Research works

FDA Approval Summary: Retifanlimab for the treatment of adult patients with metastatic or inoperable locally recurrent squamous cell carcinoma of the anal canal

Abstract On May 15, 2025, the Food and Drug Administration approved retifanlimab in combination with carboplatin and paclitaxel for treating unresectable or metastatic squamous cell carcinoma of the anal canal (SCAC), and as a single agent for second-line SCAC treatment. These ap...

Does organisational culture drive attitude and subjective norms towards energy-saving behaviour among SME employees: a theory of reasoned action perspective

Purpose This study aims to apply the Theory of Reasoned Action (TRA) to explain energy-saving behaviour among employees of small and medium enterprises (SMEs), in which attitudes and subjective norms shape behaviour. The author builds on this perspective by adding organisational...

Exploring non-linear influences of urban environment on urban vitality using multi-source geographic big data

Urban vitality (UV) is a crucial indicator of the prosperity, livability, and sustainability of cities, yet its complex and non-linear relationship with the urban environment (UE) remains underexplored. Therefore, taking Nanjing as the study area, this study integrated multi-sour...

Predictive value of C-reactive protein for progression from prehypertension to hypertension: a prospective cohort study based on the CHARLS database

Abstract Background The key to preventing and treating hypertension is predicting the progression of prehypertension and implementing preventive and control measures. Whether C-reactive protein (CRP) can predict the progression from prehypertension to hypertension remains to be c...

Effects of Ramadan fasting on glycemic control and lipid profile in type 2 diabetes mellitus: a systematic review and meta-analysis of clinical studies

BACKGROUND: Fasting is believed to confer metabolic health benefits; however, evidence regarding its effectiveness in patients with type 2 diabetes mellitus (T2DM) remains inconsistent. This study aimed to evaluate the effects of Ramadan fasting (RF) on the glycemic control, lipi...

Quantitative biochemical profiling of GCase activity and α-synuclein proteoforms in post-mortem human brains from GBA-related and idiopathic Parkinson’s disease

Variants in GBA1 , encoding lysosomal glucocerebrosidase (GCase), are risk factors for Parkinson’s disease (PD), which is characterized by α-synuclein (αSyn) accumulation and lysosomal dysfunction. Nonetheless, the relationship between αSyn accumulation and GCase deficiency remai...

Why is Gully Erosion Escalating in Itu and Uyo Local Government Areas, Akwa Ibom State, Nigeria? Local Reportage and Field Observations

Gully erosion has transitioned from a natural geomorphic process into a widespread environmental hazard in Itu Local Government Area, Akwa Ibom State. This study examines the drivers of escalating gully expansion through a synthesis of local reportage, field observations, and emp...

Biologically informed TCR representations improve in-distribution prediction but fail to generalize to unseen epitopes

Background. TCR specificity predictors work on epitopes seen in training and fail on unseen ones. One explanation holds that receptor representations ignore the organization created by V(D)J recombination. We tested it. Methods. From 121,467 deduplicated human TCRβ clonotypes in...

Linking physiological indicators and HSC70‑2 gene expression to acute thermal tolerance and stress thresholds in common carp ( Cyprinus Capio )

This study delineated acute thermal thresholds in common carp Cyprinus carpio (39.9 ± 5.27 g; 13.54 ± 0.67 cm) by integrating physiological (cortisol, hematology, serum biochemistry, opercular movement) and molecular (HSC70-2) responses to rapid temperature shifts. Fish were acut...

Hydropower Scheduling of Cascaded Reservoirs Using a Hybrid Gurobi–PSO Algorithm

Abstract Optimal operation of short-term power generation solutions for cascade hydropower stations is an important part of current reservoir operation and management. Existing population intelligence optimization algorithms exhibit limitations including susceptibility to the ini...

