Research works

Renal outcomes of SGLT2 inhibitors in ADPKD: a narrative review from mechanistic rationale to clinical trials

Abstract Inhibitors of the sodium-glucose cotransporter-2 (SGLT2i) were initially created for managing diabetes mellitus but have suggested significant renoprotective advantages regardless of blood glucose levels. SGLT2-inhibitors have thus emerged as a crucial component in the t...

Coverage and factors associated with receipt of early newborn postnatal care components in Afghanistan: findings from the 2022–2023 multiple indicator cluster survey

BACKGROUND: Neonatal mortality remains high in low‑ and middle‑income countries, where early postnatal care (PNC) within 48 hours can avert many deaths. Yet neither the national coverage of newborn PNC nor the factors associated with its receipt have been assessed. OBJECTIVES: We...

Snake Swarm: A Heterogeneous Multi-Agent Architecture for Reliable LLM-Based Task Execution

Recent advances in large language models (LLMs) have not eliminated their tendency to produce errors on complex reasoning tasks. Existing mitigation strategies---scaling to larger models, majority voting, or post-hoc repair---each carry fundamental limitations in cost, reliabilit...

Effects of Seat-Integrated Low-Frequency Acoustic Vibration on Muscle Mechanical Properties and Electromyographic Responses During Real-World Driving

Prolonged driving is associated with musculoskeletal loading, muscle fatigue, and discomfort, which may adversely affect driver performance and well-being. This study investigated the effects of seat-integrated low-frequency acoustic vibration on muscle mechanical properties and...

The Effect of Root Canal Irrigation Solutions on Surface Roughness and Microhardness of Biodentine

Aim It was aimed to evaluate the effect of a continuous chelation protocol (HEBP/NaOCl) on the microhardness and roughness of Biodentine used for root perforation repair.Material and method Biodentine discs (N=76; 5 mm × 2 mm) were fabricated per manufacturer’s instructions and f...

Selenium-containing polycaprolactone 3D-printed scaffold for osteogenesis enhancement and bone healing

Bone fractures present significant surgical and healthcare challenges and require innovative bone regeneration strategies. Current research explores selenium (Se)-enhanced polycaprolactone (PCL) scaffolds for improved defect repair. Selenium, known for its antioxidant, anti-infla...

E8 Hyperbolic Entanglement Reservoir for Adaptive Quantum Networks — E8 Intelligence Research

The 240 E8 root vectors are first mapped through a phi‑modulated hyperbolic conformal transformation at the base 132 Hz, generating 1680 phase‑conjugate pairings that form a highly resonant, frequency‑multiplexed manifold. By embedding this manifold into a topological qubit latti...

The Coupled Portfolio: Relative Blame and the Anti-Markowitz Geometry of Oversight

Recurring oversight blind spots — an auditor who misses a specialist's error — are increasingly read as equilibria: where blame for a missed failure rises with how much a monitor could see, seeing less is a way to bear less. A companion model shows the blind spot survives across...

The Risks to Patients Associated with Using Artificial Intelligence Tools in Pharmacy Practice: A Scoping Review

Artificial intelligence (AI) tools are being used in pharmacy practice in a variety of ways, such as enhancing the safety and efficiency of dispensing, compounding medications and helping pharmacists identify drug–drug interactions. The further development and use of these innova...

Impact of highly intensive functional balance training in children with developmental coordination disorder

Abstract Children with Developmental Coordination Disorder (cDCD) face significant motor coordination challenges, impacting daily activities and participation. This study examined the effects of highly intensive, functional balance training across different levels of the Internat...

The Influence of Regional Subsidies to Innovation on Beneficiary Firms’ Financial Statements: A Comparison Between a Couple of Italian Regions

The paper aims to investigate whether regional innovation subsidies have a relevant effect for beneficiary firms, taking into account a couple of different regions in Italy, namely Lombardy and Sicily, characterized by different subsidy rules and local productive structures. The...

An inverse design method for electric machines based on conditional variational autoencoder

Electric machines play a key role in electromechanical energy conversion across modern industrial systems. Conventional design methodologies typically involve many repetitive tasks that exhibit low computational efficiency. To address this challenge, this paper proposes an invers...

Roles, Challenges, and Institutional Responses of Security Personnel in Ensuring Campus Safety at Tangub City Global College

Abstract. Campus safety is a fundamental concern in higher education institutions worldwide, yet the roles, experiences, and operational challenges of security personnel in government-funded Philippine higher education institutions remain underexplored. This qualitative descripti...

Genotypic features of antimicrobial resistance, virulence determinants, and clonal lineages of Enterococcus spp. reported in Brazil: a scoping review with marked regional asymmetry

Abstract Purpose Vancomycin-resistant Enterococcus faecium is listed in the 2024 WHO Bacterial Priority Pathogens List as a high-priority agent of hospital-acquired infections. Its persistence is supported by marked genomic plasticity across human, animal, food, and environmental...

From Grape to Wine: Targeted Profiling of Selected 34 Bioactive Phenolics in Negoska Variety, an Unexplored Indigenous Greek Grape Cultivar

Wine is a widely consumed beverage and important source of bioactive polyphenols, molecules with well-established health beneficial properties. The winemaking process produces byproducts, such as pomace, seeds and stems, which also comprise a valuable resource for sustainable val...

Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming

Osteoarthritis (OA) lacks approved disease-modifying therapies. Here, by integrating quantitative proteomics with reanalysis of public single-cell RNA sequencing data from human articular cartilage, we identify thymidine kinase 1 (TK1) as a pathogenic regulator linking inflammato...

Hydrophobic Eutectogels Reinforced by Zn2+-Coordinated Lignin Nanoparticles for Underwater Wearable Electronics

Abstract Wearable flexible sensors for underwater communication and biomotion monitoring are gaining attention. However, developing gel-based strain sensors with high toughness, anti-swelling performance, robust underwater adhesion, and long-term stability remains challenging. He...

Reverse Mechanism of Gravitational Time Dilation and Decisive Verification Using GPS

Whether the atomic transition spacing varies with gravitational potential is anuntested presupposition in general relativity. This assumption directly deter-mines the causal direction of gravitational time dilation: if the atomic transitionspacing is a universal constant, time fl...

Metal‐Based Combination Therapies in Cancer: Mechanistic Principles and Emerging Opportunities

Metal-based anticancer agents occupy a distinctive niche in cancer therapy owing to their exceptional coordination versatility, redox activity, and tunable photochemical properties, which enable simultaneous engagement of multiple cellular pathways. Despite the clinical success o...

Integrating Land Use Change and Vegetation Resilience to Assess Ecological Impacts of Expressway Construction: A Case Study of the Linghua Expressway

The rapid expansion of road construction has significantly contributed to economic development and regional connectivity. However, linear infrastructure such as roads, railways, and utility corridors has also introduced considerable ecological disruptions. Although increasing glo...