Research works

Microaneurysm segmentation in early diabetic retinopathy: a localized patch-based U-Net approach to overcome microscopic lesion oversight

Abstract Background Diabetic Retinopathy (DR) is a leading cause of vision impairment and a major long-term microvascular complication of diabetes. Early detection and prevention of diabetes-related complications through advanced imaging and software-assisted patient management r...

Kovac Spectral Horizon (KSH): Spectral Horizon of the Maxwell Operator on 2D and 3D Domains

The Kovac Spectral Horizon (KSH) is introduced as a global spectral invariant for the Maxwell operator on general 2D and 3D domains. This work presents a comprehensive experimental study based on 23 independent geometries, including symmetric and asymmetric regions, porous struct...

Impact on health outcomes of treating all eligible large B-cell lymphoma patients with axicabtagene ciloleucel in Portugal – A modeling approach

AIM: This study aimed to quantify the health benefits that can be achieved by treating axicabtagene-ciloleucel (axi-cel)-eligible large B-cell lymphoma patients with axi-cel instead of historical standard of care (hSoC) in Portugal. "Estimated Opportunity Lost" quantified the dif...

The Maintenance Floor on the Heavy-Tailed Branch

Abstract Classical proofs of dissipation lower bounds rest on spectral gaps or logarithmic Sobolev inequalities, and both tools are natively suited to light-tailed steady states. In multiplicative open systems whose tail index lies in the Pareto range the spectral gap disappears,...

Managing Informational Uncertainty in Traceability Systems: A Structural Entropy-Based Model for Complex Production Systems

The digital transformation of shrimp aquaculture in Ecuador has accelerated the adoption of traceability technologies to improve transparency, regulatory compliance, and supply chain coordination. However, persistent structural limitations—such as technological fragmentation, low...

Interpreter Use and Challenges in Primary Care

This survey study investigates use of interpreters and challenges experienced by physicians treating patients with limited English proficiency.

Dietary Adjuvanticity in the Modern Plant Exposome: Implications for Immune-Mediated Inflammatory Diseases

Immune-mediated inflammatory diseases (IMIDs) arise from interactions among genetic susceptibility, epithelial barrier function, microbiota, diet, and other environmental exposures. Modern diets influence mucosal immunity not only through fibre intake, food processing, and microb...

Adult support and its role in the association between childhood adversity and quality of life in a population-based study

Abstract Background Childhood adversities can have long-term impacts on quality of life (QoL), health, and well-being. We surveyed an adult population to assess the prevalence of three common adverse childhood experiences (ACEs): parental alcohol problems, parental mental illness...

MODEL ADOPTION #1031: REJECT — LEDGER BENCH: Apply filter: Session = NY_OPEN — improves win rate from 31.5% to 37.5% (+6. — E8 Intelligence Research

DECISION: REJECT ELEMENT: The NY_OPEN session filter is not compatible with E8 geometry timing. E8-node/Gods-Clock rhythm logic operates on fractal phase transitions that are session-agnostic. Forcing a fixed UTC window (13:00-16:00 UTC) introduces a calendar-based constraint tha...

State entrepreneurialism under economic transition: Bounded rationality in China’s high-speed rail new town governance

Drawing on 16 high-speed rail (HSR) new towns along the Beijing–Shanghai corridor, this paper develops a middle-range explanation of how state entrepreneurialism is practiced and differentiated under conditions of economic transition in China. While the notion of state entreprene...

Development of low-carbon biocomposite from rice husk waste fiber for thermal insulation in climate-adaptive buildings

The escalating impacts of climate change on indoor environments have intensified the need for climate-adaptive, low-carbon building materials that enhance thermal resilience and energy efficiency. Conventional insulation materials remain heavily dependent on non-renewable resourc...

Fractal Acoustic Emission Characteristics and Energy Evolution of High-Water-Resistance Concrete Backfill: Roles of Water-to-Cement Ratio and Fiber Volume Fraction

Fiber-reinforced high-water-resistance concrete backfill (FHWCB) is a rapid-setting cementitious backfill system used for underground support and backfilling, but its stability is strongly affected by mixture water content and fiber dispersion. This study investigated the fresh-s...

Stump-related embolism from a thrombosed carotid–subclavian bypass causing large vessel occlusion after thoracic endovascular aortic repair

Background: Kommerell diverticulum frequently requires thoracic endovascular aortic repair (TEVAR) with carotid–subclavian bypass (CSB). Although CSB is durable, delayed embolic stroke secondary to graft failure is rare. We report a rare case of large vessel occlusion caused by a...

Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing

C-fibre nociceptors display low-level spontaneous firing in the context of tissue injury. Microneurography studies have demonstrated that such low frequency firing can dynamically regulate the activity-dependent slowing (ADS) or temporal pain signal relay of C-fibre nociceptors,...

Fifteen minute consultation: managing children with HNF1B pathogenic variants

Hepatocyte nuclear factor 1 beta ( HNF1B ) related disease is associated with multisystem involvement, most commonly renal developmental disorders and diabetes alongside a spectrum of other clinical features. With the increasing availability of genomic testing, paediatricians acr...

Efficient Hot‐Carrier Injection in Gradient‐Nanogap Plasmonic Absorbers for Solar‐Driven CO 2 Reduction

ABSTRACT Efficient light harvesting for photocatalytic CO 2 reduction has attracted considerable attention, yet thin‐film plasmonic photocatalysts often rely on lithography‐based techniques that limit scalability and increase cost, complexity, and reproducibility issues. Here, we...

On Pell, Narayana and Padovan Languages and Their Generalizations

In this article, we study several languages associated with classical integer sequences such as the Pell, Narayana, and Padovan sequences, as well as various generalizations. Some of these languages arise naturally in the context of graph theory. We show that a subset of these la...

Analysis of seasonal and long-term population dynamics for modeling populations at low density: Experience with light traps

Monitoring and population forecast of major pest species are important tasks for pest management in both agriculture and forestry. In current study we suggest the models for both flight-initiation within a season and multisession population dynamics at low population densities of...

Effects of acupuncture on brain function in patients with depression

Background: Depression poses a major global health burden. Many patients exhibit treatment resistance or experience intolerable side effects with standard therapies. Acupuncture shows promise as an adjunctive therapy for depression, but its neurobiological mechanisms remain incom...

THE OBESITY PARADOX IN DIABETIC CORONARY ARTERY DISEASE: IS BODY MASS INDEX ALONE SUFFICIENT?

Dear Editor,I have read with great interest the recently published article entitled "The Obesity Paradox in the Coexistence of Diabetes and Coronary Artery Disease" by Aydoğan et al. (1). The authors demonstrated that obese individuals with diabetes mellitus had significantly low...