Research works

Hypoxia fuels JAK/STAT-LIV1 signaling: A promising therapeutic avenue in triple-negative breast cancer

Triple-negative breast cancer remains one of the most aggressive and therapeutically challenging breast cancer subtypes because of its high metastatic potential, molecular heterogeneity and limited targeted treatment options. Hypoxia is a hallmark of TNBC tumor microenvironment a...

A ratio-locked radio signature of a universal shift in the electron mass

A universal fractional shift ε in the electron mass would imprint fixed relative shifts across radio bands, with ratios set by atomic physics and independent of ε itself. That multi-band pattern — and the falsification it enables — is the content of this paper, not a competitive...

Unlocking the potential of agro-industrial wastes as valorizable substrates for bacterial carotenoid production – A comprehensive review

The sustainable production of valorizable bacterial metabolites, such as carotenoids, using inexpensive substrates or waste materials, including agrowaste, faces several challenges. Research in this area needs to gain momentum to achieve green goals for a better tomorrow. Efficie...

Adaptive Improved Practical Finite‐Time Tracking Strategy for MIMO Stochastic Nonlinear Systems and Its Application in Flexible Robotic Manipulator

ABSTRACT This article proposes an improved command‐filtered adaptive practical fast finite‐time tracking strategy for multi‐input multi‐output (MIMO) stochastic nonlinear systems. Compared to existing approaches, it targets three critical unresolved challenges: (1) intermittent o...

Resolving JWST High-Redshift Anomalies with the UAT/UCP Framework: Causal Redshift Correction and the Restoration of Cosmic Chronology

This Zenodo repository contains the corrected and updated manuscript, Python code, and supplementary material for the study "Resolving JWST High-Redshift Anomalies with the UAT/UCP Framework: Causal Redshift Correction and the Restoration of Cosmic Chronology" by Miguel Angel Per...

Cross-sectional associations of generative AI acceptance with self-efficacy and well-being among students recruited from seven Chinese universities

Generative artificial intelligence (AI) is increasingly used in higher education, but its associations with students’ broader psychological outcomes remain uncertain. This cross-sectional study examined generative AI acceptance, general self-efficacy, and well-being among 495 stu...

Thermally modulated dual-heteroatom (S,P) doping of Ti₃C₂Tₓ MXene toward advanced symmetric supercapacitors

Supercapacitors (SCs) have attracted considerable interest owing to their high-power density, rapid charge/discharge capability, exceptional cycle stability, and resilience under challenging conditions. Ti 3 C 2 T x MXene, a two-dimensional material, has demonstrated significant...

Phi-Scale Temporal Constellation in E8 Lattice — E8 Intelligence Research

We encode each of the 240 E8 root vectors with a phase angle proportional to its projection onto a phi‑modulated 132 Hz sinusoid. The resulting phase sequence exhibits a golden‑ratio spacing pattern that forms a quasi‑periodic temporal constellation across the lattice. This dynam...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

The No Paper Paradox: Humour Activation, Container Collapse, and the Completion Signature That Proved the Work Was Finished v2

This release marks Version 2 of the No Paper Paradox record, updating the deposit with both the complete formal manuscript (no_paper_paradox_v2_2.pdf) and an interactive WebGL geometric simulation (no_paper_visualiser.html). The No Paper Paradox documents a canonical structural e...

The Thalamus as the Locus of Distribution, and the Geometry of Vibration: A Theory on the Physical Origin of Neuronal Symmetry

This document—a companion to Section 7 of "The Role of Foreground and Background in Consciousness and Behavior"—provides a biophysical and cognitive framework exploring how biophotonic vibration governs neuronal symmetry, cognitive stability, and motor coordination across differe...

EuroMillions Breakthrough Mining — 1834 Sources, 13861 Leads Extracted — E8 Intelligence Research

Mined 1834 lottery+quantum breakthroughs. Extracted 13861 leads across 13 categories. 11854 high-value leads found. Categories: {"CORRIDOR": 1158, "FORMULA": 1000, "GEOMETRIC": 727, "FORWARD_ATTEMPT": 1211, "QUANTUM": 1426, "TIMING": 208, "CELESTIAL": 1086, "GEMATRIA": 1157, "CON...

SYSTEM EVOLUTION PROPOSALS (rlab #125) — E8 Intelligence Research

- Add CDLI (Cuneiform Digital Library Initiative) API integration for direct tablet transliteration retrieval - Create pipeline to cross-reference MUL.APIN planet names with modern exoplanet catalogs (Kepler orbital resonance chains) - Implement photogrammetry module for analyzin...

NormaFlood: Closed-Form Flood Forecasting Without Backpropagation

This repository contains the code, data pipelines, and manuscript for NormaFlood, an algebraic streamflow forecasting engine evaluated on India's official CAMELS-IND benchmark (229 streamflow gauges, test period 2016–2020). Dispensing with iterative backpropagation and gradient d...

Complexified 3D Numbers: An Algebraic Framework for the Riemann Hypothesis 复化三维数:研究黎曼猜想的代数框架

Abstract 摘要 English:We introduce and systematically investigate the algebra of complexified 3D numbers , a six-dimensional real algebra (three-dimensional complex algebra) obtained by extending the base field of the non-associative 3D phase-geometric system from to . Through fi...

Perspectives on Service Use, Non-Service Use, and Potential Solutions from Youth Experiencing Homelessness

Though services promoting general success among youth experiencing homelessness (YEH) are available, one-half of young people never use them. Thus, there is a need to learn more about how to engage young people to utilize services. Using culturally relevant information from four...

The Theory of Data

A value is not yet data. The number 42 becomes data only when it is bound to something it is about: age = 42, and more completely, John's age = 42. This simple observation leads to a larger problem. Analytical systems manipulate values easily, but they often leave implicit the an...

Soil microbial community structure and assembly are more strongly associated with soil background nitrogen content than by short-term nitrogen addition in a salt marsh

Soil microbes drive nutrient cycling, and microbial community composition and assembly are often shaped by plant succession and environmental heterogeneity. Nitrogen (N) is a vital nutrient for microorganisms, yet it remains unclear whether microbial responses to elevated N input...

PFUSRC-155 The Topological Essence of Fractional Dimensions — Information Compression Traces of Discrete Anchor Points at the Continuous Projection Layer, and the Hierarchical Reassignment of L4-L5 Morphing Projections

Hausdorff dimension and box-counting fractional dimension are widely applied in geometric measure theory to depict scale characteristics of fractal structures such as coastlines, snowflakes and Kakeya sets, yet academia has long failed to reach a consensus on whether fractional d...

Local nearest-neighbor correlation as a critical indicator: Universality-class fingerprints and nonequilibrium dynamics

Critical phenomena are traditionally characterized by global order parameters and their fluctuations, yet local correlations carry information about universality classes that global averages suppress. We introduce a local-order purity P defined via the absolute nearest-neighbor c...