Research works

Timing of corticosteroid-sparing therapies in non-infectious uveitis: a population-based cohort study from Denmark

Abstract Background Non-infectious uveitis (NIU) is a group of potentially vision-threatening diseases where timely management is critical, yet data on the timing and sequencing of therapeutic interventions remain limited. Here, we evaluated real-world patterns and delays in init...

Cost-effectiveness of lenacapavir versus tenofovir disoproxil fumarate plus emtricitabine for pre-exposure prophylaxis to prevent HIV-1 transmission in gay, bisexual, and other men who have sex with men in Spain

Background Lenacapavir (LEN), a twice-yearly subcutaneous capsid inhibitor, has demonstrated superior efficacy over daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) in clinical trials. No European cost-effectiveness analyses...

The impact of blue ocean strategy’s ERRC grid on community engagement in higher education at Puntland state university in Somalia

The study assesses the extent to which Eliminate-Reduce-Raise-Create (ERRC) dimensions in the blue ocean framework associate with community engagement at Puntland State University (PSU) in Somalia. Specifically, it evaluates the effectiveness of the ERRC grid in strengthening uni...

EVALUATING THE IMPACT OF SOCIOECONOMIC AND HEALTH FACTORS ON QUALITY OF LIFE AMONG MINERS

Mining labourers contribute greatly to the economic development of mineral districts but lead a poor quality of life because of hazardous working conditions, low remuneration, and limited access to social well-being. The socio-economic and health problems of mining laborers are a...

Applications of First and Second Order Differential Equations in Science and Engineering

Differential equations form the mathematical backbone of nearly every quantitative discipline, providing the language through which change is modelled, predicted, and controlled. This paper presents a systematic study of first order and second order ordinary differential equation...

Health information seeking in the digital age: the association of social network and eHealth literacy in a state college

Purpose Social networking platforms have become a major source of health information among young adults, influencing how they access, evaluate and utilize health-related content. As digital health information becomes increasingly available, understanding the relationship between...

LPR-1-Mediated targeted intranasal delivery of lentinan-loaded polymeric nanocarriers for GBM therapy via modulation of apoptotic signalling

Aim To develop and evaluate a lactoferrin (Lf)-functionalized polyethylene glycol (PEG)-grafted chitosan (CS) nanocarriers (NCs) for low-density lipoprotein receptor-related protein-1 (LRP1)-mediated intranasal delivery of lentinan (LNT) to enhance brain targeting and anti-gliobl...

Multimodal profiling of HER2/neu-specific TCR-T cells reveals clonotype-dependent activation programs underlying differential cytotoxic efficacy

Abstract Adoptive T cell therapy targeting tumor-associated antigens offers a promising avenue for cancer immunotherapy, yet the mechanisms underlying functional heterogeneity among T cell receptors recognizing the same antigen remain poorly understood. Here, we comprehensively p...

The World Hammered Flat: Crowd Psychology, Conceptual Compression, and the Political Life of Simplified Meaning

Modern societies circulate vast quantities of information while depending on selection, representation, and compression to make complex realities communicable and actionable. Scientific findings are condensed into headlines; religious traditions are represented through identity m...

Tracking an Archetype: The Child Motif in Dreams and its Transformation in the Process of Psychotherapy

Abstract This study examines the occurrence of the child motif in dream series from psychoanalytic therapies in 38 cases using the grounded theory method. According to C. G. Jung's analytical psychology, archetypal symbols with universal forms emerge during the transformation pro...

More Than Fluid: AI-Derived Pleural Effusion Volume as a Marker of Cardiovascular Congestion in Transcatheter Aortic Valve Implantation

Background/Objectives: Pleural effusions are frequently encountered on pre-procedural computed tomography (CT) scans in patients undergoing transcatheter aortic valve implantation (TAVI). While often regarded as a marker of congestion and advanced cardiovascular disease, their cl...

High‐Detectivity InGaAs/GaAsP Superlattice PIN Photodetector with a Thin Absorber on GaAs substrate for 1100 nm Applications

ABSTRACT III‐V materials exhibit superior optoelectronic properties compared to conventional semiconductors, making them ideal for short‐wavelength infrared (SWIR) photodetectors. These devices are in demand for applications such as telecommunications, LiDAR, and biomedical engin...

Heat, Health and Holidays: Reported Heat Related Adjustments to Australian Tourist Behaviour

ABSTRACT Extreme heat is one of the fastest growing threats to human health, already causing tens of thousands of deaths annually and projected to affect hundreds of millions more people under continued warming. Australians are highly mobile and live in one of the most heat‐expos...

Liquid–liquid phase separation in a minimal explicit-solvent lattice model mimicking protein solutions

Biomolecular condensates play an essential role in cellular processes, and recent studies have focused on understanding their assembly and rational design principles. In this work, we have employed an explicit-solvent minimal statistical mechanical model based on the lattice-gas...

The impact of work-family policies on employee performance in the tourism industry

Purpose This study aims to explore the influence of work-family policies (WFP) existence and accessibility on employee performance within the tourism industry, emphasizing the mediating roles of specific WFP measures and the moderating impact of demanding work. Design/methodology...

Facility 190 DPR Form

State of California Department of Parks and Recreation primary record for Building 190 at Edwards AFB.

A Design-Technology Co-Optimization Framework Based on Process-Parameter Sensitivity Analysis

This paper proposes a design-technology co-optimization (DTCO) framework applicable to advanced technology nodes, which accelerates the process optimization exploration for such nodes. Developing automatic parameter extraction algorithms tailored for the BSIM-CMG model, along wit...

Surface Topography Improvement of Micro-Milled Inconel 718 Slots Through Abrasive Deburring: Comparison Between Polishing and Sanding

Burr formation remains a major challenge in micro milling due to reduced tool dimensions and size-effect phenomena, particularly when machining difficult-to-cut materials such as Inconel 718. This study compares the effectiveness of two abrasive deburring processes, polishing and...

Postbiotic mechanisms of long-term fermented soybean foods in host immunometabolic regulation: a critical appraisal of evidence, contradictions, and precision nutrition perspectives

Traditionally made long-term fermented soybean (LTFS) foods, including doenjang, miso, ganjang, and douchi, are produced through months to years of fermentation under high-salinity conditions (12-20% NaCl), generating convergent postbiotic profiles comprising free amino acids, is...

Can Artificial Intelligence Possess Meaning Without the Pressure to Survive? A Relational Account of Meaning, Grounding, Normativity, and the Limits of Large Language Models

Meaning is routinely conflated with information, representation, linguistic competence, or behavioral success. This Perspective develops a relational account in which meaning is the directional causal value that a difference acquires relative to a system's organization, goals, an...