Research works

The emergence of (3+1)-dimensional expanding spacetime from complex Langevin simulations of the Lorentzian type IIB matrix model with deformations

Abstract The Lorentzian type IIB matrix model is a promising candidate for a nonperturbative formulation of superstring theory. In this model, the eigenvalue distribution of the N × N bosonic matrices Aμ (μ = 0, …, 9) represents an emergent spacetime, which is determined by the d...

Bone flap resorption after autologous cranioplasty for traumatic brain injury: a case–control study in Vietnam

<title>Abstract</title> Introduction Autologous bone is a commonly used material for cranioplasty following decompressive craniectomy; however, it is accompanied by the inherent risk of resorption. This study aimed to identify factors associated with bone flap resorption (BFR) in...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Identification of prognostic genes for hepatocellular carcinoma based on hepatocyte and ketone body metabolism using integrated bulk and single cell RNA sequencing

<title>Abstract</title> Background The precise role of ketone body (KB) metabolism and the underlying cellular mechanisms in hepatocellular carcinoma (HCC) remain unclear. This study aimed to identify and mechanistically explore KB metabolism-related prognostic genes in HCC. Meth...

A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization

Abstract Asymptomatic gut colonization increases the risk of clinical infection and transmission by the multidrug-resistant pathogen Acinetobacter baumannii . Ornithine utilization was shown to be critical for A. baumannii competition with the resident microbiota to persist in gu...

The Effect of Predilatation on Procedural Outcomes in Patients Undergoing Saphenous Vein Graft Percutaneous Coronary Intervention for Acute Coronary Syndrome

OBJECTIVE: Percutaneous coronary interventions (PCI) of saphenous vein grafts (SVG) are technically challenging due to friable plaques, high thrombus burden, and the risk of distal embolization. The impact of balloon predilatation on outcomes in patients presenting with acute cor...

Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection

The detection of unexpected sounds, or auditory deviance detection, is thought to be achieved by comparing prediction signals and sensory inputs in the auditory cortex. This process is markedly impaired in patients with schizophrenia. However, the local circuit properties underly...

Persistent Free Volume Governs (Anti)plasticization in Chitosan-Water Mixtures

Abstract Chitosan is a highly versatile and sustainable polymer with a broad range of potential biological and materials engineering applications. Despite its versatility, the native brittleness of chitosan limits its broader utilization. This limitation can be addressed by blend...

Discovering Structural,Electronic, and ExcitonicProperties of Bulk, Nanostructured, and Doped C3N4 in Diamond- and Graphitic-Like Phases

Abstract In this systematic density functional theory study, we compare a standard gradient-corrected functional (PBE) with a long-range hybrid functional (HSE06), with and without correction for the dispersion forces, relative to their ability to correctly reproduce structural a...

Exact Toda black holes of rank-2 Lie groups

A bstract We consider Einstein gravity coupled to two Maxwell fields and one dilatonic scalar, and construct spherically-symmetric and static black holes that are charged under both Maxwell fields in general D dimensions. We find that for suitable dilaton couplings, the equations...

The Forced Operational Ordering of Logic, Sets, Types, and Categories: The Foundations of Mathematics

Any mathematical construction requires four operations to be performed in a fixed structural order. The four operations are distinction, placement, identity, and composition. Logic formalizes distinction, sets formalize placement, types formalize identity, and categories formaliz...

Antibacterial properties of medicinal plant extracts against antibiotic resistant organisms isolated from an abattoir in Lagos state

<title>Abstract</title> The rise in the utilization of medicinal plants for treating antibiotic-resistant pathogens in abattoirs in the present era has made the application of numerous plants containing active compounds that possess antioxidant, anti-inflammatory and antibacteria...

Impact of α-substitution on the photodissociation dynamics of nitromethane: The CH3 and NO release channels

Photolysis of 1-nitropropane, 2-methyl-2-nitropropane, and (nitromethyl)benzene at 213 and 225 nm reveals distinct mechanistic features in CH3 and NO elimination channels. The CH3 fragments exhibit anisotropic, non-statistical translational energy distributions, consistent with b...

Structural Response of Thin-Web Beams to Various Web Opening Retrofit Techniques

A novel retrofitting method was tested to open steel girder webs. As no standard covers these procedures, this study examined the effect of mid-span apertures on AISC-designed narrow I-beams. Ten specimens with 1.8m length, 0.8m height, and 0.3m flange width were examined, with f...

Benchmarking MeSH-augmented embeddings for biomedical document similarity

<title>Abstract</title> <bold>Background</bold> : The extensive volume of biomedical scientific literature requires efficient methods for retrieving relevant documents based on semantic technologies and biomedical concepts. While embedding-based methods have shown improvements ov...

Psychological distress among acute coronary syndrome patients – a descriptive cross-sectional study in patients managed at an interventional cardiology unit in Sri Lanka

<title>Abstract</title> <bold>Background</bold> Mental health issues are a globally prevalent problem. Psychological distress is an emotional and behavioural response to a stressor and can even lead to mental health disease. It is also associated with cardiovascular disease inclu...

Probing Voltage Dependence Interaction of Cationic Peptides with Bacterial Porins at A Single-Molecule Level

Abstract This study examined how cationic α‑helical antimicrobial peptides such as protamine exchange between the aqueous phase and the transmembrane β‑barrel porin OmpF ( E. coli ) at the single‑molecule level. High‑resolution conductance recordings in planar lipid bilayers reve...

Transient Receptor Potential Channel Signaling in Hypertension: Mechanisms, Translation, and Therapeutic Targeting

Arterial hypertension (HT) is a major risk factor in the pathogenesis of cardiovascular diseases and has a high prevalence. The pathogenesis of primary HT, which accounts for the majority of HT cases, has not been fully elucidated; therefore, effective treatment targets remain an...

HEPE — Complete 16-State AI Governance Space with Lyapunov Values (Hardware-Enforced Policy Engine)

Full enumeration of all 16 binary configurations of the HEPE (Hardware-Enforced Policy Engine) governance state space s = (hw_isolated, tz_active, r5f_active, audit_active) ∈ {0,1}^4, with Lyapunov function values V(s), bypass possibility classification, attack surface analysis,...

Long-term follow-up results of topical imiquimod for high-grade cervical intraepithelial neoplasia in young women: an original research

<title>Abstract</title> Background As cervical excisional treatment is associated with adverse pregnancy outcomes, imiquimod has been explored in several studies—such as the TOPIC-3—as an alternative but without success. Therefore, we designed a study focusing on patients aged &l...