Research works

Use of machine learning to enhance detection of transient astronomical phenomena in historical observatory images

Transient, star-like point sources that appear and vanish over short timescales are described in astronomical images prior to launch of Sputnik. We have reported that transient numbers diminish significantly in Earth’s shadow (shadow deficit) and are more likely within (+/-) one...

pyMSscreen: an interactive interface for automated quality control and prescreening in mass spectrometry workflows

Reliable quality control of mass spectrometry data remains a major bottleneck in target, suspect and non-target screening workflows. In non-target analysis, thousands of features can be extracted through automated peak picking, many of which require manual verification to exclude...

Search for neutrino emission from blazar <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"> <a:mi>γ</a:mi> </a:math> -ray flares accounting for possible neutrino time delays

We report the results of the search for the high-energy neutrino emission associated with blazar flares, accounting for a possible lag of neutrinos with respect to the electromagnetic emission, either due to the slowness of the proton energy losses in <mml:math xmlns:mml="http://...

The efficacy and safety of monthly intravenous methylprednisolone pulse therapy in Taiwanese alopecia areata patients: A retrospective cohort study

Abstract Background: Intravenous methylprednisolone pulse (IVMP) therapy has been widely used for treating severe or recalcitrant alopecia areata (AA), but treatment protocols and efficacy vary. Objectives: This study aims to evaluate the efficacy of IVMP, identify predictive fac...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...

Clinical insights: an update on transmucosal absorption with a focus on dodecyl maltoside

INTRODUCTION: Nasal administration provides a favorable option for patients with a variety of disease conditions and their caregivers, including for acute treatment therapies in the community setting. This noninvasive route of administration allows for device portability and quic...

IoT System for Level Monitoring and Control with Point-to-Point LoRa Between Siemens S7-1200 PLCs

Industrial supervision can be expanded through the Internet of Things (IoT) without moving the control logic outside the PLC. This study evaluates a level-monitoring and control architecture using a point-to-point LoRa link between two Siemens S7-1200 PLCs; LoRaWAN is used solely...

Micro-CT radiomics reveals the microcalcification-surrounding tissue interface as the diagnostic epicenter of breast microcalcifications

In clinical breast imaging, microcalcifications (MCs) are routinely interpreted as small radiological signs, typically analyzed in clusters. They guide radiologists in assessing breast lesions and determining the likelihood of malignancy. Yet, increasing biological evidence indic...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

Prediction of DistalMutation Effects in Enzymes viaIntegration of Molecular Dynamics Descriptors and Zero-Shot Model

Abstract Identifying beneficial distal mutations remains a key challenge in enzyme engineering, as such residues can regulate activity through long-range dynamical coupling and allosteric communication. Although protein language models effectively capture sequence and evolutionar...

Emergence and Dissemination of NDM+OXA-48-like Co-Producing Klebsiella pneumoniae in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy

Background/Objectives: The epidemiology of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) in Europe is evolving towards an increasing contribution of metallo-β-lactamases (MBLs). In particular, co-production of New Delhi metallo-β-lactamase (NDM) and OXA-48-like carbapenemase...

Nones with religious identities: characteristics of those who select both religious and nonreligious identities

Survey research tends to classify individuals as either having a religious identity or having a nonreligious identity/no religious identity. This binary is a function of religious identity questions typically only allowing for a single response. In this study we used unique data...

Depleted uranium final disposal: why classification does not settle long-term safety for large inventories

Depleted uranium (DU) sits at the intersection of radioactive-waste management, resource policy and environmental radioactivity. Its initial specific activity is low, and it may be retained as a potential resource or managed within low-level, low-activity or material-management c...

Enhancement of UV Protection and Performance of Reactive-Dyed Cotton Fabrics via TiO2 Nanoparticle Pad–Dry–Cure Treatment

The development of multifunctional textiles with enhanced ultraviolet (UV) protection has attracted increasing attention due to the growing demand for protective and high-performance clothing. In this study, cotton fabrics dyed with reactive dyes at three dye concentrations (0.5%...

Suicide Prevention Training Experiences, Needs and Perceptions among Catholic Clergy in Nigeria

Our study draws attention to an important but underexplored resource for suicide prevention in low-and middle-income countries: faith leaders, who function as highly accessible community leaders.By examining Nigerian clergy's training experiences, capacity needs, and perspectives...

Entropy Production in a DC Plasma Diode with a Fireball on the Anode

One of the consequences of driving a plasma discharge away from the thermodynamic equilibrium is the appearance of one or more fireballs in front of the anode. The formation of this self-organized space charge structure marks the transformation of part of the thermal energy of th...

Air Quality Evidence in Road and Rail Transport Corridors: A Comparative Systematic Mapping Review

Aerosol emission and dispersion in transport corridors are central to urban air quality, human exposure assessment and transport planning. Although near-road air pollution has been widely studied, much less is known about analogous processes in rail-related environments, especial...

Centrifugal shaking-table test study on the dynamic responses of rock slope containing weak interlayer reinforced with prestressed composite structure

Abstract Background Rock slopes containing weak interlayers are susceptible to seismic-induced sliding failure along the interlayer planes. This study aims to investigate the dynamic response of prestressed composite structures reinforced rock slopes containing weak interlayers....

Toward Differentiated Biological Citizenship: Genetic Controversies and the Creation of Taiwan’s Collective Informed Consent Law for Indigenous Peoples

Since the 1990s, Taiwan has promoted genomics as part of its shift to a knowledge economy. However, controversies concerning Indigenous genetics and genomics extend into political, sociocultural, and historical dynamics. This has prompted a movement among Taiwan's Indigenous acti...

Odontocete Occurrence in Highly Trafficked European Straits: Insights from Static Acoustic Monitoring

Static Acoustic Monitoring (SAM) using C-PODs, deep C-PODs, and F-PODs was conducted as part of the STRAITS project (Strategic Infrastructure for improved animal Tracking in European Seas), funded under the EU’s Horizon research and innovation programme, to investigate odontocete...