Research works

Computational modeling of motor-driven extension of microtubule bundles in axons reveals a biphasic effect of crosslinker density

In addition to actin assembly at the growth cone, neuronal axons elongate via interactions between microtubules, dynein motor proteins and cross-linking proteins. Dynein translocates microtubules toward the growth cone and exerts extensile forces for axonal outgrowth. During this...

SLC25A12 mitigates mitochondrial dysfunction in myoblast senescence, and alleviates cuproptosis-related changes under copper stress

Sarcopenia is an age-related muscle wasting condition that currently lacks specific diagnostic biomarkers and effective treatments. This study aimed to identify mitochondria-related biomarkers for sarcopenia via integrated multi-omics. Human transcriptomic datasets and machine le...

Acoustic–phonetic characterization of affect in spontaneous Finnish

Earlier studies of affect in spoken Finnish have largely been based on acted emotional expression, a relatively small number of speakers, and a narrow linguistic scope paired with predefined emotional categories. While previous studies have reported consistent findings related to...

Reduced Food Availability Amplifies Behavioral Depression and Impairs Locomotor Performance After Immune Challenge in Xenopus laevis

Mounting an immune response and locomotor activity are energetically costly processes that can generate trade-offs affecting energy allocation, muscle performance, and activity patterns. The balance between these demands can be modulated by factors such as food availability and e...

Temporal dynamics outweigh spatial gradients in shaping water quality across a regulated Afrotropical reservoir cascade

Abstract Water quality in regulated tropical reservoirs is shaped by the interplay of seasonal hydrology, spatial habitat heterogeneity, land use, and climate variability, yet the relative importance of these drivers remains poorly quantified in African river basins. We aimed to...

ARTICLE XI : THE 4-DIMENSIONAL COMBAT LOG AND THE EPISTEMOLOGICAL RUPTURE

Classical academia inherently isolates the domains of astrophysics, epidemiology, and computer science, resulting in a fragmented diagnosis of the modern era. This manuscript executes an absolute epistemological rupture, permanently unifying the 2017 interstellar incursion ('Oumu...

The Theology of Hope in Times of Economic Hardship: A Biblical and Contextual Response to Nigeria's Socio-Economic Crisis

Abstract Nigeria's contemporary socio-economic crisis, characterized by rising inflation, unemployment, poverty, food insecurity, and increasing social vulnerability, has created significant challenges for individuals, families, and communities. Beyond economic concerns, these re...

Missingness Has a Universe: A Typed and Compositional Foundation for Missing-Data Research

Version 1.1 is a vocabulary revision, content-preserving: aligned with The Theory of Data, Version 4.0 — a measure is the governed family; a member of a measure is a governed series; a series is a typed binding of datums over one anchor. Nothing is altered in substance.Modern mis...

Longitudinal Relation Between Childhood Maltreatment and Problematic Gaming in Early Adolescents: The Mediating Roles of Self-Control and Sex Differences

Childhood maltreatment has been linked to heightened risk for problematic gaming among adolescents, yet the self-regulatory processes underlying this association remain insufficiently understood. Drawing on the dual-mode model of self-control, the present three-wave longitudinal...

A latency-aware multispectral image processing framework for real-time band compression and spectral-spatial optimization

Real-time multispectral image processing requires a design criterion that is different from offline spectral modeling: the selected bands, features, and classifier must be evaluated by both recognition performance and end-to-end runtime. This paper presents a latency-aware framew...

Optimization and Tactical Deconfliction for Drone Search-and-Rescue in Low-Altitude Airspace: A Systematic Literature Review

Unmanned Aerial Vehicle (UAV) swarms are increasingly deployed in search and rescue (SAR) missions to rapidly locate survivors. However, deploying autonomous swarms in low-altitude airspace shared with crewed rescue aircraft poses significant algorithmic and safety challenges. Fo...

MicroRNA signatures of equine asthma phenotypes in serum and bronchoalveolar lavage fluid

Equine asthma (EA) is a highly prevalent, chronic, inflammatory disease of the lower airways ranging from mild-to-moderate to severe clinical presentations. Diagnosis currently relies on bronchoalveolar lavage fluid (BALF) cytology, an invasive method associated with interobserve...

The Defensive Misalignment Hypothesis - Can Behavior-Contingent Alignment Produce the Behaviors It Seeks to Prevent?

This conceptual paper introduces the Defensive Misalignment Hypothesis (DMH), a history-dependent account of how alignment procedures may alter the strategic incentives of sufficiently capable artificial agents. DMH proposes that some behaviors commonly classified as misalignment...

Influence of transboundary wildfire smoke on fine particulate matter concentrations at South Texas border schools

Exposure to air pollutants in indoor and outdoor school environments poses significant health risks to children due to their heightened vulnerability. Increasing wildfire frequency has intensified transboundary smoke transport, with border communities among the first to experienc...

Real-World Safety and Efficacy of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Retrospective Cohort Study of 38 049 Patients

BACKGROUND: Chronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adju...

Fatigue damage behavior and structural optimisation of asphalt concrete-reinforced subgrade in ballastless tracks under extreme climates

Abstract In cold regions, extreme cold and freeze–thaw cycles cause frost heave, layer separation, and fatigue cracks in high-speed railway ballastless tracks, posing a risk to the structure and safety. This study examines CRTS III tracks with full-scale fatigue tests at − 48 °C...

Effectiveness of Intra-Socket Application of Dexamethasone- and Hyaluronic Acid-Soaked Gelfoam in Mandibular Third Molar Surgery

Abstract Background Extraction of impacted mandibular third molars are commonly associated with postoperative pain, facial swelling, and trismus. Local intra-socket drug delivery provides targeted therapy with minimal systemic drug exposure. This study compared the efficacy of de...

Socio cultural determinants of dietary and health behaviours among women of reproductive age in rural India

A qualitative study was conducted to understand the sociocultural dynamics influencing the food security of women of reproductive age in Tantichira, a rural tribal village of Odisha, India—a representation of developing countries. Eastern societies worldwide were found to have fo...

Lycium barbarum glycopeptide attenuates ischaemic stroke by inhibiting inflammation via SIRT3-mediated NLRP3 deacetylation

Background Inflammatory processes play a critical role in ischaemic stroke. Acetylation of NLRP3 is a key step in amplifying neuroinflammation. (LbGP), a bioactive glycoprotein derived from Lycium barbarum, has anti-inflammatory potential, but its mechanisms in post-stroke neuroi...

Global Realism: Spacetime Vacuum as the Unique Physical Reality and Quantum Mechanics as Its Topological Dynamics

We propose a unified physical framework in which four-dimensional spacetime vacuum is the unique physical reality, and all quanta are its localized topological excitations. Matter particles correspond to stable knot-like configurations, while radiation quanta correspond to weak p...