EuroMillions Breakthrough Mining — 1374 Sources, 9239 Leads Extracted — E8 Intelligence Research

Mined 1374 lottery+quantum breakthroughs. Extracted 9239 leads across 13 categories. 7332 high-value leads found. Categories: {"CORRIDOR": 750, "FORMULA": 602, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 781, "QUANTUM": 994, "TIMING": 179, "CELESTIAL": 690, "GEMATRIA": 735, "CONSTANT":...

Bounded Ownership-Transfer Ranks and Multilayer Strategy Certificates in Finite Shogi Legal-Move Systems

We study a finite-horizon reachability problem in finite state systems generated by the ordinary local movement, promotion, drop, and King-safety rules of shogi. A fixed non-king physical token is labelled by provenance, and the terminal event is its first ownership transfer to t...

Ultrasonographic Evaluation of Superior Cluneal Nerve Entrapment: Methodological Considerations. Comment on Iudicelli et al. The Role of Musculoskeletal Ultrasound in Detecting Superior Cluneal Nerve Entrapment: Biomechanical Insights in Chronic Low Back Pain—A Pilot Study. Diagnostics 2026, 16, 469

Superior cluneal nerve (SCN) entrapment is an underrecognized cause of chronic low back pain, and musculoskeletal ultrasound has recently gained attention as a potential diagnostic tool. In a recent pilot study, an indirect ultrasonographic triad consisting of thoracolumbar fasci...

EuroMillions Breakthrough Mining — 1398 Sources, 9503 Leads Extracted — E8 Intelligence Research

Mined 1398 lottery+quantum breakthroughs. Extracted 9503 leads across 13 categories. 7596 high-value leads found. Categories: {"CORRIDOR": 774, "FORMULA": 626, "GEOMETRIC": 677, "FORWARD_ATTEMPT": 805, "QUANTUM": 1018, "TIMING": 179, "CELESTIAL": 714, "GEMATRIA": 759, "CONSTANT":...

Reproducibility of Volumetric Analysis using Ultra-Low-Field Portable Magnetic Resonance Imaging

Brain volume change over time is an important imaging-based biomarker of disease. However, traditional MR scanners are associated with high direct and indirect costs both up front and over time, rendering them inaccessible to many around the world. Recently, ultra-low-field (64 m...

Collet-Sicard syndrome associated with probable intracranial vasculitic arteriopathy: a case report

Collet–Sicard syndrome is unilateral palsy of the glossopharyngeal, vagus, accessory, and hypoglossal nerves. It is most commonly caused by neoplastic, traumatic, or vascular lesions at the skull base. To our knowledge, its association with intracranial vasculitis has not been re...

Metagenomic Profiling of Diarrheagenic Escherichia coli Pathotypes Reveals Predominance of Diffusely Adherent and Enteroaggregative Subtypes and Mixed Signatures Among Under-Fives in Tanzania

Diarrheagenic Escherichia coli (DEC) is a leading enteric pathogen in children under five in sub-Saharan Africa, yet conventional targeted assays fail to capture mixed virulence signatures or provide quantitative context relative to E. coli carriage. We applied a virulence-aware...

Optimized and Aligned Anisotropic Monte Carlo Sampling Patterns

Abstract Path tracing uses Monte Carlo integration to solve the rendering equation by evaluating the integrand at random sampling points. The convergence rate of the error can be significantly improved by using correlated instead of random sampling, especially on smooth integrand...

Visual strategies in influencer marketing campaigns: The role of consistency

Abstract This research analyzes the role of visual features in influencer marketing campaigns, focusing on visual consistency within campaigns. Using 707 posts and 1,105 stories from 182 campaigns, we extract 47 visual and consistency features along four fundamental visual dimens...

Fisher Information Limits on Genetic Stability, Diversity, and Regulation

Abstract Life and evolution require precise yet imperfect transmission of genetic information across generations. Accurate transmission maintains the genetic blueprint for phenotypes that succeed in current conditions, while some transmission error is necessary to generate herita...