Research works

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

Abstract Background Myeloid cells orchestrate vascular inflammation through transcriptional programs that regulate their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, understanding of the transcriptional r...

How to Train Your Chatbot: Information‐Theoretic Foundations of Diagnostic Questioning in Inborn Errors of Immunity

BACKGROUND: Navigating the more than 550 inborn errors of immunity (IEI) requires efficient diagnostic reasoning. Information theory suggests questions should be prioritized by their capacity to reduce diagnostic uncertainty (entropy); yet whether experts or large language models...

Validation of a handheld smartphone markerless method for quantifying thoracolumbar flexion–extension range of motion in horses at trot

Abstract Background Back pain and poor performance in horses are difficult to assess objectively and thoracolumbar flexion‐extension range of motion (FE ROM ) is not reliably evaluated by subjective observation alone. A handheld, smartphone‐based markerless computer vision system...

LATTICE: A Governance-First Architecture for Authorized Autonomous AI Operations

Deploying autonomous AI agents in high-consequence operational environments requires organizational authorization, yet few frameworks provide end-to-end, testable governance mechanisms suitable for such authorization decisions. This paper introduces LATTICE (Layered Agentic Triad...

LATTICE: a governance-first architecture for authorized autonomous AI operations

Deploying autonomous AI agents in high-consequence operational environments requires organizational authorization, yet few frameworks provide end-to-end, testable governance mechanisms suitable for such authorization decisions. This paper introduces LATTICE (Layered Agentic Triad...

Intelligent Business Document Processing Using AI- and NLP-Based Techniques: A Systematic Literature Review

<title>Abstract</title> This literature review examines the emerging integration of artificial intelligence (AI) and natural language processing (NLP) in intelligent business document processing. The primary objective of this study is to identify intelligent platforms capable of...

Plastic polymer classification with shortwave infrared reflectance: Opportunities and limitations for remote sensing of marine debris

Marine plastic debris or litter poses urgent environmental, economic, and human health challenges, yet tools for polymer-specific detection with reflectance measurements remain limited. To advance optical classification capabilities, the newly curated and comprehensive MArine Deb...

Constitutive, endogenous, fluorescent membrane reporters for dynamic cell cycle analysis in Bacillus subtilis

ABSTRACT Bacteria increase in biomass and divide, but determining precisely when cell division completes is technically challenging. To aid time-lapse imaging and cell-cycle tracking, we set out to identify a protein in Bacillus subtilis that, when fused with a fluorophore, would...

Twenty years of inhaler therapy: A nationwide drug utilization study

AIMS: This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and p...

Estimating the Contribution of Traction Sanding to Observed PM10 Concentrations Using Mass Balance Arguments

<title>Abstract</title> PM ₁₀ concentrations in many countries in Europe are above or close to the limit values set out by the European commission for 2030. This includes both the daily mean and annual mean limit values of 45 µg/m ³ and 20 µg/m ³...

Unleash $Q$! cohomology, localization, and interpolation in Parisi-Sourlas supersymmetry

Parisi—Sourlas supersymmetric models are known to undergo dimensional reduction; that is, their physics is captured by models in two fewer dimensions. In this work, we revisit dimensional reduction, providing new arguments and reformulating existing proofs in terms of the cohomol...

Generalizing a family of scattered quadrinomials in $$\mathbb {F}_{q^{2t}}[X]$$

Abstract In recent years, several efforts have focused on identifying new families of scattered polynomials. Currently, only three families in $$\mathbb {F}_{q^n}[X]$$ are known to exist for infinitely many values of n and q : (i) pseudoregulus-type monomials, (ii) Lunardon–Polve...

Gene function predicts divergence across molecular levels

Abstract Genes can evolve through changes at their DNA, RNA, or protein levels. However, because these changes are measured using distinct and often incomparable metrics, their relative contributions to genic evolution remain unclear. Here, we address this challenge by developing...

Friends with drugs: The role of social networks in the opioid epidemic

The current opioid epidemic is the worst drug epidemic the U.S. has ever faced. We examine the role of social connections in its spatial spread. Having many friendship links to counties with high opioid exposure positively correlates with overdose death rates. To address identifi...

Management of a Fully Deployed Coronary Stent Migrated to the Left Main Artery

Migration of a coronary stent is an uncommon but potentially dangerous event during percutaneous coronary intervention (PCI), and it is even rarer once the stent has been fully deployed. We describe a 39-year-old man presenting with non-ST elevation myocardial infarction (NSTEMI)...

Induced Superfluid Cosmology: A Unified Framework for Emergent Gravity, Matter, and Dark Energy — Research Report (Standardization Edition, August 2026)

191-page research report + complete reproducibility package. This edition supersedes the February 2026 (V7) line; the legacy history is preserved in the repository tag legacy-v7-2026-02. What is new in this version 1. The origin of mass, rebuilt from Layer 0. Bogomolny principle...

Groundwater hysteresis increasingly decouples flowing network length from streamflow as snow shifts to rain

Abstract. Flowing stream networks expand and contract in response to dynamic groundwater levels. Field studies generally associate greater flowing network length (L) with higher streamflow (Q), but this neglects potential hysteresis caused by nonequilibrium groundwater flow after...

Influence of sex and time on cardiac remodeling induced by vitamin d supplementation

Abstract Background Vitamin D (VitD) exerts diverse biological effects, including on cardiac function, with a biphasic dose–response profile. The growing use of high-dose supplementation has raised concerns, as excessive VitD, even without hypercalcemia. However, the timing of th...

Mass Spectrometry-BasedProfiling of PersonalizedImmunopeptidomes in Thai Renal Cell Carcinoma

Abstract This study profiles the personalized immunopeptidomes of 13 Thai patients with renal cell carcinoma (RCC), addressing a critical knowledge gap in Southeast Asian populations characterized by distinct HLA allele distributions. We combined whole-exome sequencing (WES)–base...

Fixed-Composition Shuffle Asymptotics in the Full-Support Gaussian Regime

Fixed-composition shuffle asymptotics in the full-support regime. We identify the Fisher parameter I_pi = v^T Sigma_pi^+ v, prove JSD(T_{n,k} || T_{n,k+1}) = I_pi/(8n) + O(n^-2), and derive the local privacy-curve expansion delta(t mu_n) = mu_n{phi(t) - t Phi(-t)} + O(n^-1), wher...