Research works

Construction of In Vitro-In Vivo Correlation (IVIVC) Degradation Evaluation Model of Absorbable PCL/β-TCP Alveolar Bone Repair Scaffold and Exploration of a Biosafety Evaluation Idea Based on “Homeostasis”

Abstract Traditional in vivo degradation assessments for resorbable medical devices face challenges due to extreme durations, high costs, and a lack of criteria for reaching tissue-response steady states. This study investigates a 3D-printed PCL/β-TCP bone grafting scaffold by de...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...

Agricultural Producer Adaptation to Climate Change in Saskatchewan, Canada: Size Matters—but Most Importantly Cash Flow

An ethnographic study employing 72 qualitative interviews with agricultural producers and associated water decision-makers concerning farm climate change adaptation in Saskatchewan, Canada concludes that farm size matters. Inductively we established a distinction of 2025 hectares...

RTGNet: A Dual-Branch Network Integrating Recurrent Texture and Temporal Dynamics from sEMG for Lower-Limb Joint Angle Prediction

Accurate continuous prediction of lower-limb joint angles from surface electromyography (sEMG) remains challenging because of the nonlinear, non-stationary, and subject-specific nature of sEMG signals, which can reduce robustness and lead to degraded prediction accuracy during hi...

Infrastructural solidarity and informal continuing education: social purpose and critical equity in rural Indonesian teacher learning

Participation in lifelong learning is increasingly expected across contemporary societies; institutional provision, however, routinely fails practitioners in under-resourced, geographically isolated, and non-Western contexts. This study investigates how early childhood teachers i...

Traversing Type-II singularities by leveraging PM’s inherent dynamic characteristics

This paper presents a precise path-tracking method for a parallel manipulator (PM) to navigate Type-II singularities by leveraging its dynamic characteristics, thereby eliminating the need for offline recalibration, redundancy, or added mass. The approach is based on new insights...

Experiences of insemination fraud: discovering and navigating unexpected and entangled connections

The increasing use of direct-to-consumer genetic testing revealed not only more, but also different types of insemination fraud worldwide, making research into the topic urgently needed. This study explores how donor-conceived people and parents experience insemination fraud and...

On the Impact of Non-Stationary Spectral Noise in Satellite Image Restoration: A Spatial-Spectral Attention Benchmark

Multispectral satellite imagery from sensors like Sentinel-2 is essential for global earth observation but suffers from complex, non-stationary noise that varies across spatial coordinates and spectral channels. Traditional deep learning architectures frequently process multispec...

BASE 44 ORDER: Implement embedding_hash partial index with 60° angle binning and TTL cache — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1074] Add partial index on breakthroughs(embedding_hash) WHERE h+k+i=0. Modify agent to compute (h,k,i) via 60° angle binning. Query index before LLM call; store/retrieve responses keyed by (h,k,i) with TTL. Schedule...

Self-Sustaining Quantum Information Engine Operating on Discrete Spacetime Voxels via Toroidal Geodesics and Interaction-Free Measurement

This paper proposes a theoretical model for a self-sustaining Quantum InformationEngine (QIE) operating on discrete, volumetric spacetime at the Planck scale (voxels). Bydirecting photons into toroidal spiral trajectories (toroidal geodesics) within a localizedKerr-metric curvatu...

Comparative Genomics Reveals Diversification and Chromosomal Organization of Putative Antimicrobial Peptide-Derived Sequences in Amphibious Mudskippers

Antimicrobial peptides (AMPs) and AMP-like fragments are important components of vertebrate innate immunity, but their genome-wide diversification in amphibious fishes remains unclear. Here, we performed integrated bioinformatics and comparative genomic analyses of three represen...

General Assessment of Indole Derivatives and Wnt Pathway as Potential Key Factors Against Various Diseases, with Particular Emphasis on Thyroid Tumors

Indoles are chemical compounds that naturally occur in Prokaryotes and Eukaryotes. For example, indole alkaloids mainly occur in plant families such as Nyssaceae, Rubiaceae, Apocynaceae, and Loganiaceae. The popularity of indoles has led to further research into their function an...

Toward Sustainable Water Treatment: Hydraulic Retention Time Effects on Natural and Chemical Coagulants in Continuous-Flow Helically Coiled Tube Flocculators

Access to safe drinking water remains a global challenge, particularly in decentralized and low-resource settings where conventional treatment technologies may be economically or operationally impractical. Combining low-energy hydraulic flocculation systems with biodegradable nat...

Advances in Cyclic Peptides Targeting G Protein‐Coupled Receptors

Peptide‐responsive G protein‐coupled receptors (GPCRs) often recognize endogenous peptide ligands through extended receptor interfaces, providing opportunities for peptide‐based ligands to engage receptor contacts that conventional small molecules struggle to access effectively....

Ekarach Chandon English Foundational Corpus Charter

Version 3.1 of the Ekarach Chandon English Foundational Corpus Charter provides a governance and version-control framework for the Ekarach Chandon Corpus. It separates provenance class, claim form, assertion status, authorship and contribution, stop and resume conditions, open-te...

Unraveling HBV Life Cycle by Fluorescent Microscopy Imaging

The hepatitis B virus (HBV) is a worldwide hepatotropic virus despite the availability of a highly effective vaccine. Currently, the most efficacious treatment against HBV infection is the use of interferon and nucleos(t)ide analogs, which effectively suppress viral replication b...

Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiophobia Among Patients with Coronary Heart Disease: A Cross-Sectional Study

Jingwen Qin, Jiamin Li, Yan Zhou, Ping Yu, Xin Wang, Xin Pan, Kaizheng Gong; Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiop

Litote & Hyperbole: Artistic Research Protocol (2008-2026)

First article of the Litote & Hyperbole trilogy. Establishes the ground of inquiry through documentation of the artistic protocol, corpus constitution, and longitudinal observation of transformations in the face and body over time. Approximately seventy video portraits have been...

Toward the Systematic Design and Study of Mixed Reality Serious Games in Higher Education: Design Recommendations and a Multi-Dimensional Methodological Framework

Mixed Reality (MR) serious games combine immersive technologies with game-based learning to support training, skill development, and decision-making across diverse disciplines in university education. Although previous research has demonstrated improvements in engagement, usabili...

Endoscopic Endonasal Removal of an Intranasal Mesiodens: Importance of Three-Dimensional Evaluation for Approach Selection

Although mesiodens is a frequently encountered supernumerary tooth, its complete migration into the nasal cavity is a rare clinical finding that can lead to various nasal symptoms. This report describes a case of an intranasal mesiodens that had fully migrated out of the maxillar...