Research works

Strain and Shear Wave Elastography in Thyroid Nodules: Tissue Stiffness as a Complementary Risk Marker for Differentiating Benign, Indeterminate, and Malignant Cytology

ABSTRACT Objective To evaluate the diagnostic performance of shear wave elastography (SWE) and strain elastography (SE) as complementary techniques to conventional B‐mode ultrasound for differentiating benign, indeterminate, and malignant thyroid nodules. Methods This prospective...

A Cogenetic Proof of the Poincaré Conjecture

This release presents a process-first Cogenetic proof of the Poincaré theorem. The manuscript begins with the independently derived Cogenetic non-collapse relation and its reciprocal magnitude-resolution ledger, then contextualises that invariant in a closed connected three-manif...

Stability-Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Fosinopril Sodium and Hydrochlorothiazide in Tablet Dosage Form.

ABSTRACT:A simple, specific, accurate, reliable, and stability-indicating reverse-phase high-performance liquidchromatographic (RP-HPLC) technique was developed and validated for simultaneous quantitation ofFosinopril Sodium and Hydrochlorothiazide in bulk drugs as well as their...

Identification and Characterization of an Electric Vehicle’s Operational Regimes Using Sensor Data

The increasing adoption of electric vehicles (EVs) has led to the generation of large-scale multi-domain datasets containing information on battery, thermal, charging, and driving behavior under real-world operating conditions. These datasets provide valuable insights into vehicl...

Condition-Specific LC Retention Time Prediction: Feature-Selected QSRR Versus Pretrained Graph Isomorphism Network Transfer Learning

Condition-specific liquid chromatographic retention time prediction remains challenging because retention depends on both molecular structure and experimental conditions. This study compared feature-selected quantitative structure–retention relationship (FS-QSRR) models with pret...

Impact of Using Flame-Retardant Electrolyte Additives in Li-Ion Batteries: A Comprehensive Evaluation of Ethoxy (Pentafluoro) Cyclotriphosphazene (PFPN)

Li-ion batteries (LIBs) are seeing increasingly widespread adoption across consumer electronics, electric vehicles, and grid-scale energy storage systems, yet their susceptibility to thermal runaway remains a concern. This study evaluates ethoxy (pentafluoro) cyclotriphosphazene...

Carbonyl stress promotes ferroptotic susceptibility through lipid metabolic remodeling in renal tubular epithelial cells

Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease worldwide and is characterized by progressive tubular injury, oxidative stress, and metabolic dysregulation. Carbonyl stress, driven by the accumulation of reactive dicarbonyl metabolites such as methylgly...

The genetic architecture of the CSF-contacting nucleus in mice and the screening of its key target via CSF pathway for mediating neuropathic pain

The cerebrospinal fluid (CSF)-contacting nucleus has been well characterized in rats and macaques but not yet precisely defined in mice. This study aims to provide a comprehensive description of the location, adjacent structures, cell morphology, spatial imaging, and genetic arch...

Exploring the impact of human development, education and R&D expenditures on nation brand competitiveness: evidence from cross-country panel data

Purpose This study investigates the impact of education and research and development (R&D) expenditures on nation brand value (NBV), while also considering the roles of government effectiveness (GE) and human development. This study aims to provide insights into how investmen...

Electrospun Chitosan/Collagen Fibers Incorporating PLGA and Hydroxyapatite Nanoparticles for In-Vitro 3T3 Fibroblast Migration

The development of 3D scaffolds that enable the reliable evaluation of cell migration remains a critical challenge in tissue engineering and wound-healing-related research. In this work, 3D scaffolds based on Chitosan/Collagen/Poly(lactic-co-glycolic acid) (PLGA)/Hydroxyapatite (...

Coping with premenstrual symptoms among women with irregular menstrual cycles: a qualitative study from Turkey

This study was conducted to examine how women with irregular menstrual cycles experience premenstrual symptoms, the methods they use to cope with these symptoms, and how this process is reflected in daily life. The study was designed using a phenomenological design, one of the qu...

Influence of Composting on the Agronomic Development of Cherry Tomatoes (Solanum lycopersicum var. cerasiforme): A Systematic Review

Agriculture plays a key role in global food production, whereas organic waste management remains an important environmental challenge. Organic residue-derived compost represents a sustainable strategy for nutrient recycling, soil fertility improvement, and reduced reliance on syn...

Bovines, buffers and barriers: A social scientific perspective on rewilding in the Kavango‐Zambezi Transfrontier Conservation Area

Abstract Rewilding is an increasingly popular nature conservation strategy globally. Originally, the strategy was formulated around the three C's of Carnivores, Cores and Corridors, which captured the ecological aim of rewilding to restore trophic interactions across large connec...

Capsaicin and diclofenac coloaded nanoemulsion gel optimized by quality by design approach of for the treatment of rheumatoid arthritis

Aims Rheumatoid arthritis (RA) is a chronic inflammatory disorder associated with progressive joint damage and pain. The present study aimed to develop and optimize a capsaicin – diclofenac-loaded nanoemulgel incorporating clove and olive oil for enhanced topical delivery and the...

FORMULATION AND EVALUATION OF MICRO SPONGE-LOADED HERBAL SOAP OF NYCTANTHES ARBOR-TRISTIS FLOWERS AND CHRYSANTHEMUM INDICUM LEAVES

The study aimed to formulate and evaluate a Micro Sponges-Loaded Herbal Soap containing leaf extracts of Nyctanthes arbor-tristis and Chrysanthemum indicum, both known for antimicrobial, anti-inflammatory, and antioxidant activity. The goal was to enhance therapeutic efficacy and...

Indigenous enFnCas9 and TnpB-Based CRISPR Technology: Translational Applications in India

AbstractCRISPR-based genome-editing technologies are progressing rapidly, outperforming conventionalCRISPR-Cas9 methods in medicinal and biotechnological applications. With unique structural andtranslational advantages, transposon-associated TnpB-based OMEGA systems and engineere...

Internal ElectricField-Induced “Proton Bridge”Mechanism in Photo-Self-Fenton Coupled PMS Systems: A TheoreticalStudy Based on Nonmetal Surface-Engineered Carbon Nitride

Abstract Constructing a photoself-Fenton (PSF) coupled peroxymonosulfate (PSF–PMS) system, which exploits the cross-activation between PMS and in situ generated H2O2 to boost reactive oxygen species flux, can overcome the kinetic bottlenecks of single advanced oxidation processes...

Firmness Variation in Tomato Fruit: Driving Factors, Signaling Regulation, and Genetic Basis

Fruit firmness is a pivotal agronomic and commercial trait that determines the storability, transport tolerance and edible quality of tomato (Solanum lycopersicum L.). Fruit softening severely restricts postharvest performance and economic benefits of tomato products worldwide. T...

Explicit Upper and Lower Bounds for D(x) and the Error Term of Order O(x^ε)

This paper studies the summatory divisor counting function D(x)=sum_{n≤x}τ(n). We derive its average‑value formula and establish explicit upper and lower bounds for D(x). The error term is governed by the maximum divisor count and satisfies the bound O(x^ε) for arbitrarily small...

Microbial Community Remodeling Mediates Soil Nutrient Enhancement and Fruit Quality Improvement Under Intercropping with Vicia sativa L.

This study investigated whether legume cover crops, particularly Vicia sativa L., improve soil fertility and fruit quality via microbial community remodeling, and whether this practice outperforms natural grass management in pear orchards. Five treatments were established: clean...