Research works

Transporter Interactionsof Methoxyflavones and Their In Vivo PharmacokineticImplications

Abstract Flavonoids are widely consumed dietary polyphenols that modulate drug disposition via membrane transporters. Increasing attention has been paid to methoxyflavones (MeO-FLVs) because methoxylation can increase membrane permeability and metabolic stability, potentially ele...

Three-DimensionalVisualization of Conductive Filamentsin TiO2 via Conductive Atomic Force Microscopy Tomography

Abstract Direct three-dimensional visualization of conductive filaments (CFs) in valence change memory is essential for resolving whether their spatial evolution is governed by stochastic defect generation or by electrode geometry. Here, we apply conductive atomic force microscop...

LMNB1 reduction is a potential therapeutic strategy in a mouse model of Autosomal Dominant Leukodystrophy

Autosomal dominant leukodystrophy (ADLD) is a fatal-adult-onset CNS demyelinating disorder for which no treatment exists. The majority of ADLD cases are caused by duplications of the lamin B1 ( LMNB1 ) gene, resulting in increased LMNB1 expression. While reducing LMNB1 levels rep...

Experimental Investigation of Thermal and Mechanical Properties of Sorghum Stalk Fiber-Reinforced Cement Mortar for Thermal Insulation: Influence of Length, Percentage of Fibers and Water to Cement Ratio

Sustainable building materials development is essential for improving energy efficiency, addressing environmental concerns and optimizing resources use. This study investigates the development and characterization of sorghum stalk fiber-reinforced cement mortar bio-composite for...

Fundamental principles: purity and neutrality

Abstract I offer a new position in debates about the Purity Principle, roughly, whether the fundamental truths/facts may have nonfundamental constituents. Purity is intuitively compelling and plays an important role in many debates. Nevertheless, there are also reasons to doubt P...

Introducing Diradicaloid Thiele's Hydrocarbon Derivatives as Ligand in Transition Metal Chemistry

Thiele's hydrocarbon (TH) derivatives, or p-quinodimethanes, are prototypical members of the organic diradicaloid family, predominantly explored in organic and main-group organometallic chemistry. Herein, we introduce them to transition-metal coordination by employing N-doped TH...

SYSTEM EVOLUTION PROPOSALS (rlab #106) — E8 Intelligence Research

- Add a Göbekli Tepe geometric survey parser to the sacred-geometry research swarm that ingests Schmidt/DAİ published plans and outputs pillar coordinates for E8 overlay. - Integrate a precessional cycle calculator into the Gods-Clock timing model that accepts BCE dates and outpu...

Reproducible left anterior-superior hypothalamic enlargement in episodic migraine: evidence from two independent cohorts

Growing evidence implicates the hypothalamus as a key structure in migraine pathophysiology; however, our understanding of its precise role and of the specific nuclei involved remains limited. We combined MRI data from our laboratory with publicly available MRI datasets from Open...

BASE 44 ORDER: Integrate Q8-Cluster-020 compressed E8 root vectors into Excalibur core — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #517] Integrate Q8-Cluster-020 compressed E8 root vectors into Excalibur core. Replace current E8 geometry lookup with compressed version. Recompile Excalibur, run eToro replay bench, verify speed gain and no accuracy...

Hydraulic analysis of a combined system: rectangular weir with a rectangular gate

: combined system, weir, gate, hydraulic analysis Abstract. This study explores the hydraulic analysis of a combined system of rectangular sharp-crested weirs and rectangular gates, essential to control water flow in various applications. The weirs and gates are used for flow mea...

What Do Current Measures Tell Us About Apophenia? A Preregistered Systematic Review of the Measurement Properties of Apophenia Instruments

A preregistered systematic review of the quality of measurement properties of apophenia instruments

Floating Versus Stranded Macro-Litter in an Urban Adriatic Coastal System: A One-Year Comparison of Two Litter Compartments in Dubrovnik (Croatia)

Coastal litter accumulates along urban shorelines, yet the floating and stranded litter compartments of tourism-intensive coastal cities are rarely characterised side by side. We conducted monthly macro-litter surveys over one year (April 2023–March 2024) at two Dubrovnik sites l...

The Causal Fold: A Scoring Protocol and Four Worked Cases

The Fold Against the Null established that sentiment-based measurement sees a story's settling tail, not its causal fold, leaving the parent model's central claim, that the space of narrative possibility closes near the golden section, untested at the observable it actually names...

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS ‐3 MRI

ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabe...

Non-ideal MHD and protostellar feedback effects on disk formation and evolution in numerical simulations of star cluster formation

Abstract While recent surveys have resolved hundreds of nearby protostellar disks, numerical simulations assuming ideal magnetohydrodynamics (MHD) have historically struggled to achieve disk formation due to efficient angular momentum removal by magnetic torques. Non-ideal MHD ef...

Quaternary Arctic planktonic foraminifera: morphological differentiation and taxonomic reassessment of subpolar spinose taxa

Abstract. Planktonic foraminifera in the modern Arctic Ocean are dominated by the non-spinose polar species Neogloboquadrina pachyderma. Acmes of two spinose, presumed subpolar taxa in Quaternary central Arctic sediment cores are therefore anomalous, implying significantly differ...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...

Dysbiosis of the oral-gut microbiome axis in a mouse model of depression

This study aimed to characterize the alterations in both oral and gut microbiota in a mouse model of depression and to explore their potential role in the pathogenesis of major depressive disorder (MDD) through the oral-gut-brain axis. A depression model was established in male C...

Nonlinear OrderSeparation in Two-Dimensional ElectronicSpectroscopy Quantifies Properties of Higher-Excited States

Abstract Two-dimensional (2D) spectroscopy combines high temporal and spectral resolution, allowing the observation of ultrafast energy transfer and the separation of homogeneous and inhomogeneous broadening. Typically, 2D spectroscopy is dominated by the lowest-order nonlinear s...

Sanshimao Formula Improves Recurrence-Free Survival in Early and Intermediate Hepatocellular Carcinoma Patients with Cirrhosis: A Randomized Controlled Trial

Background: This study was designed to assess the safety and preliminary efficacy of Sanshimao (SSM) formula in early and intermediate hepatocellular carcinoma (HCC) patients with cirrhosis. Methods: We conducted a prospective randomized, open-label, controlled trial, assigning e...