Research works

Comparing Traditional Motor Speech Practice to Contextualized Speech Practice in Preschoolers With Childhood Apraxia of Speech

Purpose: The aim of this study was to compare retention of real-word targets across practice conditions (contextualized vs. motor-only) within a modified integral stimulation treatment for preschoolers with childhood apraxia of speech (CAS). Method: A single-subject experimental...

Claudin-like molecule in earthworms

Claudins belongs to a family of transmembrane proteins that are the most important components of the tight junctions. We present new claudin-like molecule of earthworm Eisenia andrei.

Autophagy induction mitigates FUS aggregate formation and early synaptic dysfunction at the NMJ in a FUS-ALS model

Mutations in Fused in Sarcoma (FUS), a RNA binding protein, cause Amyotrophic Lateral Sclerosis (ALS). ALS is an aggressive neurodegenerative disease resulting in motor neuron degeneration. Defects in synaptic integrity precede neuronal loss in ALS, but the mechanisms responsible...

Navigating regulatory scenarios for accelerating drug repurposing in rare diseases: a multi-stakeholder perspective on the challenges and opportunities

<title>Abstract</title> Background: The lack of treatments for patients with a rare disease calls for innovative approaches in drug development. A potential solution to accelerate therapy development is to find new therapeutic uses for existing drugs, i.e. drug repurposing. One w...

HydrogenBonding Networks Formed by Hydroxyl-FunctionalizedN-Heterocyclic Carbenes on Ag(111)

Abstract N-Heterocyclic carbenes (NHCs) have emerged as robust alternatives to thiols for metal-surface functionalization, offering strong σ-donor character, high thermal stability, and tunable molecular design. Despite advances in NHC surface engineering, the formation of ordere...

ARport: an augmented reality system for markerless image-guided port placement in robotic surgery

Abstract Purpose Precise port placement is a critical step in robot-assisted surgery, where port configuration influences both visual access to the operative field and instrument maneuverability. To bridge the gap between preoperative planning and intraoperative execution, we pre...

Starch granules are instructive scaffolds for synergistic reinforcement and dissipation in hydrogel composites

A fundamental challenge in soft material design is the competition between rigidity and dynamicity, as stiffening mechanisms typically suppress energy dissipation. Here, we demonstrate that starch granules serve as instructive scaffolds that overcome this constraint, enabling the...

Upward single-nozzle sprays: Droplet count, size, and velocity under flash pressures with directional conditional filtering

This study investigates the influence of pressure variation on droplet characteristics (count, size) and dynamics (velocity) in upward atomised full-cone sprays. The challenges of understanding the fundamental droplet behaviour in spray-flash desalination systems further imposes...

Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study

Abstract Background Sepsis is a major public health challenge, and reliable biomarkers are essential for distinguishing sepsis from other conditions. Neutrophil Gelatinase-Associated Lipocalin (Neutrophil gelatinase-associated lipocalin (NGAL)) has shown promise as a diagnostic m...

eDNA metabarcoding provides scalable and continuous biodiversity monitoring across the tree of life

Abstract Environmental DNA (eDNA) metabarcoding has the potential to substantially expand our knowledge of global biodiversity beyond that provided by conventional approaches. However, the degree to which eDNA data provides real ecological insight, rather than primarily reflectin...

Anterior cingulate cortex projections to the amygdala in primates: topographic and layer-specific organization underlying emotion and mood regulation

Abstract Emotion and mood regulation critically depends on interactions between the anterior cingulate cortex (ACC) and the amygdala. However, the detailed architecture of ACC projections to their major targets, the basal (BA) and accessory (AcBA) basal nuclei of the amygdala, re...

Analysis of 3GM High Accuracy Accelerometer data collected during JUICE lunar earth gravity assist

Abstract. The JUpiter ICy moons Explorer (JUICE) mission, launched in April 2023 by the European Space Agency (ESA), is designed to investigate Jupiter and its largest icy moons, Ganymede, Callisto, and Europa, with a focus on assessing their potential habitability and investigat...

An argument for parsimony in differentiable hydrologic models

Abstract. Differentiable hydrologic models that use machine learning to infer parameters for process-based models show promise for both prediction and inference. However, these models are often developed with time-varying parameters, despite evidence that such flexibility can und...

The nonlinear payoff of innovativeness under globalization: Environmental innovation, legitimacy, and customer loyalty

How does firm innovativeness translate into customer loyalty under globalization, when customer evaluations are nonlinear and shaped by legitimacy asymmetries? Prior research largely assumes linear innovation payoffs, overlooking how customers in globally competitive and institut...

Constraint satisfaction programming for the no-three-in-line problem

Using a constraint satisfaction formulation with rotational symmetry reduction, we exhibit configurations of 2 n points on the n × n grid for every 2 ≤ n ≤ 60 with no three collinear. These computations resolved every previously open case through n = 60 . We describe the formulat...

Bounded gaps and perfect power gaps in sequences of consecutive primes

Abstract We study whether several consecutive prime gaps can all be relatively large at the same time, or is it possible that all are squares or perfect powers, or perhaps none of them are squares? A few related results and problems are also presented.

Structural distortions and ferroelectricity in antiperovskite oxides with tetrel elements

Antiperovskites share the same structure as perovskites, but allow completely different chemistries and nominal charge states of anions to be stabilized. This gives rise to many interesting phenomena, including septet superconductivity and topological crystalline insulating phase...

Embedded injustice under the developmental state: Taiwan's reflexive governance on just transition

Taiwan has incorporated just transition into net zero governance, but implementation proceeds through institutions shaped by developmental state industrialization. This study examines how labor and environmental movements contributed to legal development and how unresolved legaci...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Retired doctors as users of patient-facing electronic health records: a mixed-methods survey in the UK and Spain

<title>Abstract</title> Background Online patient access to electronic records is expanding internationally but remains contested. Although clinicians’ concerns are well documented, less is known about how doctors’ views change when they themselves become patients. Retired doctor...