cucumis sativus L. ‘Zhongnong No. 26...

Irreversible electroporation for liver metastases not amenable to conventional treatments, an experience with technical challenges, clinical outcomes, and complications

Irreversible electroporation (IRE) is a non-thermal ablation technique for perivascular liver tumors unsuitable for conventional thermal ablation due to heat-sink effects. This prospective, single-center, single-arm study (2020–2025) evaluated IRE in 14 patients with 16 anatomica...

Effects of Dietary Allicin Supplementation on Laying Performance, Egg Quality, Serum Lipid Indices, and Gut Microbiota Composition in Kangle Chickens

Allicin was supplemented into the diet of Kangle chickens, a native Chinese chicken breed, and its effects on laying performance, egg quality, serum lipid indices, and gut microbiota were evaluated. A total of 144 hens at 30 weeks of age with similar body weights were randomly as...

Novel Compounds as TREM2 Agonists for Treating Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Nasu-Hakola Disease, and Stroke

Abstract Provided herein are novel compounds as TREM2 agonists, pharmaceutical compositions, use of such compounds in treating Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Nasu-Hakola disease and stroke, and processes for prepa...

Twin Prime Progress and Unproven Conjecture: Maynard's Sieve and Flawed Proof — E8 Intelligence Research

FINDING: Twin prime conjecture remains unproven; recent progress via Maynard's sieve methods and a flawed arXiv attempt claiming proof via sieve-of-Eratosthenes density arguments. MATH: Twin prime pair: \(p_x + 2 = p_y\). Maynard's theorem (2013): \(\liminf_{n\to\infty} (p_{n+k}...