Research works

Difelikefalin Treatment in Chronic Kidney Disease-Associated Pruritus: Modelling Infection-Related Hospitalisation Cost Offsets Using Trial and Real-World Data Across Seven European Countries

INTRODUCTION: We estimated cost offsets from treating moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) with difelikefalin, through reduced infection-related hospitalisations (IRHs). METHODS: Using Stockholm CREAtinine Measurements study data, IRH rates were...

Synergistic enhancement of strength and ductility in wire arc additive manufactured Mg-Gd-Y-Zr alloy via Ag addition

To overcome the strength-ductility trade-off and poor formability of high-RE magnesium alloys, Mg-13Gd-3Y-XAg-Zr (x = 0, 1, and 2 wt.%) thin walls were fabricated via wire arc additive manufacturing (WAAM), followed by subsequent solution treatment and peak-aging treatment (T6)....

An Enhanced Fault-Tolerant Scheme for Arm-Multiplexing Modular Multilevel Converters

The arm-multiplexing modular multilevel converter (AM-MMC) is a new compact MMC topology that is especially promising for offshore high-voltage direct current transmission systems. However, the reliable operation of AM-MMCs suffers from submodule (SM) faults. The fault-tolerant s...

UCI BioEYEs: A Graduate-Student-Led Model for Sustainable, Inclusive Science Outreach

Zebrafish are a powerful, accessible vertebrate model for teaching core biology concepts. BioEYES is a well-established K-12 outreach program that uses inquiry-based classroom investigations to leverage these strengths. However, its traditional model relies on dedicated personnel...

Reflectance confocal microscopy and pathological correlation of tumor microenvironment in adnexal cancers during balstilimab treatment

Adnexal carcinomas (AC) are rare, locally aggressive tumors with limited systemic treatment evidence and no validated immunotherapy biomarkers. Reflectance confocal microscopy (RCM) enables non-invasive, in vivo tumor microenvironment (TME) imaging at near-histologic resolution....

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of...

Aortic Dissection Mimicry Under Extracorporeal Membrane Oxygenation (ECMO) After Cardiac Arrest: A Case Report of Emergency Imaging Dilemmas

Background and Clinical Significance: Peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) substantially alters aortic flow dynamics, generating catastrophic false-positive pathology on standard imaging. We report a case of ECMO-induced artifacts mimicking a Sta...

Bidirectional Multi‐Channel Programmable Metasurface for High‐Security Wireless Information Steganography

ABSTRACT With inherent abilities of directly modulating digital information on reflection and transmission properties, programmable metasurfaces have been extensively explored in wireless communications. However, realizing multi‐channel metasurface‐based wireless communication th...

Decade-long persistence of CD19 CAR T cells in B cell lymphomas

Abstract Chimeric antigen receptor (CAR) T cell therapy induces durable remissions in lymphoid malignancies, yet the extent and biology of long-term CAR T cell persistence in B cell lymphoma remain unclear. Here we report the persistence and characteristics of 4-1BB-costimulated...

Traffic-Driven Spatial and Seasonal Variability of Rainwater Chemistry: Insights from Multivariate Analysis in Bucharest, Romania

Urban rainwater is an increasingly important alternative water resource, but its suitability for harvesting and reuse depends on a water quality that varies strongly with local emissions and season—a variability not previously characterised for Bucharest, the Romanian capital. Th...

Machine learning-assisted fixed-bed column adsorption of chlorpyrifos using sustainable biomass-derived activated carbon

Abstract Chlorpyrifos pollution in aquatic streams has become a serious environmental concern due to its high toxicity and adverse effects on ecosystems and human health. In this study, continuous fixed-bed column adsorption of chlorpyrifos was studied using activated carbon synt...

InflammatorySerum Olink Proteomics in Cancer-RelatedPain Treated with Opioids: A Pilot Cross-Sectional and LongitudinalStudy

Abstract Opioid analgesia shows substantial interindividual variability in cancer patients, yet the underlying serum inflammatory alterations remain poorly characterized. This study collected plasma samples from 44 cancer pain patients before and after opioid initiation, quantify...

Time-varying drivers of CO 2 emissions in China: a rolling window analysis (2000–2023)

This study examines the time-varying determinants of per capita CO2 emissions in China over 2000–2023, focusing on how macroeconomic, financial, and institutional factors evolve. Using annual data from the World Bank and governance indicators, a rolling window Ordinary Least Squa...

Unlocking the Potential of Sparingly Soluble LiNO 3 in Carbonate Electrolytes With Pyridine as a Carrier Cosolvent for 450 Wh Kg −1 High‐Voltage Lithium Metal Batteries

ABSTRACT LiNO 3 is a highly effective electrolyte additive for ether‐based lithium metal batteries, but its extremely poor solubility in carbonate electrolytes has long restricted its application in high‐voltage high‐energy‐density systems. In this study, we develop a pyridine ca...

A Home Between Environmental Changes and Climatic Anxiety

It is becoming harder to feel at home. As wildfires, floods, drought, and heat become recurrent rather than exceptional, and as everyday life fills with weather alerts, evacuation warnings, and preparedness drills, many people experience a particular kind of distress: the pain of...

Explicit task reasoning empowering robotic manipulation

Currently, robots still struggle to perform human-like explicit task reasoning. Most existing vision-language-action (VLA) approaches heavily rely on large-scale demonstration datasets and carefully designed models, which pose significant challenges for model interpretability, ge...

Elevated aerosol layers within the daytime mixed layer over ecologically sensitive areas of northwest China: diurnal variation, formation mechanisms and regional effects

Abstract. The cyclic processes of aerosol evolution have a profound impact on regional climate, water resources and ecosystems. However, studies on diurnal variations of aerosol vertical distribution in typical ecologically sensitive areas remain scarce due to limited availabilit...

Photocatalyzed RegioselectivityTrifluoromethylationand Sulfuration of Unactivated Alkenes with S -ArylTrifluoromethanesulfonothioates (TTSA)

Abstract Under photocatalytic conditions, a novel and highly reactive trifluoromethylthiolation reagent, S-aryl trifluoromethanesulfonothioate (TTSA), reacted with various unactivated alkenes to produce sulfurized and trifluoromethylated derivatives in high yields. Furthermore, a...

Rectal Surveillance for Carbapenem-Resistant Klebsiella pneumoniae: Prevalence and Clinical Relevance in a Multidisciplinary Tertiary-Care Hospital

Background/Objectives: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a high-priority healthcare-associated pathogen. This study aimed to estimate rectal CRKP carriage and characterize same-patient clinical-site CRKP detection. Methods: We conducted a single-center retrospe...

Core genome and whole genome multi-locus sequence typing of Cronobacter isolates

ABSTRACT Cronobacter species, especially C. sakazakii and C. malonaticus, are opportunistic pathogens that are linked to severe infections in infants with high case fatality rates. In this study, we investigated whole genome sequencing (WGS) analysis approaches, specifically 7-ge...