Research works

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Abstract Disruptions in airway branching or alveolar differentiation during lung development can lead to severe respiratory deficiencies and neonatal death. The molecular mechanisms governing branching patterning and early alveolar formation remain elusive. Loss of Svep1 function...

The Service-Life Trajectory: A Label-Free Degradation Gauge, Its Competence Boundary, and the Drift a Frozen One-Byte Monitor Must Survive

The Service-Life Trajectory: A Label-Free Degradation Gauge, Its Competence Boundary, and the Drift a Frozen One-Byte Monitor Must Survive Randolph James Ferlic, M.D. and Kimberly Kate Ferlic — Fieldstone Analytics, LLC, Austin, TX, USA Preprint · Zenodo DOI: 10.5281/zenodo.23321...

Spheres of Dharma: a second endless golden cycle of the icosahedral solids, through the icosidodecahedron, the fullerene cage and the rhombic triacontahedron

We describe an exact, endlessly repeating nesting of six icosahedral solids (the Ritsudō cycle), each layer filled by a few repeated pieces. With the dodecahedron at edge 1: an icosahedron of edge 1/φ, an icosidodecahedron of edge φ/2 (around it 12 pentagonal pyramids and 20 twis...

Machine-Certified Lean 4 Formalization of the General Divisor Theorem: Exact Density Correction under Residue Conditioning

We present an exhaustive, machine-certified formalization of the General Divisor Theorem (GDT) in the Lean 4 interactive theorem prover. Developed originally as a discrete analytic framework by thinkthoughts (2026), the General Divisor Theorem provides exact density corrections f...

Covariant Q-Interaction Dynamics in Early-Universe Collective Regimes: An OFT–VGM Framework and Conditions for Gravitational Concentration

This paper presents Version 1.0 of a covariant Q-interaction framework for investigating collective field dynamics and the conditions that may precede gravitational concentration in the early Universe. Building on the original Q-Interaction manuscript developed on 9 January 2026...

The Chain of Karma: the icosahedron and the dodecahedron as endless shells of each other

We show that the regular icosahedron and the regular dodecahedron can each be filled exactly as a shell around the other, and that the two shells alternate without end. A dodecahedron of edge 1 is an icosahedron of edge 1/φ inside a shell of 12 pentagonal pyramids, 30 AXE and 20...

The work cost of answering in real time

Many devices must answer each request before the next one arrives, while remembering what came before. This paper determines how much work such a device must spend per episode, one complete run of the process, for every finite interactive quantum process whose outputs carry the s...

The price of keeping time

A device that runs a quantum operation which does not respect time translation needs its own clock. This paper asks what owning that clock costs. Gates. The clock is paid for in capital, in the energy range of the heat baths, and in an energy that comes back only as a lottery, ea...

The price of time order

A physical device acts in time: inputs arrive, outputs are released and can no longer be touched, some systems are kept, and some must come back. This paper shows that the optimal work rate of such a device, over many uses at vanishing error, is fixed by one quantity, the least e...

Only quantum channels save work by waiting

Faist, Berta and Brandão showed that n uses of a time-covariant quantum channel cost, to leading order, n times its thermodynamic capacity, when the device may collect all inputs before it releases any output. Many devices cannot wait: they must release each output before the nex...

Photon Absorption Remote Sensing Virtual Histopathology: A Preliminary Exploration of Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies

Background: Photon Absorption Remote Sensing (PARS) enables label-free imaging of subcellular morphology by observing absorption interactions. Coupled with deep-learning, PARS produces label-free virtual hematoxylin and eosin (H&E) images in unprocessed tissues. This study evalua...

Exponential advantage in continuous-variable quantum state learning

We consider the task of learning quantum states in bosonic continuous-variable (CV) systems. We present an experimentally feasible protocol that uses entangled measurements and reflected states to efficiently learn, up to sign, the characteristic function of CV quantum states, wi...

Characterizing graphs with high inducibility

For a positive integer $k$ and a graph $H$ on $k$ vertices, we are interested in the inducibility of $H$, denoted $\mathrm{ind}(H)$, which is defined as the maximum possible probability that choosing $k$ vertices uniformly at random from a large graph $G$, they induce a copy of $...

PUS7 pseudouridylation of 7SK orchestrates human somatic cell reprogramming into iPS cells

Abstract Reprogramming human somatic cells into induced pluripotent stem cells (iPS cells) provides huge potential for regenerative medicine but its molecular regulation remains incompletely understood. In this study, we identify PUS7 as an RNA modification checkpoint that promot...

Comparative Effectiveness of Phenobarbital vs Diazepam for Alcohol Withdrawal Syndrome

Importance Phenobarbital use for alcohol withdrawal syndrome is increasing, but its effectiveness and safety have largely been compared with lorazepam rather than against more pharmacokinetically similar long-acting, self-tapering benzodiazepines such as diazepam. Objective To em...

Monitoring Seismic Moment Release and Focal Mechanisms at Cape and FORGE EGS Sites, Utah

ABSTRACT Accurate estimation of seismic magnitudes and focal mechanisms is a key component of seismic monitoring in enhanced geothermal systems (EGS) for evaluating the state of stress in the subsurface, efficiency of geothermal activities, and induced seismicity hazard. We prese...

Introducing a New Dimension of Individual Differences in Existential Psychology: Development and Initial Validation of the Existential Reflection Scale

Measuring individual differences in existential psychology has traditionally been centred around two key themes: (a) the ways in which individuals seek or attain meaning and purpose in life and (b) the extent of their anxiety related to existence and mortality. We introduce a new...

Extensive glacier loss in the coterminous United States

Glaciers populate the mountain ranges of the western conterminous United States and despite their importance to alpine hydrology, their area and volume change have never been comprehensively evaluated. Our study shows that since the mid-twentieth century about one-quarter of the...

Geography in the World Part 4: Towards Latin American Dialogues

ABSTRACT This fourth instalment of Geography in the World (GitW) aims to deepen engagement with geographical knowledge produced outside the Anglophone core—specifically, in Latin America—while reflecting on the practical challenges involved in doing so. The themed intervention co...

Modulating Access: Contributions From Latin America to the Study of Mobility and Care in the Urban Periphery

ABSTRACT This article examines theoretical and methodological innovations from Latin America in the study of urban mobility, exploring the relationship between access and care as experienced by domestic workers living in mass social housing projects on the outskirts of Mexico Cit...