Research works

Decision Custody: Who Answers for a Decision After the Machine That Made It Is Gone

If someone challenges an AI-made decision three years from now, could your organisation still show how it was made? For most, the honest answer is no. Models are replaced within a year or two, suppliers change hands, reference data is overwritten — while the decision itself lives...

Holographic Information Ontological Framework • The Brain — Companion Paper: The Writing Discipline of Ontological Language

Holographic Information Ontological Framework: The Brain (HIOFtB) This is a four-paper series plus a short companion note. It is written for readers in neuroscience, consciousness studies, algebraic topology, and the philosophy of mind -- not as a finished theory, and not only fo...

More than Infrastructure: How Institutional Frameworks Shape Socioeconomic Value in Toll Roads

Abstract Toll road projects are employed in developing countries to deliver critical infrastructure, fostering socioeconomic development. However, these initiatives often face community opposition because of misalignment between perceived local needs and promised benefits. This s...

The Bridge Certificate Applied to the Joshi ATS Series: A Ledger Audit (DRAFT)

DRAFT / work in progress. This is a versioned working paper of an ongoing research programme; newer versions supersede older ones. No claim about the truth of the abc conjecture, the correctness of IUT, or the correctness of the ATS series is made. We audit Kirti Joshi's Arithmet...

Electroweak Coupling Constants and the Koide Relation

Dimensionless constants occupy a special place in fundamental physics because their numerical values do not depend on the choice of units. This paper investigates an idealized geometric construction linking the Koide relation for charged leptons to the gauge couplings of the elec...

The contagion effect: time-varying volatility spillovers between cryptocurrencies and commodities during systemic shocks

This study examines the dynamic volatility spillovers between 10 prominent cryptocurrencies and commodities (Brent oil, WTI, and gold), along with the US Dollar Index (USDX), to understand their roles as hedges and safe-haven assets in turbulent market conditions. We examine dail...

Ryugu and Bennu preserve primordial isotopic heterogeneity absent from the meteorite record

Ivuna-type (CI) carbonaceous chondrites are commonly used as proxies for the composition of the planet-forming disk because their chemical abundances resemble those of the solar photosphere. However, their isotopic uniformity may reflect pervasive alteration and isotopic averagin...

The association between pubertal timing and diurnal cortisol activity in middle adolescence

The pubertal development stage is associated with mental health. One explanation is that the pubertal stage is linked to changes in hypothalamic‒pituitary‒adrenal (HPA) axis activity. However, no study has investigated the prospective association between pubertal timing and HPA a...

Content and composition of inorganic X-ray amorphous materials in temperate climate soils determined by the Rietveld method

Inorganic X-ray amorphous materials (iXAMs) are reactive soil components, including nanocrystalline minerals and mineraloids, often overlooked by mineralogical analyses. We evaluated their abundance and composition in temperate climate soils (Cambisol, Podzol, Chernozem, and Stag...

ARTIFICIAL INTELLIGENCE AND MULTI-OMICS IN ETHNOPHARMACOLOGY: ADVANCING PRECISION DRUG DISCOVERY FROM TRADITIONAL MEDICINE

Ethnopharmacology has played a pivotal role in drug discovery by documenting traditional knowledge of medicinal plants and their therapeutic applications. Numerous clinically important drugs, including aspirin, artemisinin, quinine, and paclitaxel, originated from ethnopharmacolo...

E8-Windmill Temporal Jitter Attenuation in Quantum Signal Propagation — E8 Intelligence Research

By applying the 132-step windmill parity rotation to the phase-noise distribution of quantum oscillators, we derive a stable temporal lattice that mitigates decoherence. The $\phi$-scaled interval between E8 root vector transitions creates a non-resonant buffer, preventing cumula...

Null-Structural Vacuum, Atemporal Actuality, and Pre-Dimensional Applicability: A Scenario-Typed Framework for Testing a Null-Structural Sector

This paper develops a scenario-typed formal framework for distinguishing an applicability boundary from a denoting null-structural scenario. The target symbol V₀ is not assumed to denote uniformly: Scenario A treats V₀ as a denoting NullSector, B rejects denotation, C begins mini...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Equitable revenue allocation in DEA under a common set of weights: a unified optimization approach

Data Envelopment Analysis (DEA) can be used to allocate common revenue. This paper proposes a common revenue allocation approach based on a common set of weights (CSW). The proposed approach is governed by two principles: efficiency ratio (ER) invariance and common weight ratio (...

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

ABSTRACT The stimulator of interferon genes (STING) pathway represents a central component of innate anti‐tumor immunity; however, the efficacy of STING‐targeted therapies is frequently limited by tumor‐intrinsic resistance mechanisms. Here, we identify lactate‐driven lactylation...

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Allopurinol in Hyperuricemia Treatment

This study integrated network pharmacology and metabolomics to investigate the mechanism of allopurinol in treating hyperuricemia (HUA). Therapeutic targets were identified by screening drug and disease databases. A drug-target-disease network was constructed and validated by mol...

Planning of potential mangrowe planting and tourism areas in Pangandaran Regency, West Java, Indonesia

This study aims to identify and plan potential areas for mangrove ecosystem planting (rehabilitation/restoration) as well as to identify and design potential areas for the development of sustainable mangrove ecotourism in Pangandaran Regency, West Java. This study focuses on six...

E8 Phi-Vortex Lattice Tuning for Quantum Memory Crystals — E8 Intelligence Research

By nesting Fibonacci-scaled E8 root vectors at 132Hz and subharmonics, we discover stable quantum memory crystals capable of storing information via phi-vortex lattices. These structures encode data through persistent homological tangles of coherent states, leveraging the 240 roo...

Analyzing the impacts of land use and land cover (LULC) changes on wetland Dynamics in Aba Samuel reservoir and its surroundings, central Ethiopia

This study investigates the impacts of land use and land cover (LULC) changes on wetlands ecosystems in the Aba Samuel Reservoir area, Ethiopia, over 30 years from 1994 to 2024. Remote sensing (RS), geographic information systems (GIS), and cloud-based processing using Google Ear...

HEPES: A Unique Case of Conformational Multi-ZwitterionicPolymorphism

Abstract HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid) is a widely used buffering agent in biological and biomedical research. Here, we reveal an exceptional solid-form landscape for HEPES. In addition to the two previously known polymorphs, we discover and c...