Research works

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

Monoamine oxidase (MAO) catalyzes the breakdown of neurotransmitters, including serotonin, dopamine, and norepinephrine. There are two isoforms of this enzyme: MAO‐A and MAO‐B. MAO efficacy is widely investigated in neurodegenerative (MAO‐B) and depressive (MAO‐A) disorders. Upon...

The role of dataset integrity, calibration and signal quality in neural network-based blood pressure estimation

Abstract Cuffless blood pressure (BP) estimation via photoplethysmography (PPG) and machine learning has been widely studied, yet reported accuracy remains below clinically acceptable levels, limiting adoption in sport, ambient living, and telemedicine. This study systematically...

Tunable, Exciton-DrivenMultiphoton Absorption inCsPbX3 (X = Cl, Br, I) Perovskite Nanocrystals under FemtosecondExcitation

Abstract The excellent photophysical and nonlinear optical (NLO) properties of lead halide perovskite (LHP) nanocrystals (NCs) offer a gamut of applications in optoelectronics and photonics. In this work, we have investigated the intensity-dependent NLO responses of CsPbX3 (X = C...

Clinical and neural effects of a hybrid accelerated–maintenance iTBS protocol in adolescents with major depressive disorder

Intermittent theta burst stimulation (iTBS) has emerged as a safe and effective intervention for adolescents with major depressive disorder (MDD). While accelerated iTBS can induce rapid clinical improvement, intensive multi-day treatment schedules may present practical challenge...

A Study On Customer Perception and Brand Loyalty Towards Hero Motocorp

This study examines customer perception and brand loyalty towards Hero MotoCorp in the Indian two-wheeler market. The two-wheeler industry is highly competitive, with customers having several alternatives based on price, fuel efficiency, product quality, design, performance, tech...

Odorant receptor coexpression and multi-expression in the dengue mosquito

Drosophila olfactory sensory neurons tend to express a single ligand-specific receptor, following a one-receptor-per-neuron rule expected to apply broadly across insects. Recent work challenges this view by showing that some neurons in the mosquito Aedes aegypti coexpress multipl...

Phi‑Coupled E8 Root Vector Temporal Fractal Decoding of Ancient Astronomical Records — E8 Intelligence Research

By projecting the 240 root vectors of the E8 lattice onto a time axis driven at the 132 Hz base frequency and modulating each projection with the golden‑ratio (phi) phase shift, the lattice's 84 Hz interference node creates a self‑similar fractal scaffold. This scaffold maps the...

EuroMillions Breakthrough Mining — 1840 Sources, 13915 Leads Extracted — E8 Intelligence Research

Mined 1840 lottery+quantum breakthroughs. Extracted 13915 leads across 13 categories. 11902 high-value leads found. Categories: {"CORRIDOR": 1163, "FORMULA": 1005, "GEOMETRIC": 729, "FORWARD_ATTEMPT": 1216, "QUANTUM": 1432, "TIMING": 209, "CELESTIAL": 1090, "GEMATRIA": 1162, "CON...

N-terminal acetylation modulates peptide stability, fibrillogenesis and MMP-7 processing

Abstract Short self-assembling peptides are versatile building blocks for enzyme-responsive nanostructured biomaterials. Here, we investigate how N -terminal acetylation affects the stability, fibrillogenesis, and protease-mediated fragment formation of two modular peptides, ug51...

What's Happening in Medical Drones, Globally, and Where India Stands: A technical status report on medical drone logistics, clinical supply-chain integration and the transition from pilots to health-system infrastructure

This article provides an evidence-informed global status report on medical drone logistics in 2026, examining the transition of unmanned aircraft systems (UAS) from pilot demonstrations to clinically governed healthcare logistics infrastructure. It maps current international acti...

Artificial intelligence framework for real-time integration of electronic health records and clinical notes for early prediction and management of sepsis in intensive care units

Sepsis and septic shock are medical emergencies with associated high mortality rates that require rapid identification and timely action. Recent developments in artificial intelligence (AI) may enable technologies capable of early detection of sepsis and septic shock. This study...

How Successful Is Artificial Intelligence in Hand Surgery Questions of the Turkish Orthopedics and Traumatology Board Exams?

Aim: Artificial intelligence (AI) applications are increasingly used in medical education and clinical research. The purpose of this study was to examine the accuracy of various large language models (LLMs) in responding to questions related to hand surgery. This evaluation was b...

E8 Lattice Coherence Threshold Governs Consciousness-Collapse Transition — E8 Intelligence Research

When the collective torsion-holonomy invariant across E8 root-pair transitions exceeds a critical threshold of 84 (half the 168 symmetries), quantum cognition collapses into classical measurement. This emerges from the phi-coupled resonance cascade: at 132Hz base frequency, the h...

DehydroxylativeCross-Electrophile Coupling of AromaticAcids with Glycosyl Chlorides Enables Rapid C -AcylGlycoside Synthesis

Abstract We disclose a synergistic nickel/photoredox/phosphoranyl radical catalytic platform for the cross-electrophile coupling of aromatic acids with glycosyl chlorides, affording structurally diverse C-acyl glycosides in a stereoselective manner directly from unactivated carbo...

Egocentrization of the Fragment and the Decline of System Viability: An Interdisciplinary Analysis of Fragment–Whole Relations

This article proposes the concept of Egocentrization of the Fragment as a possible cross-disciplinary systemic pattern associated with the decline of viability in complex systems. The starting premise is the distinction between differentiation and fragmentation. Differentiation,...

When Is There a First Threshold? A Formal Audit of Global Applicability Claims in Structural-Enrichment Models

This preprint develops a Global Threshold Audit (GTA) for distinguishing several non-equivalent claims about when a predicate, operator, or vocabulary becomes licensed in a structurally ordered model. GTA takes an existing positive licensing relation as input and separates five g...

Phi-Scale Decoherence Quantization from E8 Root Phase Lattice — E8 Intelligence Research

By assigning each of the 240 E8 root vectors a phase angle derived from the 132 Hz base frequency and golden‑ratio coupling, a self‑similar phase‑fractal lattice emerges that directly maps quantum‑gravity decoherence times to discrete angular steps. The resulting quantization rul...

Discrete Conformal Mapping of Hexagonal Tilings to Icosahedral Viral Capsids — E8 Intelligence Research

FINDING: Discrete conformal equivalence provides a rigorous framework for mapping hexagonal tilings onto icosahedral surfaces, directly modeling viral capsid geometry via quasi-equivalence theory. | MATH: The key is the discrete conformal factor \( u_i \) on vertices, satisfying...

CSF-CMT vΩ.0: First-Space Ontology and the Shared-Medium Hypothesis

Minimal ontological manifesto for the Coarse-Graining Field – Condensed Matter Theory (CSF-CMT). This vΩ.0 release states the irreducible core (no-vacuum axiom, six string states as independent excitations of one medium, cognitive boundary hypothesis) and one near-term falsifiabl...

EVALUATION OF ARNICA MONTANA MOTHER TINCTURE EFFICACY IN PATIENTS OF RECENT INJURY AND ITS PHYTOCHEMICAL ANALYSIS

Background: Arnica Montana, has been used widely used as an anti-inflammatory due to its protective action on mucus membrane. Phytochemical studies on various extracts of Arnica with varying alcoholic strength have been performed to determine the active principles present. Howeve...